Quantification of Human T-lymphotropic virus type I (HTLV-I) provirus load in a rural West African population: no enhancement of human immunodeficiency virus type 2 pathogenesis, but HTLV-I provirus load relates to mortality.

Koya Ariyoshi, Neil Berry, Fatim Cham, Shabbar Jaffar, Maarten Schim van der Loeff, Ousman Jobe, Pa Tamba N'Gom, Olav Larsen, Sören Andersson, Peter Aaby, Hilton Whittle

Author Information

Koya Ariyoshi: Medical Research Council Laboratories, Fajara, The Gambia. ariyoshi@nih.go.jp.

PMID: 14639534 DOI: 10.1086/379780

Human T-lymphotropic virus type I (HTLV-I) provirus load was examined in a cohort of a population in Guinea-Bissau among whom human immunodeficiency virus (HIV) type 2 is endemic. Geometric mean of HIV-2 RNA load among HTLV-I-coinfected subjects was significantly lower than that in subjects infected with HIV-2 alone (212 vs. 724 copies/mL; P=.02). Adjusted for age, sex, and HIV status, the risk of death increased with HTLV-I provirus load; mortality hazard ratio was 1.59 for each log10 increase in HTLV-I provirus copies (P=.038). There is no enhancing effect of HTLV-I coinfection on HIV-2 disease, but high HTLV-I provirus loads may contribute to mortality.

Acquired Immunodeficiency Syndrome

Adult

CD4 Lymphocyte Count

Cohort Studies

Enzyme-Linked Immunosorbent Assay

Female

Guinea-Bissau

HIV-2

Human T-lymphotropic virus 1

Humans

Male

Middle Aged

Polymerase Chain Reaction

Proviruses

RNA, Viral

Viral Load

RNA, Viral

Journal Article Research Support, Non-U.S. Gov't

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