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Recent patents on anti-infective drug discovery
Jun, 2010;5 (2): 124-51.

Topical antimicrobials for burn wound infections.

T Dai, Y Y Huang, S K Sharma, J T Hashmi, D B Kurup, M R Hamblin
Author Information
  1. T Dai: Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA.
PMID: 20429870 DOI: 10.2174/157489110791233522

Abstract

Throughout most of history, serious burns occupying a large percentage of body surface area were an almost certain death sentence because of subsequent infection. A number of factors such as disruption of the skin barrier, ready availability of bacterial nutrients in the burn milieu, destruction of the vascular supply to the burned skin, and systemic disturbances lead to immunosuppression combined together to make burns particularly susceptible to infection. In the 20th century the introduction of antibiotic and antifungal drugs, the use of topical antimicrobials that could be applied to burns, and widespread adoption of early excision and grafting all helped to dramatically increase survival. However the relentless increase in microbial resistance to antibiotics and other antimicrobials has led to a renewed search for alternative approaches to prevent and combat burn infections. This review will cover patented strategies that have been issued or filed with regard to new topical agents, preparations, and methods of combating burn infections. Animal models that are used in preclinical studies are discussed. Various silver preparations (nanocrystalline and slow release) are the mainstay of many approaches but antimicrobial peptides, topical photodynamic therapy, chitosan preparations, new iodine delivery formulations, phage therapy and natural products such as honey and essential oils have all been tested. This active area of research will continue to provide new topical antimicrobials for burns that will battle against growing multidrug resistance.

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Grants

  1. R01 AI050875/NIAID NIH HHS
  2. R01 AI050875-07/NIAID NIH HHS
  3. R01AI050875/NIAID NIH HHS

MeSH Term

Administration, Topical
Animals
Anti-Infective Agents, Local
Antimicrobial Cationic Peptides
Burns
Chitosan
Disease Models, Animal
Drug Resistance, Microbial
Humans
Iodine
Models, Biological
Patents as Topic
Photochemotherapy
Silver
Skin, Artificial
Wound Infection

Chemicals

Anti-Infective Agents, Local
Antimicrobial Cationic Peptides
Silver
Chitosan
Iodine
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review
Article has an altmetric score of 14

Word Cloud

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