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Current opinion in infectious diseases
10 01, 2022;35 (5): 404-409.

Update on pathogenesis, management, and control of Plasmodium vivax.

Nazia Khan, Johanna P Daily
Author Information
  1. Nazia Khan: Department of Medicine (Infectious Diseases), Albert Einstein College of Medicine, Bronx, New York, USA.
PMID: 36066361 DOI: 10.1097/QCO.0000000000000867

Abstract

PURPOSE OF REVIEW: This is a review of Plasmodium vivax epidemiology, pathogenesis, disease presentation, treatment and innovations in control and elimination. Here, we examine the recent literature and summarize new advances and ongoing challenges in the management of P. vivax .
RECENT FINDINGS: P. vivax has a complex life cycle in the human host which impacts disease severity and treatment regimens. There is increasing data for the presence of cryptic reservoirs in the spleen and bone marrow which may contribute to chronic vivax infections and possibly disease severity. Methods to map the geospatial epidemiology of P. vivax chloroquine resistance are advancing, and they will inform local treatment guidelines. P. vivax treatment requires an 8-aminoquinoline to eradicate the dormant liver stage. Evidence suggests that higher doses of 8-aminoquinolines may be needed for radical cure of tropical frequent-relapsing strains.
SUMMARY: P. vivax is a significant global health problem. There have been recent developments in understanding the complexity of P. vivax biology and optimization of antimalarial therapy. Studies toward the development of best practices for P. vivax control and elimination programs are ongoing.

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Grants

  1. R01 AI164864/NIAID NIH HHS
  2. R21 AI141367/NIAID NIH HHS
  3. R21 AI162007/NIAID NIH HHS

MeSH Term

Antimalarials
Chloroquine
Global Health
Humans
Malaria, Vivax
Plasmodium vivax

Chemicals

Antimalarials
Chloroquine
Journal Article Review Research Support, N.I.H., Extramural
Article has an altmetric score of 1

Word Cloud

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