- Isabel Haro: Unit of Synthesis and Biomedical Applications of Peptides, Department of Biomedical Chemistry, IQAC-CSIC, Jordi Girona 18-26, Barcelona 08034, Spain. isabel.haro@iqac.csic.es
Preliminary studies have shown the potential application for the diagnosis of Rheumatoid Arthritis (RA) patients with a severe disease course of an epitopic domain of β-fibrin. The aim of the present work was the analysis of the presence of antibodies against several β-fibrin synthetic peptides in relation to the immunogenetic background and disease course in a clinically well-defined RA patient cohort. Our results indicated that positive patients against anti-β-fibrin synthetic peptides have a higher percentage of HLA-DRB1 shared epitope (SE) than negative patients. We also observed that the presence of SE alleles was significantly associated with a higher level of anti-[Cit(376)]βfib(365-383) antibodies. When analyzing the effect of different SE alleles, we found a significant positive association between carriers of QRRAA allele and [Cit(376)]βfib(365-383) (Odds ratio 3.77; CI95%: 1.41-10.08). These results suggest that the anti-β-fibrin status is associated with the immunogenetic background of RA patients.