Facilitating engagement with PrEP and other HIV prevention technologies through practice-based combination prevention.

Morten Skovdal
Author Information
  1. Morten Skovdal: Department of Public Health, University of Copenhagen, Copenhagen, Denmark.

Abstract

INTRODUCTION: Recent years have witnessed a rapid expansion of efficacious biomedical HIV prevention technologies. Promising as they may be, they are largely delivered through standard, clinic-based models, often in isolation from structural and behavioural interventions. This contributes to varied, and often poor, uptake and adherence. There is a critical need to develop analytical tools that can advance our understandings and responses to the combination of interventions that affect engagement with HIV prevention technologies. This commentary makes a call for practice-based combination HIV prevention analysis and action, and presents a tool to facilitate this challenging but crucial endeavour.
DISCUSSION: Models and frameworks for combination HIV prevention already exist, but the process of identifying precisely what multi-level factors that need to be considered as part of a combination of HIV interventions for particular populations and settings is unclear. Drawing on contemporary social practice theory, this paper develops a "table of questioning" to help interrogate the chain and combination of multi-level factors that shape engagement with HIV prevention technologies. The tool also supports an examination of other shared social practices, which at different levels, and in different ways, affect engagement with HIV prevention technologies. It facilitates an analysis of the range of factors and social practices that need to be synchronized in order to establish engagement with HIV prevention technologies as a possible and desirable thing to do. Such analysis can help uncover local hitherto un-identified issues and provide a platform for novel synergistic approaches for action that are not otherwise obvious. The tool is discussed in relation to PrEP among adolescent girls and young women in sub-Saharan Africa.
CONCLUSIONS: By treating engagement with HIV prevention technologies as a social practice and site of analysis and public health action, HIV prevention service planners and evaluators can identify and respond to the combination of factors and social practices that interact to form the context that supports or prohibits engagement with HIV prevention technologies for particular populations.

Keywords

References

  1. J Acquir Immune Defic Syndr. 2017 Nov 1;76(3):259-265 [PMID: 28777265]
  2. Am J Public Health. 2013 Aug;103(8):1367-75 [PMID: 23763397]
  3. AIDS Behav. 2019 Jul;23(7):1780-1789 [PMID: 30284653]
  4. AIDS Behav. 2019 Aug;23(8):2199-2209 [PMID: 30569314]
  5. PLoS Med. 2005 Nov;2(11):e298 [PMID: 16231970]
  6. AIDS Behav. 2010 Dec;14(Suppl 2):222-38 [PMID: 20838871]
  7. PLoS One. 2018 Dec 26;13(12):e0208689 [PMID: 30586376]
  8. Science. 2010 Sep 3;329(5996):1168-74 [PMID: 20643915]
  9. AIDS Behav. 2018 Feb;22(2):447-453 [PMID: 27943000]
  10. SAHARA J. 2018 Dec;15(1):179-186 [PMID: 30360675]
  11. N Engl J Med. 2015 Feb 5;372(6):509-18 [PMID: 25651245]
  12. Curr Opin HIV AIDS. 2016 Jan;11(1):80-6 [PMID: 26575147]
  13. BMJ. 2017 Dec 11;359:j5011 [PMID: 29229609]
  14. AIDS Care. 2018 Sep;30(9):1071-1082 [PMID: 29566546]
  15. AIDS Behav. 2018 Nov;22(11):3692-3704 [PMID: 29909589]
  16. N Engl J Med. 2012 Aug 2;367(5):411-22 [PMID: 22784040]
  17. AIDS Behav. 2017 May;21(5):1256-1267 [PMID: 27885552]
  18. J Acquir Immune Defic Syndr. 2014 Aug 15;66 Suppl 3:S250-8 [PMID: 25007194]
  19. Lancet. 2008 Aug 30;372(9640):764-75 [PMID: 18687460]
  20. J Int Assoc Provid AIDS Care. 2019 Jan-Dec;18:2325958219831011 [PMID: 30776954]
  21. Lancet HIV. 2016 Jul;3(7):e318-22 [PMID: 27365206]
  22. Curr HIV/AIDS Rep. 2019 Feb;16(1):120-128 [PMID: 30707399]
  23. Lancet HIV. 2016 Jul;3(7):e297-306 [PMID: 27365204]
  24. N Engl J Med. 2016 Sep 1;375(9):830-9 [PMID: 27424812]
  25. Cult Health Sex. 2017 Nov;19(11):1268-1285 [PMID: 28423992]
  26. AIDS Behav. 2010 Dec;14(Suppl 2):204-21 [PMID: 20862606]
  27. PLoS One. 2015 Apr 13;10(4):e0125458 [PMID: 25867624]
  28. J Int AIDS Soc. 2019 Jul;22 Suppl 4:e25294 [PMID: 31328412]
  29. Front Public Health. 2018 Aug 31;6:231 [PMID: 30234083]
  30. J Sex Res. 2007 Nov;44(4):380-94 [PMID: 18321017]
  31. J Int AIDS Soc. 2018 Aug;21(8):e25156 [PMID: 30101439]
  32. Curr HIV/AIDS Rep. 2015 Mar;12(1):127-38 [PMID: 25600106]
  33. Afr J AIDS Res. 2016 Jul;15(2):109-21 [PMID: 27399041]
  34. J Int AIDS Soc. 2016 Oct 18;19(7(Suppl 6)):21101 [PMID: 27760680]
  35. AIDS. 2014 Nov 28;28(18):2721-7 [PMID: 25493598]
  36. PLoS One. 2018 Dec 7;13(12):e0208167 [PMID: 30532210]
  37. Lancet. 2016 Jan 2;387(10013):53-60 [PMID: 26364263]
  38. N Engl J Med. 2016 Dec;375(22):2133-2143 [PMID: 27959766]
  39. J Int AIDS Soc. 2019 Jul;22 Suppl 4:e25309 [PMID: 31328375]
  40. AIDS Behav. 2013 Jul;17(6):2143-55 [PMID: 23435697]
  41. AIDS Care. 2018 Oct;30(10):1311-1314 [PMID: 29914270]
  42. J Int AIDS Soc. 2015 Dec 14;18:20499 [PMID: 26673880]
  43. PLoS One. 2018 Apr 27;13(4):e0196280 [PMID: 29702659]
  44. J Int AIDS Soc. 2012 Apr 26;15(2):17357 [PMID: 22713254]

Grants

  1. OPP124589/Bill & Melinda Gates Foundation

MeSH Term

Anti-HIV Agents
Female
HIV Infections
Humans
Pre-Exposure Prophylaxis

Chemicals

Anti-HIV Agents

Word Cloud

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