Jidan Liu: School of Chemistry and Chemical Engineering, Institute of Clean Energy and Materials, Guangzhou Key Laboratory for Clean Energy and Materials, Guangzhou University, Guangzhou 510006, P. R. China. ORCID
Zhenke Yang: School of Chemistry and Chemical Engineering, Institute of Clean Energy and Materials, Guangzhou Key Laboratory for Clean Energy and Materials, Guangzhou University, Guangzhou 510006, P. R. China.
Jinyuan Jiang: School of Chemistry and Chemical Engineering, Institute of Clean Energy and Materials, Guangzhou Key Laboratory for Clean Energy and Materials, Guangzhou University, Guangzhou 510006, P. R. China.
Qiaohai Zeng: School of Chemistry and Chemical Engineering, Institute of Clean Energy and Materials, Guangzhou Key Laboratory for Clean Energy and Materials, Guangzhou University, Guangzhou 510006, P. R. China.
Liyao Zheng: School of Chemistry and Chemical Engineering, Institute of Clean Energy and Materials, Guangzhou Key Laboratory for Clean Energy and Materials, Guangzhou University, Guangzhou 510006, P. R. China. ORCID
Zhao-Qing Liu: School of Chemistry and Chemical Engineering, Institute of Clean Energy and Materials, Guangzhou Key Laboratory for Clean Energy and Materials, Guangzhou University, Guangzhou 510006, P. R. China. ORCID
The synthesis of C3-substituted isoindolin-1-ones from oxazolines and Cyclopropanols has been achieved with oxazoline as a bifunctional nucleophilic directing group. The reaction proceeds by the cleavage of three chemical bonds and allows the formation of three new chemical bonds, a C-N bond, a C-C bond, and a C-O bond, in a single step.
