Femtomolar detection of a cancer biomarker protein in serum with ultralow background current by anodic stripping voltammetry.

Muhammad J A Shiddiky, Prakash H Kithva, Sakandar Rauf, Matt Trau
Author Information
  1. Muhammad J A Shiddiky: Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, QLD 4072, Australia.

Abstract

An electrochemical immunosensor for the detection of a cancer biomarker protein in serum at femtomolar concentrations with ultralow background response has been developed, which consists of (i) a hydrophilic polyacrylic acid brush-modified indium tin oxide substrate as an antifouling substrate and (ii) a graphene-quantum dots-antibody 'bionanoconjugate' as a signal amplification label in voltammetric detection of targets in a glassy carbon electrode.

Word Cloud

Created with Highcharts 10.0.0detectioncancerbiomarkerproteinserumultralowbackgroundsubstrateelectrochemicalimmunosensorfemtomolarconcentrationsresponsedevelopedconsistshydrophilicpolyacrylicacidbrush-modifiedindiumtinoxideantifoulingiigraphene-quantumdots-antibody'bionanoconjugate'signalamplificationlabelvoltammetrictargetsglassycarbonelectrodeFemtomolarcurrentanodicstrippingvoltammetry

Similar Articles

Cited By