OpenLB
Open Library of Bioscience
Advanced Search
Current topics in medicinal chemistry
2017;17 (21): 2433-2439.

Microbial Routes to (2R,3R)-2,3-Butanediol: Recent Advances and Future Prospects.

Neng-Zhong Xie, Xian-Rui Chen, Qing-Yan Wang, Dong Chen, Qi-Shi Du, Guo-Ping Zhou, Ri-Bo Huang
Author Information
  1. Neng-Zhong Xie: National Engineering Research Center for Non-food Biorefinery, State Key Laboratory of Non-food Biomass Energy and Enzyme Technology, Guangxi Biomass Industrialization Engineering Institute, and Guangxi Key Laboratory of Biorefinery, Guangxi Academy of Sciences, No. 98 Daling Road, Nanning, 530007, Guangxi, China.
  2. Xian-Rui Chen: National Engineering Research Center for Non-food Biorefinery, State Key Laboratory of Non-food Biomass Energy and Enzyme Technology, Guangxi Biomass Industrialization Engineering Institute, and Guangxi Key Laboratory of Biorefinery, Guangxi Academy of Sciences, No. 98 Daling Road, Nanning, 530007, Guangxi, China.
  3. Qing-Yan Wang: National Engineering Research Center for Non-food Biorefinery, State Key Laboratory of Non-food Biomass Energy and Enzyme Technology, Guangxi Biomass Industrialization Engineering Institute, and Guangxi Key Laboratory of Biorefinery, Guangxi Academy of Sciences, No. 98 Daling Road, Nanning, 530007, Guangxi, China.
  4. Dong Chen: National Engineering Research Center for Non-food Biorefinery, State Key Laboratory of Non-food Biomass Energy and Enzyme Technology, Guangxi Biomass Industrialization Engineering Institute, and Guangxi Key Laboratory of Biorefinery, Guangxi Academy of Sciences, No. 98 Daling Road, Nanning, 530007, Guangxi, China.
  5. Qi-Shi Du: National Engineering Research Center for Non-food Biorefinery, State Key Laboratory of Non-food Biomass Energy and Enzyme Technology, Guangxi Biomass Industrialization Engineering Institute, and Guangxi Key Laboratory of Biorefinery, Guangxi Academy of Sciences, No. 98 Daling Road, Nanning, 530007, Guangxi, China.
  6. Guo-Ping Zhou: National Engineering Research Center for Non-food Biorefinery, State Key Laboratory of Non-food Biomass Energy and Enzyme Technology, Guangxi Biomass Industrialization Engineering Institute, and Guangxi Key Laboratory of Biorefinery, Guangxi Academy of Sciences, No. 98 Daling Road, Nanning, 530007, Guangxi, China.
  7. Ri-Bo Huang: National Engineering Research Center for Non-food Biorefinery, State Key Laboratory of Non-food Biomass Energy and Enzyme Technology, Guangxi Biomass Industrialization Engineering Institute, and Guangxi Key Laboratory of Biorefinery, Guangxi Academy of Sciences, No. 98 Daling Road, Nanning, 530007, Guangxi, China.
PMID: 28474550 DOI: 10.2174/1568026617666170504101646

Abstract

(2R,3R)-2,3-Butanediol has many industrial applications, such as it is used as an antifreeze agent and low freezing point fuel. In addition, it is particularly important to provide chiral groups in drugs. In recent years, this valuable bio-based chemical has attracted increasing attention, and significant progress has been made in the development of microbial cell factories for (2R,3R)-2,3-butanediol production. This article reviews recent advances and challenges in microbial routes to (2R,3R)-2,3- butanediol production, and highlights the metabolic engineering and synthetic biological approaches used to improve titers, yields, productivities, and optical purities. Finally, a systematic and integrative strategy for developing high-performance microbial cell factories is proposed.

Keywords

(2R 3-Butanediol 3R)-2 Metabolic engineering Microbial cell factory Rational design Synthetic biology Systematicand Integrative strategy

MeSH Term

Bacillus subtilis
Butylene Glycols
Metabolic Engineering
Paenibacillus polymyxa

Chemicals

Butylene Glycols
2,3-butylene glycol
Journal Article Review

Word Cloud

Created with Highcharts 10.0.02R3R-2microbialcell3-ButanediolusedrecentfactoriesproductionengineeringstrategyMicrobialmanyindustrialapplicationsantifreezeagentlowfreezingpointfueladditionparticularlyimportantprovidechiralgroupsdrugsyearsvaluablebio-basedchemicalattractedincreasingattentionsignificantprogressmadedevelopment3-butanediolarticlereviewsadvanceschallengesroutes3-butanediolhighlightsmetabolicsyntheticbiologicalapproachesimprovetitersyieldsproductivitiesopticalpuritiesFinallysystematicintegrativedevelopinghigh-performanceproposedRoutes3-Butanediol:RecentAdvancesFutureProspectsMetabolicfactoryRationaldesignSyntheticbiologySystematicandIntegrative

Similar Articles

Cited By