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Neuron glia biology
Aug, 2010;6 (3): 141-6.

Synaptic plasticity and Ca2+ signalling in astrocytes.

Christian Henneberger, Dmitri A Rusakov
Author Information
  1. Christian Henneberger: UCL Institute of Neurology, University College London, Queen Square, London WC1N 2BG, UK. c.henneberger@ion.ucl.ac.uk
PMID: 20939938 DOI: 10.1017/S1740925X10000153

Abstract

There is a growing body of evidence suggesting a functional relationship between Ca2+ signals generated in astroglia and the functioning of nearby excitatory synapses. Interference with endogenous Ca2+ homeostasis inside individual astrocytes has been shown to affect synaptic transmission and its use-dependent changes. However, establishing the causal link between source-specific, physiologically relevant intracellular Ca2+ signals, the astrocytic release machinery and the consequent effects on synaptic transmission has proved difficult. Improved methods of Ca2+ monitoring in situ will be essential for resolving the ambiguity in understanding the underlying Ca2+ signalling cascades.

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Grants

  1. G0900613/Medical Research Council
  2. G0900613(91064)/Medical Research Council
  3. G0802216(89644)/Medical Research Council
  4. /Wellcome Trust
  5. G0802216/Medical Research Council
  6. 084311/Wellcome Trust

MeSH Term

Animals
Astrocytes
Calcium Signaling
Humans
Neuronal Plasticity
Synaptic Transmission
Journal Article Research Support, Non-U.S. Gov't Review
Article has an altmetric score of 1

Word Cloud

Created with Highcharts 10.0.0Ca2+signalsastrocytessynaptictransmissionsignallinggrowingbodyevidencesuggestingfunctionalrelationshipgeneratedastrogliafunctioningnearbyexcitatorysynapsesInterferenceendogenoushomeostasisinsideindividualshownaffectuse-dependentchangesHoweverestablishingcausallinksource-specificphysiologicallyrelevantintracellularastrocyticreleasemachineryconsequenteffectsproveddifficultImprovedmethodsmonitoringsituwillessentialresolvingambiguityunderstandingunderlyingcascadesSynapticplasticity

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