Virtual reality approaches to pain: toward a state of the science.

Zina Trost, Christopher France, Monima Anam, Corey Shum
Author Information
  1. Zina Trost: Virginia Commonwealth University, Richmond, VA, United States.
  2. Christopher France: Ohio University, Athens, OH, United States.
  3. Monima Anam: University of Alabama at Birmingham, Birmingham, AL, United States.
  4. Corey Shum: Immersive Experience Labs, LLC, Birmingham, AL, United States.

Abstract

No abstract text available.

References

  1. Agrawal AK, Robertson S, Litwin L, Tringale E, Treadwell M, Hoppe C, Marsh A. Virtual reality as complementary pain therapy in hospitalized patients with sickle cell disease. Pediatr Blood Cancer 2019;66:e27525.
  2. Alemanno F, Houdayer E, Emedoli D, Locatelli M, Mortini P, Mandelli C, Raggi A, Iannaccone S. Efficacy of virtual reality to reduce chronic low back pain: proof-of-concept of a non-pharmacological approach on pain, quality of life, neuropsychological and functional outcome. PLoS One 2019;14:e0216858.
  3. Allam A, Kostova Z, Nakamoto K, Schulz PJ. The effect of social support features and gamification on a Web-based intervention for rheumatoid arthritis patients: randomized controlled trial. J Med Internet Res 2015;17:e14.
  4. Alshatrat SM, Alotaibi R, Sirois M, Malkawi Z. The use of immersive virtual reality for pain control during periodontal scaling and root planing procedures in dental hygiene clinic. Int J Dent Hyg 2019;17:71–6.
  5. Andreatta PB, Maslowski E, Petty S, Shim W, Marsh M, Hall T, Stern S, Frankel J. Virtual reality triage training provides a viable solution for disaster-preparedness. Acad Emerg Med 2010;17:870–6.
  6. Asl Aminabadi N, Erfanparast L, Sohrabi A, Ghertasi Oskouei S, Naghili A. The impact of virtual reality distraction on pain and anxiety during dental treatment in 4-6 Year-old children: a randomized controlled clinical trial. J Dent Res Dent Clin Dent Prospects 2012;6:117–24.
  7. Aternali A, Katz J. Recent advances in understanding and managing phantom limb pain. F1000Research 2019;8:1167.
  8. Atzori B, Hoffman HG, Vagnoli L, Patterson DR, Alhalabi W, Messeri A, Lauro Grotto R. Virtual reality analgesia during venipuncture in pediatric patients with onco-hematological diseases. Front Psychol 2018;9:2508.
  9. Austin P, Lovell M, Siddall P. The efficacy of virtual reality for persistent cancer pain: a call for research. J Pain Symptom Manage 2019;58:e11–14.
  10. Austin PD, Siddall PJ. Virtual reality for the treatment of neuropathic pain in people with spinal cord injuries: a scoping review. J Spinal Cord Med 2019:1–11.
  11. Bani Mohammad E, Ahmad M. Virtual reality as a distraction technique for pain and anxiety among patients with breast cancer: a randomized control trial. Palliat Support Care 2019;17:29–34.
  12. Benham S, Kang M, Grampurohit N. Immersive virtual reality for the management of pain in community-dwelling older adults. OTJR (Thorofare N J) 2019;39:90–6.
  13. Botella C, Garcia-Palacios A, Vizcaino Y, Herrero R, Banos RM, Belmonte MA. Virtual reality in the treatment of fibromyalgia: a pilot study. Cyberpsychol Behav Soc Netw 2013;16:215–23.
  14. Burdea GC, Coifett P. Virtual Reality Technology, 2nd Edition|Wiley. 2nd ed Hoboken: John Wiley & Sons, 2003. Available at: https://www.wiley.com/en-us/Virtual+Reality+Technology%2C+2nd+Edition-p-9780471360896 . Accessed 21 January 2020.
  15. Cacau LdeAP, Oliveira GU, Maynard LG, Araújo Filho AAde, Silva WMda, Cerqueria Neto ML, Antoniolli AR, Santana-Filho VJ. The use of the virtual reality as intervention tool in the postoperative of cardiac surgery. Rev Bras Cir Cardiovasc 2013;28:281–9.
  16. Carrougher GJ, Hoffman HG, Nakamura D, Lezotte D, Soltani M, Leahy L, Engrav LH, Patterson DR. The effect of virtual reality on pain and range of motion in adults with burn injuries. J Burn Care Res 2009;30:785–91.
  17. Chad R, Emaan S, Jillian O. Effect of virtual reality headset for pediatric fear and pain distraction during immunization. Pain Manag 2018;8:175–9.
  18. Chan E, Foster S, Sambell R, Leong P. Clinical efficacy of virtual reality for acute procedural pain management: a systematic review and meta-analysis. PLoS One 2018;13:e0200987.
  19. Chan E, Hovenden M, Ramage E, Ling N, Pham JH, Rahim A, Lam C, Liu L, Foster S, Sambell R, Jeyachanthiran K, Crock C, Stock A, Hopper SM, Cohen S, Davidson A, Plummer K, Mills E, Craig SS, Deng G, Leong P. Virtual reality for pediatric needle procedural pain: two randomized clinical trials. J Pediatr 2019;209:160–7.e4.
  20. Chan PY, Scharf S. Virtual reality as an adjunctive nonpharmacological sedative during orthopedic surgery under regional anesthesia: a pilot and feasibility study. Anesth Analg 2017;125:1200–2.
  21. Chen CH, Jeng MC, Fung CP, Doong JL, Chuang TY. Psychological benefits of virtual reality for patients in rehabilitation therapy. J Sport Rehabil 2009;18:258–68.
  22. Conley N, Guck AJ, Davis M, Madi D, Nowlin A, Trost Z. Examining the feasibility of a virtual reality graded exposure intervention for pain-related fear and disability in chronic low back pain. World Congress on Pain (October 2014). Buenos Aires, Argentina: International Association for the Study of Pain.
  23. Delshad SD, Almario CV, Fuller G, Luong D, Spiegel BMR. Economic analysis of implementing virtual reality therapy for pain among hospitalized patients. npj Digital Med 2018.
  24. Ding J, He Y, Chen L, Zhu B, Cai Q, Chen K, Liu G. Virtual reality distraction decreases pain during daily dressing changes following haemorrhoid surgery. J Int Med Res 2019;47:4380–8.
  25. Dunn J, Yeo E, Moghaddampour P, Chau B, Humbert S. Virtual and augmented reality in the treatment of phantom limb pain: a literature review. NeuroRehabilitation 2017;40:595–601.
  26. Eijlers R, Dierckx B, Staals LM, Berghmans JM, van der Schroeff MP, Strabbing EM, Wijnen RMH, Hillegers MHJ, Legerstee JS, Utens EMWJ. Virtual reality exposure before elective day care surgery to reduce anxiety and pain in children: a randomised controlled trial. Eur J Anaesthesiol 2019;36:728–37.
  27. Eijlers R, Utens EMWJ, Staals LM, de Nijs PFA, Berghmans JM, Wijnen RMH, Hillegers MHJ, Dierckx B, Legerstee JS. Systematic review and meta-analysis of virtual reality in pediatrics: effects on pain and anxiety. Anesth Analg 2019;129:1344–53.
  28. France CR, Thomas JS. Virtual immersive gaming to optimize recovery (VIGOR) in low back pain: a phase II randomized controlled trial. Contemp Clin Trials 2018;69:83–91.
  29. Freitas DMdeO, Spadoni VS. Is virtual reality useful for pain management in patients who undergo medical procedures? Einstein (Sao Paulo) 2019;17:eMD4837.
  30. Frey DP, Bauer ME, Bell CL, Low LK, Hassett AL, Cassidy RB, Boyer KD, Sharar SR. Virtual reality analgesia in labor: the VRAIL pilot study-A preliminary randomized controlled trial suggesting benefit of immersive virtual reality analgesia in unmedicated laboring women. Anesth Analg 2019;128:e93–6.
  31. Furman E, Jasinevicius TR, Bissada NF, Victoroff KZ, Skillicorn R, Buchner M. Virtual reality distraction for pain control during periodontal scaling and root planing procedures. J Am Dent Assoc 2009;140:1508–16.
  32. Fusaro M, Tieri G, Aglioti SM. Influence of cognitive stance and physical perspective on subjective and autonomic reactivity to observed pain and pleasure: an immersive virtual reality study. Conscious Cogn 2019;67:86–97.
  33. Fusaro M, Tieri G, Aglioti SM. Seeing pain and pleasure on self and others: behavioral and psychophysiological reactivity in immersive virtual reality. J Neurophysiol 2016;116:2656–62.
  34. Garcia-Palacios A, Herrero R, Vizcaíno Y, Belmonte MA, Castilla D, Molinari G, Baños RM, Botella C. Integrating virtual reality with activity management for the treatment of fibromyalgia: acceptability and preliminary efficacy. Clin J Pain 2015;31:564–72.
  35. Garrett B, Taverner T, Gromala D, Tao G, Cordingley E, Sun C. Virtual reality clinical research: promises and challenges. JMIR Serious Games 2018;6:e10839.
  36. Garrett B, Taverner T, Masinde W, Gromala D, Shaw C, Negraeff M. A rapid evidence assessment of immersive virtual reality as an adjunct therapy in acute pain management in clinical practice. Clin J Pain 2014;30:1089–98.
  37. Georgescu R, Fodor LA, Dobrean A, Cristea IA. Psychological interventions using virtual reality for pain associated with medical procedures: a systematic review and meta-analysis. Psychol Med 2020;50:1795–1807.
  38. Gershon J, Zimand E, Pickering M, Rothbaum BO, Hodges L. A pilot and feasibility study of virtual reality as a distraction for children with cancer. J Am Acad Child Adolesc Psychiatry 2004;43:1243–9.
  39. Gonzalez-Franco M, Peck TC. Avatar embodiment. Towards a standardized questionnaire. Front Robot AI 2018;5. doi:10.3389/frobt.2018.00074. [DOI: 10.3389/frobt.2018.00074]
  40. González-Franco M, Peck TC, Rodríguez-Fornells A, Slater M. A threat to a virtual hand elicits motor cortex activation. Exp Brain Res 2014;232:875–87.
  41. Gromala D, Song M, Yim J, Fox T, Barnes SJ, Nazemi M, Shaw C, Squire P, Immersive VR. A Non-Pharmacological Analgesic for Chronic Pain? CHI. Vancouver: 2011:1171–6.
  42. Gutierrez-Maldonado J, Gutierrez-Martinez O, Cabas-Hoyos K. Interactive and passive virtual reality distraction: effects on presence and pain intensity. Stud Health Technol Inform 2011;167:69–73.
  43. Gutiérrez-Martínez O, Gutiérrez-Maldonado J, Loreto-Quijada D. Control over the virtual environment influences the presence and efficacy of a virtual reality intervention on pain. Stud Health Technol Inform 2011;167:111–15.
  44. Harvie DS, Sterling M, Smith AD. Do pain-associated contexts increase pain sensitivity? An investigation using virtual reality. Scand J Pain 2018;18:525–32.
  45. Herrador Colmenero L, Perez Marmol JM, Martí-García C, Querol Zaldivar MdeLÁ, Tapia Haro RM, Castro Sánchez AM, Aguilar-Ferrándiz ME. Effectiveness of mirror therapy, motor imagery, and virtual feedback on phantom limb pain following amputation: a systematic review. Prosthet Orthot Int 2018;42:288–98.
  46. Herrero R, García-Palacios A, Castilla D, Molinari G, Botella C. Virtual reality for the induction of positive emotions in the treatment of fibromyalgia: a pilot study over acceptability, satisfaction, and the effect of virtual reality on mood. Cyberpsychology Behav Soc Netw 2014;17:379–84.
  47. Hoffman HG, Garcia-Palacios A, Patterson DR, Jensen M, Furness T III, Ammons WF Jr. The effectiveness of virtual reality for dental pain control: a case study. Cyberpsychol Behav 2001;4:527–35.
  48. Hoffman HG, Sharar SR, Coda B, Everett JJ, Ciol M, Richards T, Patterson DR. Manipulating presence influences the magnitude of virtual reality analgesia. PAIN 2004;111:162–8.
  49. Honzel E, Murthi S, Brawn-Cinani B, Colloca G, Kier C, Varshney A, Colloca L. Virtual reality, music, and pain: developing the premise for an interdisciplinary approach to pain management. PAIN 2019;160:1909–19.
  50. Rezaei I, Razeghi M, Ebrahimi S, Kayedi S, Rezaeian Zadeh A. A novel virtual reality technique (Cervigame) compared to conventional proprioceptive training to treat neck pain: a randomized controlled trial. J Biomed Phys Eng 2019;9:355–66.
  51. Indovina P, Barone D, Gallo L, Chirico A, De Pietro G, Giordano A. Virtual reality as a distraction intervention to relieve pain and distress during medical procedures: a comprehensive literature review. Clin J Pain 2018;34:858–77.
  52. Jarvis L. Narrative as virtual reality 2: revisiting immersion and interactivity in literature and electronic media. Int J Perform Arts Digit Media 2019;15:239–41.
  53. Jeon B, Cho S, Lee JH. Application of virtual body swapping to patients with complex regional pain syndrome: a pilot study. Cyberpsychology Behav Soc Netw 2014;17:366–70.
  54. Johnson S, Coxon M. Sound can enhance the analgesic effect of virtual reality. R Soc Open Sci 2016;3:150567.
  55. Jones T, Moore T, Choo J. The impact of virtual reality on chronic pain. PLoS One 2016;11:e0167523.
  56. Keefe FJ, Huling DA, Coggins MJ, Keefe DF, Rosenthal MZ, Herr NR, Hoffman HG. Virtual reality for persistent pain: a new direction for behavioral pain management. PAIN 2012;153:2163–6.
  57. Kilteni K, Groten R, Slater M. The sense of embodiment in virtual reality. Presence Teleoperators Virtual Environ 2012;21:373–87.
  58. Kokkinara E, Kilteni K, Blom KJ, Slater M. First person perspective of seated participants over a walking virtual body leads to illusory agency over the walking. Sci Rep 2016;6:28879.
  59. Leibovici V, Magora F, Cohen S, Ingber A. Effects of virtual reality immersion and audiovisual distraction techniques for patients with pruritus. Pain Res Manag 2009;14:283–6.
  60. Li WHC, Chung JOK, Ho EKY. The effectiveness of therapeutic play, using virtual reality computer games, in promoting the psychological well-being of children hospitalised with cancer. J Clin Nurs 2011;20:2135–43.
  61. Lin DH, Lin YF, Chai HM, Han YC, Jan MH. Comparison of proprioceptive functions between computerized proprioception facilitation exercise and closed kinetic chain exercise in patients with knee osteoarthritis. Clin Rheumatol 2007;26:520–8.
  62. Lin HT, Li YI, Hu WP, Huang CC, Du YC. A scoping review of the efficacy of virtual reality and exergaming on patients of musculoskeletal system disorder. J Clin Med 2019;8:791.
  63. Luo H, Cao C, Zhong J, Chen J, Cen Y. Adjunctive virtual reality for procedural pain management of burn patients during dressing change or physical therapy: a systematic review and meta-analysis of randomized controlled trials. Wound Repair Regen 2019;27:90–101.
  64. Mallari B, Spaeth EK, Goh H, Boyd BS. Virtual reality as an analgesic for acute and chronic pain in adults: a systematic review and meta-analysis. J Pain Res 2019;12:2053–85.
  65. Malloy KM, Milling LS. The effectiveness of virtual reality distraction for pain reduction: a systematic review. Clin Psychol Rev 2010;30:1011–8.
  66. Martini M. Real, rubber or virtual: the vision of “one's own” body as a means for pain modulation. A narrative review. Conscious Cogn 2016;43:143–51.
  67. Martini M, Kilteni K, Maselli A, Sanchez-Vives M. The body fades away: investigating the effects of transparency of an embodied virtual body on pain threshold and body ownership. Sci Rep 2015;5:13948.
  68. Martini M, Perez-Marcos D, Sanchez-Vives MV. What color is my arm? Changes in skin color of an embodied virtual arm modulates pain threshold. Front Hum Neurosci 2013;7:438.
  69. Matamala-Gomez M, Donegan T, Bottiroli S, Sandrini G, Sanchez-Vives MV, Tassorelli C. Immersive virtual reality and virtual embodiment for pain relief. Front Hum Neurosci 2019;13:279.
  70. Mcmahan A. Immersion, engagement and presence: a method for analyzing 3-D video games. In: Video Game Theory Reader. New York: Routledge, 2003. p. 67–86. Available: https://alisonmcmahan.com/node/277 . Accessed January 21, 2020.
  71. Morris LD, Louw QA, Grimmer KA, Meintjes E. Targeting pain catastrophization in patients with fibromyalgia using virtual reality exposure therapy: a proof-of-concept study. J Phys Ther Sci 2015;27:3461–7.
  72. Mosso JL, Gorini A, De La Cerda G, Obrador T, Almazan A, Mosso D, Nieto JJ, Riva G. Virtual reality on mobile phones to reduce anxiety in outpatient surgery. Stud Health Technol Inform 2009;142:195–200.
  73. Mühlberger A, Wieser MJ, Kenntner-Mabiala R, Pauli P, Wiederhold BK. Pain modulation during drives through cold and hot virtual environments. Cyberpsychol Behav 2007;10:516–22.
  74. Mütterlein J. The three pillars of virtual reality? Investigating the roles of immersion, presence, and interactivity. 2018. doi:10.24251/HICSS.2018.174.
  75. Nierula B, Martini M, Matamala-Gomez M, Slater M, Sanchez-Vives MV. Seeing an embodied virtual hand is analgesic contingent on colocation. J Pain 2017;18:645–55.
  76. Nilsson S, Finnstrom B, Kokinsky E, Enskar K. The use of Virtual Reality for needle-related procedural pain and distress in children and adolescents in a paediatric oncology unit. Eur J Oncol Nurs 2009;13:102–9.
  77. Nowlin L, Madi D, Guck AJ, Davis M, Trost Z. Examining virtual reality gaming for pain-related fear and disability in chronic low back pain. Soc Behav Med.
  78. Penn T, Browning W, France C, Hardee G, Zielke M, Trost Z. Attitudes toward a virtual reality physical activity intervention among veterans with chronic low back pain. J Pain 2017;18:S1.
  79. Powell W, Simmonds MJ. Virtual reality and musculoskeletal pain: manipulating sensory cues to improve motor performance during walking. Cyberpsychology Behav Soc Netw 2014;17:390–6.
  80. Riva G, Mantovani F, Capideville CS, Preziosa A, Morganti F, Villani D, Gaggioli A, Botella C, Alcañiz M. Affective interactions using virtual reality: the link between presence and emotions. Cyberpsychology Behav Impact Internet Multimed Virtual Real Behav Soc 2007;10:45–56.
  81. Riva G, Wiederhold BK, Mantovani F. Neuroscience of virtual reality: from virtual exposure to embodied medicine. Cyberpsychology Behav Soc Netw 2019;22:82–96.
  82. Romano D, Llobera J, Blanke O. Size and viewpoint of an embodied virtual body affect the processing of painful stimuli. J Pain 2016;17:350–8.
  83. Rothgangel A, Braun S, Winkens B, Beurskens A, Smeets R. Traditional and augmented reality mirror therapy for patients with chronic phantom limb pain (PACT study): results of a three-group, multicentre single-blind randomized controlled trial. Clin Rehabil 2018;32:1591–608.
  84. Sarig Bahat H, Takasaki H, Chen X, Bet-Or Y, Treleaven J. Cervical kinematic training with and without interactive VR training for chronic neck pain—a randomized clinical trial. Man Ther 2015;20:68–78.
  85. Sarig-Bahat H, Weiss PLT, Laufer Y. Neck pain assessment in a virtual environment. Spine 2010;35:E105–112.
  86. Sato K, Fukumori S, Matsusaki T, Maruo T, Ishikawa S, Nishie H, Takata K, Mizuhara H, Mizobuchi S, Nakatsuka H, Matsumi M, Gofuku A, Yokoyama M, Morita K. Nonimmersive virtual reality mirror visual feedback therapy and its application for the treatment of complex regional pain syndrome: an open-label pilot study. Pain Med 2010;11:622–9.
  87. Scapin S, Echevarría-Guanilo ME, Boeira Fuculo Junior PR, Gonçalves N, Rocha PK, Coimbra R. Virtual Reality in the treatment of burn patients: a systematic review. Burns 2018;44:1403–16.
  88. Sharar SR, Alamdari A, Hoffer C, Hoffman HG, Jensen MP, Patterson DR. Circumplex model of affect: a measure of pleasure and arousal during virtual reality distraction analgesia. Games Health J 2016;5:197–202.
  89. Shiri S, Feintuch U, Weiss N, Pustilnik A, Geffen T, Kay B, Meiner Z, Berger I. A virtual reality system combined with biofeedback for treating pediatric chronic headache–a pilot study. Pain Med 2013;14:621–7.
  90. Sil S, Dahlquist LM, Thompson C, Hahn A, Herbert L, Wohlheiter K, Horn S. The effects of coping style on virtual reality enhanced videogame distraction in children undergoing cold pressor pain. J Behav Med 2014;37:156–65.
  91. Smith A, Carlow K, Biddulph T, Murray B, Paton M, Harvie DS. Contextual modulation of pain sensitivity utilising virtual environments. Br J Pain 2017;11:71–80.
  92. Solcà M, Ronchi R, Bello-Ruiz J, Schmidlin T, Herbelin B, Luthi F, Konzelmann M, Beaulieu J-Y, Delaquaize F, Schnider A, Guggisberg AG, Serino A, Blanke O. Heartbeat-enhanced immersive virtual reality to treat complex regional pain syndrome. Neurology 2018;91:e479–89.
  93. Tanja-Dijkstra K, Pahl S, White MP, Andrade J, Qian C, Bruce M, May J, Moles DR. Improving dental experiences by using virtual reality distraction: a simulation study. PLoS One 2014;9:e91276.
  94. Thompson T, Steffert T, Steed A, Gruzelier J. A randomized controlled trial of the effects of hypnosis with 3-D virtual reality animation on tiredness, mood, and salivary cortisol. Int J Clin Exp Hypn 2011;59:122–42.
  95. de Tommaso M, Ricci K, Laneve L, Savino N, Antonaci V, Livrea P. Virtual visual effect of hospital waiting room on pain modulation in healthy subjects and patients with chronic migraine. Pain Res Treat 2013;2013:515730.
  96. Trost Z, Jones A, Guck A, Vervoort T, Kowalsky JM, France CR. Initial validation of a virtual blood draw exposure paradigm for fear of blood and needles. J Anxiety Disord 2017;51:65–71.
  97. Trost Z, Nowlin L, Guck A, Madi D, Davis M. Exploring the role of pain-related fear and catastrophizing in response to a virtual reality gaming intervention for chronic low back pain. J Pain 2015;16:S98.
  98. Wender R, Hoffman HG, Hunner HH, Seibel EJ, Patterson DR, Sharar SR. Interactivity influences the magnitude of virtual reality analgesia. J Cyber Ther Rehabil 2009;2:27–33.
  99. Wiederhold MD, Gao K, Wiederhold BK. Clinical use of virtual reality distraction system to reduce anxiety and pain in dental procedures. Cyberpsychology Behav Soc Netw 2014;17:359–65.
  100. Williams ACdeC, Craig KD. Updating the definition of pain. PAIN 2016;157:2420–3.
  101. Witmer BG, Singer MJ. Measuring presence in virtual environments: a presence questionnaire. Presence Teleoperators Virtual Environ 1998;7:225–40.
  102. Wittkopf PG, Johnson MI. Managing pain by visually distorting the size of painful body parts: is there any therapeutic value? Pain Manag 2016;6:201–4.
  103. Wittkopf PG, Lloyd DM, Coe O, Yacoobali S, Billington J. The effect of interactive virtual reality on pain perception: a systematic review of clinical studies. Disabil Rehabil 2019;8:1–12.
  104. Won AS, Bailey J, Bailenson J, Tataru C, Yoon IA, Golianu B. Immersive virtual reality for pediatric pain. Child Basel Switz 2017;4.
  105. Yilmaz Yelvar GD, Çirak Y, Dalkilinç M, Parlak Demir Y, Guner Z, Boydak A. Is physiotherapy integrated virtual walking effective on pain, function, and kinesiophobia in patients with non-specific low-back pain? Randomised controlled trial. Eur Spine J 2017;26:538–45.
  106. Zeroth JA, Dahlquist LM, Foxen-Craft EC. The effects of auditory background noise and virtual reality technology on video game distraction analgesia. Scand J Pain 2019;19:207–17.

MeSH Term

Humans
Pain
Pain Management
Virtual Reality

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