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Current opinion in chemical biology
04, 2022;67 102115.

Super-multiplexed vibrational probes: Being colorful makes a difference.

Naixin Qian, Wei Min
Author Information
  1. Naixin Qian: Department of Chemistry, Columbia University, New York, NY, 10027, USA.
  2. Wei Min: Department of Chemistry, Columbia University, New York, NY, 10027, USA. Electronic address: wm2256@columbia.edu.
PMID: 35077919 DOI: 10.1016/j.cbpa.2021.102115

Abstract

Biological systems with intrinsic complexity require multiplexing techniques to comprehensively describe the phenotype, interaction, and heterogeneity. Recent years have witnessed the development of super-multiplexed vibrational microscopy, overcoming the 'color barrier' of fluorescence-based optical techniques. Here, we will review the recent progress in the design and applications of super-multiplexed vibrational probes. We hope to illustrate how rainbow-like vibrational colors can be generated from systematic studies on structure-spectroscopy relationships and how being colorful makes a difference to various biomedical applications.

Keywords

Multiplex imaging Raman microscopy Stimulated Raman scattering Vibrational probes

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Grants

  1. R01 EB029523/NIBIB NIH HHS
  2. R01 GM128214/NIGMS NIH HHS
  3. R01 GM132860/NIGMS NIH HHS

MeSH Term

Microscopy
Spectrum Analysis, Raman
Vibration
Journal Article Research Support, N.I.H., Extramural Review

Word Cloud

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