[Analysis of Risk Factors for Cytomegalovirus Infection after Allogeneic Hematopoietic Stem Cell Transplantation].
Bing-Han Zou, Qin Zhang, Ya-Ru Xu, Zhuo-Qing Qiao, Yu-Hang Li, Jian-Lin Chen, Liang-Ding Hu, Bin Zhang, Hu Chen
Author Information
Bing-Han Zou: Department of Hematopoietic Stem Cell Transplantation, Affiliated Hospital of Academy of Military Medical Sciences; Institute of Hematopoietic Stem Cell of the Chinese PLA, Beijing 100071, China.
Qin Zhang: Department of Hematopoietic Stem Cell Transplantation, Affiliated Hospital of Academy of Military Medical Sciences; Institute of Hematopoietic Stem Cell of the Chinese PLA, Beijing 100071, China.
Ya-Ru Xu: Department of Hematopoietic Stem Cell Transplantation, Affiliated Hospital of Academy of Military Medical Sciences; Institute of Hematopoietic Stem Cell of the Chinese PLA, Beijing 100071, China.
Zhuo-Qing Qiao: Department of Hematopoietic Stem Cell Transplantation, Affiliated Hospital of Academy of Military Medical Sciences; Institute of Hematopoietic Stem Cell of the Chinese PLA, Beijing 100071, China.
Yu-Hang Li: Department of Hematopoietic Stem Cell Transplantation, Affiliated Hospital of Academy of Military Medical Sciences; Institute of Hematopoietic Stem Cell of the Chinese PLA, Beijing 100071, China.
Jian-Lin Chen: Department of Hematopoietic Stem Cell Transplantation, Affiliated Hospital of Academy of Military Medical Sciences; Institute of Hematopoietic Stem Cell of the Chinese PLA, Beijing 100071, China.
Liang-Ding Hu: Department of Hematopoietic Stem Cell Transplantation, Affiliated Hospital of Academy of Military Medical Sciences; Institute of Hematopoietic Stem Cell of the Chinese PLA, Beijing 100071, China.
Bin Zhang: Department of Hematopoietic Stem Cell Transplantation, Affiliated Hospital of Academy of Military Medical Sciences; Institute of Hematopoietic Stem Cell of the Chinese PLA, Beijing 100071, China. E-mail: zb307ctc@163.com.
Hu Chen: Department of Hematopoietic Stem Cell Transplantation, Affiliated Hospital of Academy of Military Medical Sciences; Institute of Hematopoietic Stem Cell of the Chinese PLA, Beijing 100071, China. E-mail: chenhu217@aliyun.com.
OBJECTIVE: To analyze the incidence of cytomegalovirus infection and related risk factors after allogeneic hematopoietic cell transplantation and to develop a rational strategy for the preemptive treatment of CMV infection. METHODS: The clinical data of 398 patients undergoing allogeneic hematopoietic cell transplantation from December 2011 to December 2014 were analyzed retrospectively by using a Kaplan Meier analysis and Logistics model. RESULTS: Out of 398 patients 233 developed post-transplant CMV infection (58.5%). Univariate analysis showed that HLA mismatch, ATG administration, acute graft versus host disease (aGVHD), using prednisone ≥ 1 mg/kg body weight or equivalent were associated with increase of CMV infection. Multivariate analysis showed that HLA mismatch (HR = 2.765, P = 0.000), ATG administration (HR = 3.866, P = 0.000), using prednisone ≥ 1 mg/kg body weight or equivalent (HR = 4.767, P = 0.000) also were associated with increase of CMV infection. CONCLUSION: HLA mismatch, ATG administration, using prednisone ≥ 1 mg/kg are risk factors for CMV reaction.
