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The Laryngoscope
08, 2020;130 (8): 1973-1979.

Prognostic Significance of Lymph Node Status in p16+ Oropharyngeal Cancer After Surgical Treatment.

Young Min Park, Tae Seong Eo, Yoon Woo Koh, Se-Heon Kim, Eun Chang Choi
Author Information
  1. Young Min Park: Department of Otorhinolaryngology, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul, South Korea. ORCID
  2. Tae Seong Eo: Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea.
  3. Yoon Woo Koh: Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea. ORCID
  4. Se-Heon Kim: Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea. ORCID
  5. Eun Chang Choi: Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea.
PMID: 32282081 DOI: 10.1002/lary.28665

Abstract

OBJECTIVES/HYPOTHESIS: In this study, we retrospectively reviewed medical records of patients who underwent surgery for p16+ oropharyngeal cancer and analyzed the prognostic implications of pathologic lymph node (LN) status, including number of metastatic LNs, LN ratio, and location of metastatic LNs.
STUDY DESIGN: Retrospective case series.
METHODS: We retrospectively reviewed data on patients diagnosed with p16+ oropharyngeal cancer.
RESULTS: The study population consisted of 159 males and 29 females with a mean age of 57.2 years. The primary tumor sites were tonsils (n = 160), base of the tongue (n = 24), and soft palate (n = 4). Only recurrence-free survival (RFS) showed a significant correlation with contralateral LN metastasis on multivariate analysis. On Kaplan-Meier analysis, 5-year RFS was 92.4% in patients without contralateral LN metastasis and 68.8% in patients with contralateral LN metastasis.
CONCLUSIONS: Among pathologic LN status in p16+ oropharyngeal cancer, only contralateral LN metastasis showed prognostic significance in disease recurrence of p16+ oropharyngeal squamous cell carcinoma patients.
LEVEL OF EVIDENCE: 4 Laryngoscope, 130: 1973-1979, 2020.

Keywords

Human papillomavirus LN metastasis oropharyngeal carcinoma prognosis

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MeSH Term

Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell
Female
Humans
Lymphatic Metastasis
Male
Middle Aged
Neoplasm Staging
Oropharyngeal Neoplasms
Prognosis
Retrospective Studies
Journal Article Research Support, Non-U.S. Gov't

Word Cloud

Created with Highcharts 10.0.0LNpatientsp16+oropharyngealmetastasiscontralateralcancern=studyretrospectivelyreviewedprognosticpathologicstatusmetastaticLNs4RFSshowedanalysiscarcinomaOBJECTIVES/HYPOTHESIS:medicalrecordsunderwentsurgeryanalyzedimplicationslymphnodeincludingnumberratiolocationSTUDYDESIGN:RetrospectivecaseseriesMETHODS:datadiagnosedRESULTS:populationconsisted159males29femalesmeanage572 yearsprimarytumorsitestonsils160basetongue24softpalaterecurrence-freesurvivalsignificantcorrelationmultivariateKaplan-Meier5-year924%without688%CONCLUSIONS:AmongsignificancediseaserecurrencesquamouscellLEVELOFEVIDENCE:Laryngoscope130:1973-19792020PrognosticSignificanceLymphNodeStatusOropharyngealCancerSurgicalTreatmentHumanpapillomavirusprognosis

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