[Intracoronary administration of antithrombotic agents via a perfusion balloon catheter in patients with ST-segment elevation myocardial infarction presenting with massive intraluminal thrombus and failed aspiration].
B Ajlani, G Gibault-Genty, G Cherif, E Blicq, S Azzaz, P Schiano, M Brami, L Sarfati, C Charbonnel, R Convers-Domart, B Livarek, J-L Georges
Author Information
B Ajlani: Service de cardiologie, unité de soins intensif cardiologiques et cardiologie interventionnelle, centre hospitalier de Versailles, hôpital André-Mignot, 177, rue de Versailles, 78150 Le Chesnay, France.
G Gibault-Genty: Service de cardiologie, unité de soins intensif cardiologiques et cardiologie interventionnelle, centre hospitalier de Versailles, hôpital André-Mignot, 177, rue de Versailles, 78150 Le Chesnay, France.
G Cherif: Service de cardiologie, unité de soins intensif cardiologiques et cardiologie interventionnelle, centre hospitalier de Versailles, hôpital André-Mignot, 177, rue de Versailles, 78150 Le Chesnay, France.
E Blicq: Service de cardiologie, unité de soins intensif cardiologiques et cardiologie interventionnelle, centre hospitalier de Versailles, hôpital André-Mignot, 177, rue de Versailles, 78150 Le Chesnay, France.
S Azzaz: Service de cardiologie, unité de soins intensif cardiologiques et cardiologie interventionnelle, centre hospitalier de Versailles, hôpital André-Mignot, 177, rue de Versailles, 78150 Le Chesnay, France.
P Schiano: Service de cardiologie, unité de soins intensif cardiologiques et cardiologie interventionnelle, centre hospitalier de Versailles, hôpital André-Mignot, 177, rue de Versailles, 78150 Le Chesnay, France.
M Brami: Service de cardiologie, unité de soins intensif cardiologiques et cardiologie interventionnelle, centre hospitalier de Versailles, hôpital André-Mignot, 177, rue de Versailles, 78150 Le Chesnay, France; Service de cardiologie, centre médico chirurgical de l'Europe, 78560 Le Port Marly, France.
L Sarfati: Service de cardiologie, unité de soins intensif cardiologiques et cardiologie interventionnelle, centre hospitalier de Versailles, hôpital André-Mignot, 177, rue de Versailles, 78150 Le Chesnay, France; Service de cardiologie, centre médico chirurgical de l'Europe, 78560 Le Port Marly, France.
C Charbonnel: Service de cardiologie, unité de soins intensif cardiologiques et cardiologie interventionnelle, centre hospitalier de Versailles, hôpital André-Mignot, 177, rue de Versailles, 78150 Le Chesnay, France.
R Convers-Domart: Service de cardiologie, unité de soins intensif cardiologiques et cardiologie interventionnelle, centre hospitalier de Versailles, hôpital André-Mignot, 177, rue de Versailles, 78150 Le Chesnay, France.
B Livarek: Service de cardiologie, unité de soins intensif cardiologiques et cardiologie interventionnelle, centre hospitalier de Versailles, hôpital André-Mignot, 177, rue de Versailles, 78150 Le Chesnay, France.
J-L Georges: Service de cardiologie, unité de soins intensif cardiologiques et cardiologie interventionnelle, centre hospitalier de Versailles, hôpital André-Mignot, 177, rue de Versailles, 78150 Le Chesnay, France. Electronic address: jgeorges@ch-versailles.fr.
BACKGROUND: Massive intracoronary thrombus is associated with adverse procedural results including failed aspiration and unfavourable reperfusion. We aim to evaluate the effect of the intracoronary administration of antithrombotic agents via a perfusion catheter in patients with ST-segment elevation myocardial infarction (STEMI) presenting with a large thrombus burden and failed aspiration. METHODS: We retrospectively analyzed the thrombus burden, the TIMI grade flow, and the myocardial Blush in 25 consecutive STEMI patients with a large thrombus burden and failed manual aspiration, who received intracoronary infusion of glycoprotein IIb/IIIa inhibitors (N=17) or bivalirudine (N=8) via a 6F-infusion catheter (ClearWay™ RX) RESULTS: Mean age was 67±14 years, 16 patients (64 %) presented with anterior STEMI, and 7 (28 %) with cardiogenic shock. Immediately after intracoronary infusion, the TIMI flow grade improved of 2 grades in 7 patients (28 %), and 1 grade in 14 (56 %), a complete resolution of the thrombus was observed in 9 patients, and a >50 % resolution in 12. Blush was improved of 3 grades in 15 patients (60 %), of 2 grades in 7 (28 %), and Blush grade 0 remained in 3. At the end of procedure, we observed normal TIMI 3flow in most patients (92 %), a complete resolution of thrombus in 80 %, and a Blush grade 3 in 68 %. CONCLUSIONS: In STEMI patients presenting with a large thrombus burden and failed aspiration, intracoronary administration of glycoprotein IIb/IIIa inhibitors or bivalirudin via the perfusion catheter ClearWay™ RX significantly reduced the thrombus burden and improved the TIMI flow and the Blush grade, without bleeding.
