The pandemic of Covid-19, an epidemic outbreak created many challenges and increased the demand for medical equipments, medicines, and related accessories and most of them had to be imported from abroad. The advanced information technology (Industry 4.0) was considered imperative to track and monitor the spread of the SARS-2 Virus that is Covid-19. A detailed review of literature is done to understand the challenges and the remedial action taken so far during the Covid-19 epidemic outbreak had been gone through using appropriate search engines and databases like Google-search, Science Direct, Scopus, Research Gate, and relevant blogs. The case reports were also considered in this study. We have found ten significant challenges (barriers) and identified several useful technology of industry 4.0 to control and manage the Covid-19 pandemic. This research paper is an attempt to examine and discuss the application of 4.0 technologies in containing the pandemic outbreak. Ten challenges were identified and those could be overcome by promptly applying appropriate technologies of industry 4.0 to control the spread of virus. These technologies help to educate and communicate the public and make them aware of the hazardous attack of Covid-19 virus when properly used.
