Distribution and volume analysis of early hemorrhagic contusions by MRI after traumatic brain injury: a preliminary report of the Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx).
Marianna La Rocca, Giuseppe Barisano, Alexis Bennett, Rachael Garner, Jerome Engel, Emily J Gilmore, David L McArthur, Eric Rosenthal, James Stanis, Paul Vespa, Frederick Willyerd, Lara L Zimmermann, Arthur W Toga, Dominique Duncan, EpiBioS4Rx Study Group
Author Information
Marianna La Rocca: Laboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA. marianna.larocca@loni.usc.edu. ORCID
Giuseppe Barisano: Laboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.
Alexis Bennett: Laboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.
Rachael Garner: Laboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.
Jerome Engel: David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Emily J Gilmore: Comprehensive Epilepsy Center, Department of Neurology, Yale University, New Haven, CT, USA.
David L McArthur: David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Eric Rosenthal: Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
James Stanis: Laboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.
Paul Vespa: David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Frederick Willyerd: Phoenix Children's Hospital, Phoenix, AZ, USA.
Lara L Zimmermann: University of California Davis Medical Center, Sacramento, CA, USA.
Arthur W Toga: Laboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.
Dominique Duncan: Laboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.
Traumatic brain injury (TBI) can produce heterogeneous injury patterns including a variety of hemorrhagic and non-hemorrhagic lesions. The impact of lesion size, location, and interaction between total number and location of contusions may influence the occurrence of seizures after TBI. We report our methodologic approach to this question in this preliminary report of the Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx). We describe lesion identification and segmentation of hemorrhagic contusions by early posttraumatic magnetic resonance imaging (MRI). We describe the preliminary methods of manual lesion segmentation in an initial cohort of 32 TBI patients from the EpiBioS4Rx cohort and the preliminary association of hemorrhagic contusion and edema location and volume to seizure incidence.
