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2022;23 (1): 1-16.

Self-assisted wound healing using piezoelectric and triboelectric nanogenerators.

Fu-Cheng Kao, Hsin-Hsuan Ho, Ping-Yeh Chiu, Ming-Kai Hsieh, Jen-Chung Liao, Po-Liang Lai, Yu-Fen Huang, Min-Yan Dong, Tsung-Ting Tsai, Zong-Hong Lin
Author Information
  1. Fu-Cheng Kao: Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan.
  2. Hsin-Hsuan Ho: Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan.
  3. Ping-Yeh Chiu: Department of Orthopaedic Surgery, Spine Section, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
  4. Ming-Kai Hsieh: Department of Orthopaedic Surgery, Spine Section, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
  5. Jen-Chung Liao: Department of Orthopaedic Surgery, Spine Section, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
  6. Po-Liang Lai: Department of Orthopaedic Surgery, Spine Section, Chang Gung Memorial Hospital, Taoyuan, Taiwan. ORCID
  7. Yu-Fen Huang: Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan.
  8. Min-Yan Dong: Material and Chemical Research Laboratories, Industrial Technology Research Institute, Hsinchu, Taiwan.
  9. Tsung-Ting Tsai: Department of Orthopaedic Surgery, Spine Section, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
  10. Zong-Hong Lin: Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan. ORCID
PMID: 35023999 DOI: 10.1080/14686996.2021.2015249

Abstract

The complex process of wound healing depends on the coordinated interaction between various immunological and biological systems, which can be aided by technology. This present review provides a broad overview of the medical applications of piezoelectric and triboelectric nanogenerators, focusing on their role in the development of wound healing technology. Based on the finding that the damaged epithelial layer of the wound generates an endogenous bioelectric field to regulate the wound healing process, development of technological device for providing an exogenous electric field has therefore been paid attention. Authors of this review focus on the design and application of piezoelectric and triboelectric materials to manufacture self-powered nanogenerators, and conclude with an outlook on the current challenges and future potential in meeting medical needs and commercialization.

Keywords

201 Electronics / Semiconductor / TCOs < 200 Applications, 202 Dielectrics / Piezoelectrics / Insulators < 200 Applications, 211 Scaffold / Tissue engineering/Drug delivery < 200 Applications, 212 Surface and interfaces < 200 Applications Wound healing nanogenerator piezoelectric effect self-powered system triboelectric effect

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