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Cold Spring Harbor symposia on quantitative biology
2010;75 403-18.

Centromere identity, function, and epigenetic propagation across cell divisions.

B E Black, L E T Jansen, D R Foltz, D W Cleveland
Author Information
  1. B E Black: Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6059, USA. blackbe@mail.med.upenn.edu
PMID: 21467140 DOI: 10.1101/sqb.2010.75.038

Abstract

The key to understanding centromere identity is likely to lie in the chromatin containing the histone H3 variant CENP-A. CENP-A is the prime candidate to carry the epigenetic information that specifies the chromosomal location of the centromere in nearly all eukaryotic species, raising questions fundamental to understanding chromosome inheritance: How is the epigenetic centromere mark propagated? What physical properties of CENP-A-containing complexes are important for epigenetically marking centromeres? What are the molecules that recognize centromeric chromatin and serve as the foundation for the mitotic kinetochore? We discuss recent advances from our research groups that have yielded substantial insight into these questions and present our current understanding of the centromere. Future work promises an understanding of the molecular processes that confer fidelity to genome transmission at cell division.

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Grants

  1. R01 GM074150-06/NIGMS NIH HHS
  2. R01 GM082989/NIGMS NIH HHS
  3. R01 GM074150-07/NIGMS NIH HHS
  4. GM82989/NIGMS NIH HHS
  5. GM74150/NIGMS NIH HHS
  6. R01 GM074150/NIGMS NIH HHS

MeSH Term

Animals
Autoantigens
Cell Cycle
Cell Division
Centromere
Centromere Protein A
Chromatin
Chromosomal Proteins, Non-Histone
DNA Replication
Epigenesis, Genetic
Histones
Humans
Inheritance Patterns
Models, Biological
Models, Molecular
Nucleosomes
Protein Binding

Chemicals

Autoantigens
CENPA protein, human
Centromere Protein A
Chromatin
Chromosomal Proteins, Non-Histone
Histones
Nucleosomes
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Word Cloud

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