Epidemiological Study of Neonatal Congenital Microtia in Shandong Province, China, 2011-2020.

Pengfei Sun, Qian Lin, Min Zhang, Zhenzhong Liu, Lingdong Zhu
Author Information
  1. Pengfei Sun: Department of Plastic Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing.
  2. Qian Lin: Department of Child Health, Jinan Maternity and Child Care Hospital.
  3. Min Zhang: Department of Child Health, Jinan Maternity and Child Care Hospital.
  4. Zhenzhong Liu: Department of Plastic and Burn Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University.
  5. Lingdong Zhu: Department of Plastic Surgery, Children's Hospital Affiliated to Shandong University; Jinan Children's Hospital, Jinan, Shandong Province, China.

Abstract

OBJECTIVE: congenital microtia is a common congenital disease in newborns. The specific cause of congenital microtia is currently unknown. The main objective of this study is to elucidate the epidemiological characteristics of congenital microtia and explore the possible etiology of congenital microtia.
METHODS: Part of the newborn data from 2011 to 2020 in Shandong Province Birth Defects Monitoring Hospitals were randomly selected. The software GraphPad Prism 9 was used to analyze the data and draw figures.
RESULTS: A total of 4247 infants were diagnosed with congenital malformation among 149,525 newborns randomly selected from the Shandong Province Birth Defects Monitoring Hospitals. Among them, a total of 115 infants were diagnosed with congenital microtia. The mean incidence of microtia during 10 years was 76.14±21.93 per 100,000 infants. The mean incidence of microtia in infants with congenital malformation was 2.67±0.75%. The average incidence of male and female infants with microtia during 10 years were 86.93±23.22 and 64.18±32.71 per 100,000 infants, respectively. In terms of maternal age, the older the mother, the higher the incidence of microtia. In terms of the place of residence, rural infants have a higher incidence of microtia than urban infants.
CONCLUSIONS: The average incidence of microtia was 76.14±21.93 per 100,000 infants in Shandong Province, China, 2011-2020. The female-to-male incidence ratio was 1.45:1. The authors recommend that women choose to give birth at the age of 25 to 29. They hope that the government will take measures to improve the medical and health conditions in rural areas and improve parenting knowledge in rural areas. This can effectively reduce the prevalence of microtia in infants.

References

  1. Paul A, Achard S, Simon F, et al. Congenital abnormalities associated with microtia: a 10-year retrospective study. Int J Pediatr Otorhinolaryngol. 2021;146:110764.
  2. Bhatti SL, Daly LT, Mejia M, et al. Ear abnormalities. Pediatr Rev. 2021;42:180–188.
  3. Hartzell LD, Chinnadurai S. Microtia and related facial anomalies. Clin Perinatol. 2018;45:679–697.
  4. Guo R, Wang B, Wang Y, et al. Epidemiological analysis and the nomogram for possible risk factors for severe microtia. J Craniofac Surg. 2021;32:e184–e189.
  5. Luquetti DV, Heike CL, Hing AV, et al. Microtia: epidemiology and genetics. Am J Med Genet A. 2012;158A:124–139.
  6. Umbaugh HM, Crerand CE, Stock NM, et al. Microtia and craniofacial microsomia: content analysis of facebook groups. Int J Pediatr Otorhinolaryngol. 2020;138:110301.
  7. Nuyen BA, Kandathil CK, Saltychev M, et al. The social perception of microtia and auricular reconstruction. Laryngoscope. 2021;131:195–200.
  8. Deng K, Dai L, Yi L, et al. Epidemiologic characteristics and time trend in the prevalence of anotia and microtia in China. Birth Defects Res A Clin Mol Teratol. 2016;106:88–94.
  9. Luquetti DV, Leoncini E, Mastroiacovo P. Microtia-anotia: a global review of prevalence rates. Birth Defects Res A Clin Mol Teratol. 2011;91:813–822.
  10. Cheng YF, Xirasagar S, Liu TC, et al. Ten-year trends in the incidence of microtia: a nationwide population-based study from Taiwan. Eur Arch Otorhinolaryngol. 2021;278:4315–4319.

MeSH Term

Infant
Female
Infant, Newborn
Male
Humans
Congenital Microtia
China
Maternal Age
Incidence
Prevalence
Epidemiologic Studies
Congenital Abnormalities

Word Cloud

Created with Highcharts 10.0.0microtiainfantscongenitalincidenceShandongProvinceper100000ruralCongenitalnewbornsdataBirthDefectsMonitoringHospitalsrandomlyselectedtotaldiagnosedmalformationmean10years7614±2193averagetermsagehigherChina2011-2020improveareasOBJECTIVE:commondiseasespecificcausecurrentlyunknownmainobjectivestudyelucidateepidemiologicalcharacteristicsexplorepossibleetiologyMETHODS:Partnewborn20112020softwareGraphPadPrism9usedanalyzedrawfiguresRESULTS:4247among149525Among115267±075%malefemale8693±23226418±3271respectivelymaternaloldermotherplaceresidenceurbanCONCLUSIONS:female-to-maleratio145:1authorsrecommendwomenchoosegivebirth2529hopegovernmentwilltakemeasuresmedicalhealthconditionsparentingknowledgecaneffectivelyreduceprevalenceEpidemiologicalStudyNeonatalMicrotia

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