Omicron: a shift in the biology of SARS-CoV-2.

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Abstract

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References

  1. Viana, R. et al. Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa. Nature 603, 679–686 (2022). A review article that summarizes the emergence of the Omicron variant in South Africa. [DOI: 10.1038/s41586-022-04411-y]
  2. Peacock, T. P. et al. The altered entry pathway and antigenic distance of the SARS-CoV-2 Omicron variant map to separate domains of spike protein. Preprint at bioRxiv https://doi.org/10.1101/2021.12.31.474653 (2022). This paper reports a change in cell tropism and in the cell entry pathway of the Omicron variant.
  3. Meng, B. et al. Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity. Nature 603, 706–714 (2022). This paper also reports a change in cell tropism and in the cell entry pathway of the Omicron variant. [DOI: 10.1038/s41586-022-04474-x]
  4. Pascall, D. J. et al. The SARS-CoV-2 Alpha variant caused increased clinical severity of disease in Scotland: a genomics-based prospective cohort analysis. Preprint at medRxiv https://doi.org/10.1101/2021.08.17.21260128 (2022). A review article that presents evidence of considerable heterogeneity in clinical severity associated with different variants.

MeSH Term

Biology
COVID-19
Cell Line
Humans
SARS-CoV-2

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