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Current protocols in bioinformatics
09, 2019;67 (1): e82.

Community Curation and Expert Curation of Human Long Noncoding RNAs with LncRNAWiki and LncBook.

Lina Ma, Jiabao Cao, Lin Liu, Zhao Li, Huma Shireen, Nashaiman Pervaiz, Fatima Batool, Rabail Z Raza, Dong Zou, Yiming Bao, Amir A Abbasi, Zhang Zhang
Author Information
  1. Lina Ma: BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
  2. Jiabao Cao: BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
  3. Lin Liu: BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
  4. Zhao Li: BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
  5. Huma Shireen: National Center for Bioinformatics, Programme of Comparative and Evolutionary Genomics, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
  6. Nashaiman Pervaiz: National Center for Bioinformatics, Programme of Comparative and Evolutionary Genomics, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
  7. Fatima Batool: National Center for Bioinformatics, Programme of Comparative and Evolutionary Genomics, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
  8. Rabail Z Raza: National Center for Bioinformatics, Programme of Comparative and Evolutionary Genomics, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
  9. Dong Zou: BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
  10. Yiming Bao: BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
  11. Amir A Abbasi: National Center for Bioinformatics, Programme of Comparative and Evolutionary Genomics, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
  12. Zhang Zhang: BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
PMID: 31524988 DOI: 10.1002/cpbi.82

Abstract

In recent years, the number of human long noncoding RNAs (lncRNAs) that have been identified has increased exponentially. However, these lncRNAs are poorly annotated compared to protein-coding genes, posing great challenges for a better understanding of their functional significance and elucidating their complex functioning molecular mechanisms. Here we employ both community and expert curation to yield a comprehensive collection of human lncRNAs and their annotations. Specifically, LncRNAWiki (http://lncrna.big.ac.cn/index.php/Main_Page) uses a wiki-based community curation model, thus showing great promise in dealing with the flood of biological knowledge, while LncBook (http://bigd.big.ac.cn/lncbook) is an expert curation-based database that provides a complement to LncRNAWiki. LncBook features a comprehensive collection of human lncRNAs and a systematic curation of lncRNAs by multi-omics data integration, functional annotation, and disease association. These protocols provide step-by-step instructions on how to browse and search a specific lncRNA and how to obtain a range of related information including expression, methylation, variation, function, and disease association. © 2019 by John Wiley & Sons, Inc.

Keywords

community curation disease expert curation long noncoding RNA multi-omics data

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MeSH Term

Community-Based Participatory Research
Data Management
Databases, Nucleic Acid
Humans
Molecular Sequence Annotation
RNA, Long Noncoding

Chemicals

RNA, Long Noncoding
Journal Article Research Support, Non-U.S. Gov't

Links to CNCB-NGDC Resources

Database Commons: DBC000026 (LncRNAWiki)

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