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Journal of autism and developmental disorders
Jul, 2022;52 (7): 3076-3087.

The Importance of Understanding Individual Differences of Emotion Regulation Abilities in 22q11.2 Deletion Syndrome.

L E Campbell, L Swaab, E E Freeman, L McCormack, T J Simon, K Angkustsiri, K L McCabe
Author Information
  1. L E Campbell: School of Psychological Science, University of Newcastle, Newcastle, Australia. linda.e.campbell@newcastle.edu.au. ORCID
  2. L Swaab: School of Psychological Science, University of Newcastle, Newcastle, Australia.
  3. E E Freeman: School of Psychological Science, University of Newcastle, Newcastle, Australia.
  4. L McCormack: School of Psychological Science, University of Newcastle, Newcastle, Australia.
  5. T J Simon: Department of Psychiatry and Behavioural Sciences, University of California Davis, 2825 50th Street, Sacramento, CA, 95817, USA.
  6. K Angkustsiri: M.I.N.D. Institute, University of California Davis, 2825 50th Street, Sacramento, CA, 95817, USA.
  7. K L McCabe: Department of Psychiatry and Behavioural Sciences, University of California Davis, 2825 50th Street, Sacramento, CA, 95817, USA.
PMID: 34251567 DOI: 10.1007/s10803-021-05172-9

Abstract

Chromosome 22q11.2 deletion syndrome (22q11DS) is characterised by a complex behavioural phenotype including anxiety, attention-deficit/hyperactivity disorder and psychosis. In the current study, we aimed at improving our understanding of the heterogeneity of behavioural characteristics in a group of 129 young people (aged 4-22) with a confirmed 22q11.2 microdeletion and 116 age and gender matched typically developing controls. Half the participants with 22q11DS had behaviour characterised by emotion dysregulation. A cluster analyses, of the participants with 22q11DS, revealed four groups characterised by intact emotion regulation; predominantly internalizing problems; both internalizing and externalizing problems; and predominantly externalizing difficulties. Importantly, it was found that young people with 22q11DS whose emotion dysregulation was characterised by externalizing problems had the poorest levels of functioning. As our understanding of 22q11DS improves, it is becoming increasingly clear that we need a better understanding of how individual differences and psychosocial factors contribute to, and interact with one another, to result in the observable individual differences in the 22q11DS behavioural phenotype.

Keywords

22q11DS Attention-deficit/hyperactivity disorder Emotion regulation Externalizing disorder Velo-cardio-facial syndrome

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Grants

  1. R01HD042974/NIH HHS
  2. R01HD042974/NIH HHS

MeSH Term

Adolescent
Attention Deficit Disorder with Hyperactivity
Autism Spectrum Disorder
DiGeorge Syndrome
Emotional Regulation
Humans
Individuality
Journal Article
Article has an altmetric score of 2

Word Cloud

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