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Neuroimaging clinics of North America
Aug, 2010;20 (3): 293-310.

Imaging of brain tumors: MR spectroscopy and metabolic imaging.

Alena Horská, Peter B Barker
Author Information
  1. Alena Horská: Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA.
PMID: 20708548 DOI: 10.1016/j.nic.2010.04.003

Abstract

The utility of magnetic resonance spectroscopy (MRS) in diagnosis and evaluation of treatment response to human brain tumors has been widely documented. The role of MRS in tumor classification, tumors versus nonneoplastic lesions, prediction of survival, treatment planning, monitoring of therapy, and post-therapy evaluation is discussed. This article delineates the need for standardization and further study in order for MRS to become widely used as a routine clinical tool.

References

  1. J Neurooncol. 2009 Feb;91(3):337-51 [PMID: 19009235]
  2. J Magn Reson Imaging. 2001 Jan;13(1):12-5 [PMID: 11169797]
  3. Eur Radiol. 2008 Aug;18(8):1727-35 [PMID: 18389246]
  4. Neuroradiology. 2008 Sep;50(9):759-67 [PMID: 18523762]
  5. Radiology. 2003 May;227(2):529-37 [PMID: 12663825]
  6. Eur Radiol. 2001;11(9):1784-91 [PMID: 11511902]
  7. Recent Results Cancer Res. 2009;171:141-53 [PMID: 19322542]
  8. Proc Natl Acad Sci U S A. 1985 Apr;82(7):2148-52 [PMID: 3856889]
  9. AJNR Am J Neuroradiol. 2000 Oct;21(9):1645-9 [PMID: 11039343]
  10. AJNR Am J Neuroradiol. 1997 Oct;18(9):1695-704 [PMID: 9367317]
  11. Ann N Y Acad Sci. 1987;508:333-48 [PMID: 3326459]
  12. Magn Reson Med. 2003 Jan;49(1):29-36 [PMID: 12509817]
  13. J Magn Reson Imaging. 2001 Jul;14(1):8-15 [PMID: 11436208]
  14. Radiology. 2004 Mar;230(3):703-8 [PMID: 14739313]
  15. Neurosurgery. 2005 Apr;56(2 Suppl):291-8; discussion 291-8 [PMID: 15794826]
  16. Stereotact Funct Neurosurg. 2008;86(5):300-7 [PMID: 18791331]
  17. J Neurooncol. 2007 Mar;82(1):103-10 [PMID: 17031552]
  18. AJR Am J Roentgenol. 2009 Feb;192(2):W45-52 [PMID: 19155380]
  19. AJNR Am J Neuroradiol. 2007 Oct;28(9):1683-9 [PMID: 17893221]
  20. Neurosurgery. 2002 Oct;51(4):912-9; discussion 919-20 [PMID: 12234397]
  21. Nat Rev Clin Oncol. 2009 Nov;6(11):648-57 [PMID: 19806145]
  22. Radiology. 1989 Aug;172(2):541-8 [PMID: 2748837]
  23. BMC Cancer. 2007 Jul 27;7:141 [PMID: 17662122]
  24. NMR Biomed. 1990 Aug;3(4):184-9 [PMID: 2169842]
  25. Magn Reson Med. 1991 Jan;17(1):82-94 [PMID: 1648655]
  26. Neuroradiology. 2006 Sep;48(9):622-31 [PMID: 16752135]
  27. Neurosurgery. 2003 Sep;53(3):565-74; discussion 574-6 [PMID: 12943573]
  28. Nat Med. 1996 Mar;2(3):323-5 [PMID: 8612232]
  29. Nat Med. 2000 Nov;6(11):1287-9 [PMID: 11062544]
  30. J Magn Reson Imaging. 2002 Oct;16(4):464-76 [PMID: 12353260]
  31. Br J Radiol. 2006 Sep;79 Spec No 1:S16-26 [PMID: 16980681]
  32. Can J Neurol Sci. 1998 Feb;25(1):13-22 [PMID: 9532276]
  33. J Neurooncol. 2006 May;77(3):297-303 [PMID: 16314945]
  34. AJNR Am J Neuroradiol. 2002 Sep;23(8):1378-86 [PMID: 12223381]
  35. Radiology. 1990 Dec;177(3):633-41 [PMID: 2243962]
  36. Magn Reson Med. 1989 Jan;9(1):79-93 [PMID: 2540396]
  37. Ann Neurol. 1992 Mar;31(3):319-27 [PMID: 1637139]
  38. J Cancer Res Clin Oncol. 1999;125(6):343-9 [PMID: 10363566]
  39. Magn Reson Med. 2009 Dec;62(6):1646-51 [PMID: 19785020]
  40. J Magn Reson Imaging. 2004 Nov;20(5):772-8 [PMID: 15503328]
  41. J Neurooncol. 2006 Jan;76(2):185-91 [PMID: 16151595]
  42. AJNR Am J Neuroradiol. 2000 Feb;21(2):367-74 [PMID: 10696025]
  43. Expert Rev Neurother. 2008 Oct;8(10):1507-25 [PMID: 18928344]
  44. AJR Am J Roentgenol. 2007 Mar;188(3):710-4 [PMID: 17312058]
  45. Magn Reson Med. 2003 Feb;49(2):223-32 [PMID: 12541241]
  46. Neurosurgery. 2001 Oct;49(4):823-9 [PMID: 11564242]
  47. AJNR Am J Neuroradiol. 2001 Apr;22(4):604-12 [PMID: 11290466]
  48. Neuroradiology. 2004 Feb;46(2):126-9 [PMID: 14685797]
  49. Neurosurgery. 2009 Nov;65(5):908-13; discussion 913 [PMID: 19834403]
  50. NMR Biomed. 2008 Mar;21(3):233-41 [PMID: 17562554]
  51. AJNR Am J Neuroradiol. 2003 May;24(5):946-51 [PMID: 12748099]
  52. Neuroradiology. 2002 May;44(5):371-81 [PMID: 12012120]
  53. Clin Invest Med. 2006 Oct;29(5):301-11 [PMID: 17144440]
  54. J Neurosurg. 2002 Oct;97(4):794-802 [PMID: 12405365]
  55. Neurosurgery. 2004 May;54(5):1111-7; discussion 1117-9 [PMID: 15113465]
  56. NeuroRx. 2006 Apr;3(2):276-91 [PMID: 16554265]
  57. Radiology. 2007 May;243(2):539-50 [PMID: 17456876]
  58. J Neurooncol. 2000 Dec;50(3):215-26 [PMID: 11263501]
  59. J Neurooncol. 2009 Jan;91(1):69-81 [PMID: 18810326]
  60. Recent Results Cancer Res. 2009;171:125-40 [PMID: 19322541]
  61. Eur J Radiol. 2006 Oct;60(1):48-55 [PMID: 16844335]
  62. Magn Reson Imaging. 1989 Sep-Oct;7(5):547-55 [PMID: 2607903]
  63. Magn Reson Med. 2008 Jun;59(6):1457-66 [PMID: 18421692]
  64. J Neurosurg. 1997 Oct;87(4):516-24 [PMID: 9322842]
  65. Recent Results Cancer Res. 2009;171:175-90 [PMID: 19322545]
  66. J Neurooncol. 1993 Jul;17(1):27-35 [PMID: 8120569]
  67. AJNR Am J Neuroradiol. 2001 May;22(5):959-68 [PMID: 11337343]
  68. Ann Neurol. 1998 Aug;44(2):273-8 [PMID: 9708554]
  69. Top Magn Reson Imaging. 2004 Oct;15(5):291-313 [PMID: 15627004]
  70. Int J Radiat Oncol Biol Phys. 1998 Jan 15;40(2):279-86 [PMID: 9457810]
  71. AJNR Am J Neuroradiol. 1999 Aug;20(7):1252-7 [PMID: 10472982]
  72. Proc Natl Acad Sci U S A. 1982 Jun;79(11):3523-6 [PMID: 6954498]
  73. AJNR Am J Neuroradiol. 2009 Sep;30(8):1469-76 [PMID: 19369613]
  74. J Neurosurg. 2004 Sep;101(3):467-75 [PMID: 15352605]
  75. Magn Reson Med. 1995 Oct;34(4):508-14 [PMID: 8524016]
  76. J Neurosurg. 1997 Oct;87(4):525-34 [PMID: 9322843]
  77. NMR Biomed. 1994 May;7(3):149-55 [PMID: 8080717]
  78. Proc Natl Acad Sci U S A. 1988 Mar;85(6):1821-5 [PMID: 3162309]
  79. Radiographics. 2006 Oct;26 Suppl 1:S173-89 [PMID: 17050514]
  80. AJNR Am J Neuroradiol. 1995 Sep;16(8):1593-603 [PMID: 7502961]
  81. Br J Cancer. 2004 Feb 23;90(4):781-6 [PMID: 14970853]
  82. Neuroradiology. 2004 Aug;46(8):619-27 [PMID: 15243726]
  83. NMR Biomed. 1998 Jun-Aug;11(4-5):177-91 [PMID: 9719572]
  84. J Comput Assist Tomogr. 1990 Jul-Aug;14(4):497-504 [PMID: 2164536]
  85. J Magn Reson Imaging. 2006 Feb;23(2):99-107 [PMID: 16374884]
  86. Int J Radiat Oncol Biol Phys. 1996 Dec 1;36(5):1251-61 [PMID: 8985051]
  87. Brain Tumor Pathol. 2006 Apr;23(1):19-27 [PMID: 18095115]
  88. AJNR Am J Neuroradiol. 2001 Apr;22(4):613-24 [PMID: 11290467]
  89. Artif Intell Med. 2008 May;43(1):61-74 [PMID: 18448318]
  90. Clin Radiol. 2004 Jan;59(1):77-85 [PMID: 14697379]
  91. Int J Radiat Oncol Biol Phys. 2001 Jul 15;50(4):915-28 [PMID: 11429219]
  92. J Magn Reson Imaging. 2009 Feb;29(2):291-7 [PMID: 19161192]
  93. Lancet Neurol. 2006 Nov;5(11):937-48 [PMID: 17052661]
  94. Technol Cancer Res Treat. 2004 Dec;3(6):557-65 [PMID: 15560713]
  95. AJNR Am J Neuroradiol. 2008 Feb;29(2):366-72 [PMID: 18055564]
  96. Top Magn Reson Imaging. 1993 Winter;5(1):32-45 [PMID: 8416687]
  97. J Neurooncol. 2005 Jan;71(2):173-80 [PMID: 15690135]
  98. AJNR Am J Neuroradiol. 2000 Aug;21(7):1213-9 [PMID: 10954271]
  99. Magn Reson Med. 2002 Feb;47(2):384-7 [PMID: 11810683]
  100. Neurosurgery. 2000 Feb;46(2):306-18 [PMID: 10690719]
  101. Invest Radiol. 2007 Apr;42(4):218-23 [PMID: 17351427]
  102. AJNR Am J Neuroradiol. 2009 Mar;30(3):544-51 [PMID: 19095788]
  103. Int J Radiat Oncol Biol Phys. 2008 Mar 1;70(3):773-81 [PMID: 18262090]
  104. Ann Neurol. 2001 Apr;49(4):423-4 [PMID: 11310618]
  105. Int J Radiat Oncol Biol Phys. 2007 May 1;68(1):151-8 [PMID: 17289287]
  106. AJNR Am J Neuroradiol. 2005 Apr;26(4):760-9 [PMID: 15814918]
  107. Br J Radiol. 2002 Dec;75(900):959-66 [PMID: 12515704]
  108. J Clin Oncol. 2000 Mar;18(5):1020-6 [PMID: 10694552]
  109. J Neurooncol. 2009 May;92(3):401-15 [PMID: 19357966]
  110. Neuroradiology. 2005 Nov;47(11):826-34 [PMID: 16142479]
  111. Int J Oncol. 2007 Mar;30(3):651-7 [PMID: 17273766]

Grants

  1. P41 RR015241/NCRR NIH HHS
  2. P41 RR015241-060002/NCRR NIH HHS

MeSH Term

Brain
Brain Diseases
Brain Neoplasms
Diffusion Magnetic Resonance Imaging
Humans
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Neoplasm Invasiveness
Survival Analysis
Journal Article Research Support, N.I.H., Extramural Review
Article has an altmetric score of 6

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