Using generic preference-based measures in mental health: psychometric validity of the EQ-5D and SF-6D.
Brendan Mulhern, Clara Mukuria, Michael Barkham, Martin Knapp, Sarah Byford, Djøra Soeteman, John Brazier
Author Information
Brendan Mulhern: Brendan Mulhern, MRes, Clara Mukuria, PhD, Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, UK; Michael Barkham, PhD, Centre for Psychological Services Research, Department of Psychology, University of Sheffield, UK; Martin Knapp, PhD, Centre for the Economics of Mental and Physical Health, King's College London, and Personal Social Services Research Unit, London School of Economics and Political Science, UK; Sarah Byford, PhD, Centre for the Economics of Mental and Physical Health, King's College London, UK; Djøra Soeteman, PhD, Center for Health Decision Science, Harvard School of Public Health, Boston, Massachusetts, USA; John Brazier, PhD, Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, UK.
Clara Mukuria: Brendan Mulhern, MRes, Clara Mukuria, PhD, Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, UK; Michael Barkham, PhD, Centre for Psychological Services Research, Department of Psychology, University of Sheffield, UK; Martin Knapp, PhD, Centre for the Economics of Mental and Physical Health, King's College London, and Personal Social Services Research Unit, London School of Economics and Political Science, UK; Sarah Byford, PhD, Centre for the Economics of Mental and Physical Health, King's College London, UK; Djøra Soeteman, PhD, Center for Health Decision Science, Harvard School of Public Health, Boston, Massachusetts, USA; John Brazier, PhD, Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, UK.
Michael Barkham: Brendan Mulhern, MRes, Clara Mukuria, PhD, Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, UK; Michael Barkham, PhD, Centre for Psychological Services Research, Department of Psychology, University of Sheffield, UK; Martin Knapp, PhD, Centre for the Economics of Mental and Physical Health, King's College London, and Personal Social Services Research Unit, London School of Economics and Political Science, UK; Sarah Byford, PhD, Centre for the Economics of Mental and Physical Health, King's College London, UK; Djøra Soeteman, PhD, Center for Health Decision Science, Harvard School of Public Health, Boston, Massachusetts, USA; John Brazier, PhD, Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, UK.
Martin Knapp: Brendan Mulhern, MRes, Clara Mukuria, PhD, Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, UK; Michael Barkham, PhD, Centre for Psychological Services Research, Department of Psychology, University of Sheffield, UK; Martin Knapp, PhD, Centre for the Economics of Mental and Physical Health, King's College London, and Personal Social Services Research Unit, London School of Economics and Political Science, UK; Sarah Byford, PhD, Centre for the Economics of Mental and Physical Health, King's College London, UK; Djøra Soeteman, PhD, Center for Health Decision Science, Harvard School of Public Health, Boston, Massachusetts, USA; John Brazier, PhD, Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, UK.
Sarah Byford: Brendan Mulhern, MRes, Clara Mukuria, PhD, Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, UK; Michael Barkham, PhD, Centre for Psychological Services Research, Department of Psychology, University of Sheffield, UK; Martin Knapp, PhD, Centre for the Economics of Mental and Physical Health, King's College London, and Personal Social Services Research Unit, London School of Economics and Political Science, UK; Sarah Byford, PhD, Centre for the Economics of Mental and Physical Health, King's College London, UK; Djøra Soeteman, PhD, Center for Health Decision Science, Harvard School of Public Health, Boston, Massachusetts, USA; John Brazier, PhD, Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, UK.
Djøra Soeteman: Brendan Mulhern, MRes, Clara Mukuria, PhD, Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, UK; Michael Barkham, PhD, Centre for Psychological Services Research, Department of Psychology, University of Sheffield, UK; Martin Knapp, PhD, Centre for the Economics of Mental and Physical Health, King's College London, and Personal Social Services Research Unit, London School of Economics and Political Science, UK; Sarah Byford, PhD, Centre for the Economics of Mental and Physical Health, King's College London, UK; Djøra Soeteman, PhD, Center for Health Decision Science, Harvard School of Public Health, Boston, Massachusetts, USA; John Brazier, PhD, Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, UK.
John Brazier: Brendan Mulhern, MRes, Clara Mukuria, PhD, Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, UK; Michael Barkham, PhD, Centre for Psychological Services Research, Department of Psychology, University of Sheffield, UK; Martin Knapp, PhD, Centre for the Economics of Mental and Physical Health, King's College London, and Personal Social Services Research Unit, London School of Economics and Political Science, UK; Sarah Byford, PhD, Centre for the Economics of Mental and Physical Health, King's College London, UK; Djøra Soeteman, PhD, Center for Health Decision Science, Harvard School of Public Health, Boston, Massachusetts, USA; John Brazier, PhD, Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, UK.
BACKGROUND: Generic preference-based measures (EuroQoL-5D (EQ-5D) and SF-6D) are used in the economic evaluation of mental health interventions. However, there are inconsistent findings regarding their psychometric properties. AIMS: To investigate the psychometric properties of the EQ-5D and SF-6D in different mental health conditions, using seven existing data-sets. METHOD: The construct validity and responsiveness of the measures were assessed in comparison with condition-specific indicators. RESULTS: Evidence for construct validity and responsiveness in common mental health and personality disorders was found (correlations 0.22-0.64; effect sizes 0.37-1.24; standardised response means 0.45-1.31). There was some evidence for validity in schizophrenia (correlations 0.05-0.43), but responsiveness was unclear. CONCLUSIONS: EQ-5D and SF-6D can be used in the economic evaluation of interventions for common mental health problems with some confidence. In schizophrenia, a preference-based measure focused on the impact of mental health should be considered.
