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Revista chilena de obstetricia y ginecologia
Jun, 2014;79 (3): 218-228.

[Regulation of uterine blood flow. II. Functions of estrogen and estrogen receptor α/β in genomic and non-genomic actions of the uterine endothelium].

Pastore R Mayra, Villalón L Rosalina, Gladys López, Jesús Iruretagoyena, Ronald Magness
Author Information
  1. Pastore R Mayra: Programa de Endocrinología y Fisiología Reproductiva, Universidad de Wisconsin-Madison, Wisconsin, USA ; Laboratorio de Investigación Perinatal, Departamento de Obstetricia y Ginecología y División de Ciencias de la Reproducción, Universidad de Wisconsin-Madison, Wisconsin, USA.
  2. Villalón L Rosalina: Programa de Endocrinología y Fisiología Reproductiva, Universidad de Wisconsin-Madison, Wisconsin, USA ; Laboratorio de Investigación Perinatal, Departamento de Obstetricia y Ginecología y División de Ciencias de la Reproducción, Universidad de Wisconsin-Madison, Wisconsin, USA.
  3. Gladys López: Laboratorio de Investigación Perinatal, Departamento de Obstetricia y Ginecología y División de Ciencias de la Reproducción, Universidad de Wisconsin-Madison, Wisconsin, USA ; Departamento Perinatal, Universidad de Wisconsin-Madison, Wisconsin, USA.
  4. Jesús Iruretagoyena: Departamento Perinatal, Universidad de Wisconsin-Madison, Wisconsin, USA ; Departamento de Obstetricia y Ginecología de la División de Medicina Materno-Fetal. Universidad de Wisconsin-Madison, Wisconsin, USA.
  5. Ronald Magness: Programa de Endocrinología y Fisiología Reproductiva, Universidad de Wisconsin-Madison, Wisconsin, USA ; Laboratorio de Investigación Perinatal, Departamento de Obstetricia y Ginecología y División de Ciencias de la Reproducción, Universidad de Wisconsin-Madison, Wisconsin, USA ; Departamento Perinatal, Universidad de Wisconsin-Madison, Wisconsin, USA ; Departamento de Ciencias de Animales, Universidad de Wisconsin-Madison, Wisconsin, USA.
PMID: 26113751 DOI: 10.4067/S0717-75262014000300011

Abstract

Pregnancy is marked by changes and cardiovascular adaptations that are important for the maintenance and growth of the placenta and fetus. During this period, the uterine vascular adaptations manifest changes that can be classified as short or long term and they related to adaptations for vasodilation, angiogenic or remodeling. Estrogen and the classical estrogen receptors (ERs), ER-α and ER-β, have been shown to be partially responsible for facilitating this dramatic increase in uterine blood flow needed during pregnancy. This literature review discusses the basis for structural diversity and functional selectivity of ERs by estrogen, the role of ERs on the genomic and non-genomic effects in endothelial cells of uterine arteries (UAEC). These themes integrate scientific knowledge about the molecular regulation of UAEC to maintain the physiological increase in uteroplacental perfusion observed during normal pregnancy.

References

  1. FEBS Lett. 1995 Mar 6;360(3):291-3 [PMID: 7533729]
  2. Mol Aspects Med. 2006 Aug;27(4):299-402 [PMID: 16914190]
  3. Cardiovasc Res. 2000 Jun;46(3):579-84 [PMID: 10912468]
  4. Hypertension. 2012 May;59(5):1052-9 [PMID: 22454479]
  5. Am J Obstet Gynecol. 1985 Feb 15;151(4):484-94 [PMID: 3883777]
  6. J Med Chem. 2000 Dec 28;43(26):4934-47 [PMID: 11150164]
  7. Endocrinology. 1999 Feb;140(2):800-4 [PMID: 9927308]
  8. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4659-63 [PMID: 15324884]
  9. J Biol Chem. 2006 Jun 30;281(26):17909-19 [PMID: 16648639]
  10. J Biol Chem. 2007 Aug 3;282(31):22278-88 [PMID: 17535799]
  11. Curr Biol. 1999 Jul 29-Aug 12;9(15):845-8 [PMID: 10469573]
  12. Mol Biol Cell. 2005 Jan;16(1):231-7 [PMID: 15496458]
  13. J Steroid Biochem. 1984 Jan;20(1):111-20 [PMID: 6538611]
  14. Circ Res. 1997 Sep;81(3):355-62 [PMID: 9285637]
  15. Steroids. 1999 May;64(5):310-9 [PMID: 10406480]
  16. Hypertension. 2010 Apr;55(4):1005-11 [PMID: 20212268]
  17. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14451-6 [PMID: 14610283]
  18. Endocr Rev. 2002 Oct;23(5):665-86 [PMID: 12372846]
  19. Semin Reprod Med. 2012 Jan;30(1):46-61 [PMID: 22271294]
  20. J Med Chem. 2009 Feb 12;52(3):858-67 [PMID: 19128016]
  21. Mol Endocrinol. 2003 Jan;17(1):1-10 [PMID: 12511601]
  22. J Cell Physiol. 2012 Jan;227(1):146-59 [PMID: 21374595]
  23. Biochem Biophys Res Commun. 2004 Apr 9;316(3):878-83 [PMID: 15033483]
  24. Steroids. 2002 May;67(6):413-9 [PMID: 11960616]
  25. EMBO J. 1986 May;5(5):891-7 [PMID: 3755102]
  26. Mol Cell Endocrinol. 2011 Mar 30;335(2):96-103 [PMID: 20615453]
  27. Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):703-8 [PMID: 12515851]
  28. J Nutr Sci Vitaminol (Tokyo). 2000 Aug;46(4):165-70 [PMID: 11185652]
  29. Am J Physiol. 1998 Sep;275(3 Pt 2):H731-43 [PMID: 9724274]
  30. Am J Obstet Gynecol. 1994 Sep;171(3):838-43 [PMID: 7522401]
  31. Am J Physiol. 1998 Nov;275(5 Pt 1):L843-51 [PMID: 9815100]
  32. Circ Res. 2000 Nov 24;87(11):E44-52 [PMID: 11090554]
  33. Endocrinology. 2000 Oct;141(10):3534-45 [PMID: 11014206]
  34. J Clin Endocrinol Metab. 2001 Mar;86(3):1370-8 [PMID: 11238534]
  35. Endocrinology. 1997 Mar;138(3):863-70 [PMID: 9048584]
  36. Am J Physiol Regul Integr Comp Physiol. 2003 Feb;284(2):R245-58 [PMID: 12529278]
  37. Circulation. 1995 Feb 1;91(3):755-63 [PMID: 7530174]
  38. Development. 2000 Oct;127(19):4277-91 [PMID: 10976058]
  39. J Biol Chem. 2003 Jan 24;278(4):2118-23 [PMID: 12431978]
  40. Essays Biochem. 2004;40:27-39 [PMID: 15242337]
  41. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1505-7 [PMID: 15713417]
  42. Endocrinology. 2004 Jan;145(1):113-25 [PMID: 14512434]
  43. Am J Physiol Heart Circ Physiol. 2002 Nov;283(5):H1819-28 [PMID: 12384459]
  44. J Clin Endocrinol Metab. 2006 Feb;91(2):569-79 [PMID: 16332939]
  45. J Med Chem. 2004 Oct 7;47(21):5021-40 [PMID: 15456246]
  46. Cytogenet Cell Genet. 1986;43(3-4):218-20 [PMID: 3802924]
  47. J Mol Cell Cardiol. 2007 Feb;42(2):271-9 [PMID: 16839566]
  48. J Physiol. 2005 May 15;565(Pt 1):71-83 [PMID: 15774510]
  49. Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2076-81 [PMID: 14764897]
  50. J Biol Chem. 2005 Mar 4;280(9):7460-8 [PMID: 15615701]
  51. J Clin Invest. 1999 Feb;103(3):401-6 [PMID: 9927501]
  52. Circ Res. 2000 Oct 13;87(8):677-82 [PMID: 11029403]
  53. Nucleic Acids Res. 1994 Nov 11;22(22):4673-80 [PMID: 7984417]
  54. Cardiovasc Res. 2007 Jan 1;73(1):217-26 [PMID: 17141206]
  55. Cancer Res. 1991 Aug 1;51(15):3867-73 [PMID: 1855205]
  56. Endocrinology. 2002 Mar;143(3):941-7 [PMID: 11861516]
  57. Mol Cell Endocrinol. 2001 Apr 25;175(1-2):41-56 [PMID: 11325515]
  58. J Biol Chem. 1996 Mar 15;271(11):6518-22 [PMID: 8626455]
  59. Mol Endocrinol. 2002 May;16(5):938-46 [PMID: 11981029]
  60. Am J Physiol. 1997 Jul;273(1 Pt 1):L119-26 [PMID: 9252548]
  61. Circulation. 1996 Sep 15;94(6):1402-7 [PMID: 8822999]
  62. J Biol Chem. 2000 Jun 23;275(25):19416-21 [PMID: 10787410]
  63. Am J Physiol. 1992 Jul;263(1 Pt 2):H188-97 [PMID: 1636758]
  64. J Med Chem. 2001 Nov 22;44(24):4230-51 [PMID: 11708925]
  65. J Med Chem. 2004 Nov 18;47(24):5872-93 [PMID: 15537344]
  66. J Clin Invest. 1997 May 15;99(10):2429-37 [PMID: 9153286]

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  1. R01 HL049210/NHLBI NIH HHS
  2. R01 HL117341/NHLBI NIH HHS
  3. R00 AA019446/NIAAA NIH HHS
  4. R25 GM083252/NIGMS NIH HHS
  5. K99 AA019446/NIAAA NIH HHS
  6. T32 HD041921/NICHD NIH HHS
  7. R01 HL087144/NHLBI NIH HHS
  8. P01 HD038843/NICHD NIH HHS
Journal Article English Abstract

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Created with Highcharts 10.0.0uterineestrogenadaptationsERschangesincreasebloodflowpregnancygenomicnon-genomicUAECPregnancymarkedcardiovascularimportantmaintenancegrowthplacentafetusperiodvascularmanifestcanclassifiedshortlongtermrelatedvasodilationangiogenicremodelingEstrogenclassicalreceptorsER-αER-βshownpartiallyresponsiblefacilitatingdramaticneededliteraturereviewdiscussesbasisstructuraldiversityfunctionalselectivityroleeffectsendothelialcellsarteriesthemesintegratescientificknowledgemolecularregulationmaintainphysiologicaluteroplacentalperfusionobservednormal[RegulationIIFunctionsreceptorα/βactionsendothelium]

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