OpenLB Open Library of Bioscience

Community Curation and Expert Curation of Human Long Noncoding RNAs with LncRNAWiki and LncBook.

Lina Ma, Jiabao Cao, Lin Liu, Zhao Li, Huma Shireen, Nashaiman Pervaiz, Fatima Batool, Rabail Z Raza, Dong Zou, Yiming Bao, Amir A Abbasi, Zhang Zhang
Author Information
  1. Lina Ma: BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
  2. Jiabao Cao: BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
  3. Lin Liu: BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
  4. Zhao Li: BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
  5. Huma Shireen: National Center for Bioinformatics, Programme of Comparative and Evolutionary Genomics, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
  6. Nashaiman Pervaiz: National Center for Bioinformatics, Programme of Comparative and Evolutionary Genomics, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
  7. Fatima Batool: National Center for Bioinformatics, Programme of Comparative and Evolutionary Genomics, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
  8. Rabail Z Raza: National Center for Bioinformatics, Programme of Comparative and Evolutionary Genomics, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
  9. Dong Zou: BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
  10. Yiming Bao: BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
  11. Amir A Abbasi: National Center for Bioinformatics, Programme of Comparative and Evolutionary Genomics, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
  12. Zhang Zhang: BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.

Abstract

In recent years, the number of human long noncoding RNAs (lncRNAs) that have been identified has increased exponentially. However, these lncRNAs are poorly annotated compared to protein-coding genes, posing great challenges for a better understanding of their functional significance and elucidating their complex functioning molecular mechanisms. Here we employ both community and expert curation to yield a comprehensive collection of human lncRNAs and their annotations. Specifically, LncRNAWiki (http://lncrna.big.ac.cn/index.php/Main_Page) uses a wiki-based community curation model, thus showing great promise in dealing with the flood of biological knowledge, while LncBook (http://bigd.big.ac.cn/lncbook) is an expert curation-based database that provides a complement to LncRNAWiki. LncBook features a comprehensive collection of human lncRNAs and a systematic curation of lncRNAs by multi-omics data integration, functional annotation, and disease association. These protocols provide step-by-step instructions on how to browse and search a specific lncRNA and how to obtain a range of related information including expression, methylation, variation, function, and disease association. © 2019 by John Wiley & Sons, Inc.

Keywords

MeSH Term

Community-Based Participatory Research
Data Management
Databases, Nucleic Acid
Humans
Molecular Sequence Annotation
RNA, Long Noncoding

Chemicals

RNA, Long Noncoding