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Dermatitis : contact, atopic, occupational, drug
2021 Jul-Aug 01;32 (4): 267-272.

Frequency of Allergenic Ingredients in Antifungal Creams.

Nicole Ufkes, Wasim Haidari, Jennifer Su, Sarah Chisolm, Steven R Feldman
Author Information
  1. Nicole Ufkes: From the Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
  2. Wasim Haidari: From the Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
  3. Jennifer Su: From the Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
  4. Sarah Chisolm: Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia.
PMID: 32209867 DOI: 10.1097/DER.0000000000000588

Abstract

BACKGROUND: Allergic contact dermatitis (ACD) may occur secondary to topical antifungals containing potential allergens in their vehicles. Variation of allergenic ingredients among commonly used antifungal creams (AFCs) has not been well characterized.
OBJECTIVE: The study goal was to assess the frequency of allergenic ingredients in 4 commonly used topical AFCs.
METHODS: Topical AFCs (clotrimazole, ketoconazole, miconazole, and terbinafine) were selected, and the ingredient lists for these products were obtained from the US Food and Drug Administration's Online Label Repository via a proprietary name search. A systematic literature review was performed using the ingredient name on MEDLINE (PubMed) database to identify reports of ACD confirmed by patch testing.
RESULTS: Of the 20 ingredients analyzed, 6 had frequent allergenic potential. Propylene glycol was the most common cause of ACD identified in the literature and is an ingredient in ketoconazole 2% and miconazole nitrate 2%. Ketoconazole 2% and miconazole nitrate 2% creams contained the highest number of potential allergens (n = 3) among the 4 creams analyzed.
CONCLUSIONS: Of the 4 creams, terbinafine hydrochloride 1% and clotrimazole 1% contained the least number of potential allergenic ingredients. Awareness of the allergenic potential of commonly used AFCs may help health care providers when evaluating patients with ACD.

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MeSH Term

Administration, Topical
Allergens
Antifungal Agents
Dermatitis, Allergic Contact
Skin Cream

Chemicals

Allergens
Antifungal Agents
Journal Article
Article has an altmetric score of 1

Word Cloud

Created with Highcharts 10.0.0potentialallergenicACDingredientscreamsAFCs2%commonlyused4miconazoleingredientmaytopicalallergensamongclotrimazoleketoconazoleterbinafinenameliteratureanalyzednitratecontainednumber1%BACKGROUND:AllergiccontactdermatitisoccursecondaryantifungalscontainingvehiclesVariationantifungalwellcharacterizedOBJECTIVE:studygoalassessfrequencyMETHODS:TopicalselectedlistsproductsobtainedUSFoodDrugAdministration'sOnlineLabelRepositoryviaproprietarysearchsystematicreviewperformedusingMEDLINEPubMeddatabaseidentifyreportsconfirmedpatchtestingRESULTS:206frequentPropyleneglycolcommoncauseidentifiedKetoconazolehighestn=3CONCLUSIONS:hydrochlorideleastAwarenesshelphealthcareprovidersevaluatingpatientsFrequencyAllergenicIngredientsAntifungalCreams

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