Information regarding the prevalence of plagiarism and its contributing factors are limited in Myanmar. We aimed to explore the knowledge, attitudes, and self-reported plagiarism practices of postgraduate students in Myanmar's universities and determine the factors associated with plagiarism. We conducted a cross-sectional questionnaire study during 2019-2020. The questionnaire contained: 1) demographics, 2) knowledge on plagiarism, 3) attitudes toward plagiarism, and 4) self-reported plagiarism practices. We calculated attitudes and plagiarism severity scores (PSS). We conducted multiple linear regression analyses and binary logistic regression analyses. A p-value <0.05 denoted statistical significance. We enrolled 217 participants. Of our participants, 37.6% self-reported at least one plagiarism act. The mean attitude score (S.D.) was 62.24 (10.44), (maximum score was 92, higher scores represent disapproval of plagiarism). This attitude score reflects only a moderate attitude toward disapproval of plagiarism. The attitude score was significantly higher for doctoral students (9.2%) than master students (90.8%); p = 0.003; and for participants with publications (13.4%) compared with those without publications (86.6%); p = 0.005. The attitude score was a significant predictor of the PSS. We conclude that there is evidence to suggest that plagiarism represents a significant ethical issue in Myanmar and recommend that Myanmar universities provide training in responsible conduct of research.