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Comparative biochemistry and physiology. B, Comparative biochemistry
Jun, 1993;105 (2): 257-261.

RETINOID METABOLISM AND CONVERSION OF RETINOL TO DEHYDRORETINOL IN THE CRAYFISH () RETINA.

Tatsuo Suzsuki, Akihisa Terakita, Andrew T C Tsin
Author Information
  1. Tatsuo Suzsuki: Department of Pharmacology, Hyogo College of Medicine, Hyogo 663, Japan.
  2. Akihisa Terakita: Photodynamics Research Center, Institute of Physical and Chemical Research, Miyagi 981, Japan.
  3. Andrew T C Tsin: Division of Life Sciences, The University of Texas at San Antonio, San Antonio, TX 78249, U.S.A.
PMID: 26190886 DOI: 10.1016/0305-0491(93)90226-U

Abstract

Activities of retinylester hydrolase (REHase) and retinol dehydrogenase (RDHase) were detected in the crayfish retina which has two visual pigment chromophores and three stored retinoids.RDHase and 11- REHase activities were localized to rhabdomal fraction and enzymes were specific to 11- isomers of substrates. Overall reaction from retinylester to retinal was highly specific to 11- isomers and this reaction was not selective between retinol and dehydroretinol.When 11- [H]-retinol was incubated with retina homogenates, radioactivity was detected in 11- dehydroretinol.These results suggest that retinol is converted to dehydroretinol after hydrolysis of retinylesters.

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Grants

  1. R01 EY006438/NEI NIH HHS
  2. S06 GM008194/NIGMS NIH HHS
Journal Article

Word Cloud

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