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Journal of clinical and experimental neuropsychology
2012;34 (2): 220-5.

Cerebral blood flow and neuropsychological functioning in elderly vascular disease patients.

David J Moser, Laura L Boles Ponto, Ivy N Miller, Susan K Schultz, Yusuf Menda, Stephan Arndt, Peggy C Nopoulos
Author Information
  1. David J Moser: Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA. david-moser@uiowa.edu
PMID: 22149630 DOI: 10.1080/13803395.2011.630653

Abstract

This study was designed to determine the relationships between positron emission tomography (PET)-based quantitative measures of cerebral blood flow and cerebrovascular reserve and neuropsychological functioning in elderly individuals with atherosclerotic vascular disease. It was hypothesized that cerebrovascular function would be significantly associated with neuropsychological functioning. Results showed that both baseline global cerebral blood flow and cerebrovascular reserve were significantly associated with global neuropsychological functioning, when controlling for age and sex. Cerebrovascular reserve was additionally associated with performance on measures of memory and attention. Additional research is needed to determine whether measures of cerebral blood flow can be used to predict cognitive decline.

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Grants

  1. M01 RR000059/NCRR NIH HHS
  2. K23 AG020649/NIA NIH HHS
  3. R03 AG024609/NIA NIH HHS
  4. RR00059/NCRR NIH HHS
  5. 1 R03 AG024609-01/NIA NIH HHS

MeSH Term

Aged
Cerebral Cortex
Cerebrovascular Circulation
Cognition Disorders
Female
Humans
Male
Middle Aged
Neuropsychological Tests
Positron-Emission Tomography
Vascular Diseases
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't
Article has an altmetric score of 3

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