Obesity is associated with IL-6 gene polymorphisms rs1800795 and rs1800796 but not SOCS3 rs4969170.

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Gulsah Koc, Tansu Doran, Meliha Melin Uygur, Deniz Kirac

Author Information

Gulsah Koc: Department of Medical Biology, Faculty of Medicine, Istanbul Aydin University, Istanbul, Turkey. gulsahkoc@aydin.edu.tr. ORCID
Tansu Doran: Department of Medical Biology, Faculty of Medicine, Yeditepe University, Istanbul, Turkey. ORCID
Meliha Melin Uygur: Department of Endocrinology and Metabolism Disease, Marmara University Pendik Training and Research Hospital, Istanbul, Turkey. ORCID
Deniz Kirac: Department of Medical Biology, Faculty of Medicine, Yeditepe University, Istanbul, Turkey. ORCID

PMID: 36538174 DOI: 10.1007/s11033-022-08129-y

BACKGROUND: An imbalance of inflammatory factors can stimulate obesity by inducing chronic inflammation in adipose tissue. Interleukin-6 (IL-6) is a cytokine with both inflammatory and anti-inflammatory functions. Suppressor of cytokine signaling 3 (SOCS3) acts as an inhibitor for a number of cytokine signals. The IL-6 and SOCS3 genes are known to be involved in lipid and energy metabolism, although it is unclear how these genes relate to obesity. The aim of this study is to determine whether the obesity risk is associated with the IL-6 (rs1800795, rs1800796) and SOCS3 (rs4969170) gene polymorphisms.
METHODS AND RESULTS: Based on their body mass index (BMI) scores, 185 people were determined, of whom 90 were from the control group and 95 were obese. Anthropometric measurements and biochemical parameters of the study subjects were documented during the examination. Genomic DNA isolation was performed from the blood samples of all participants. IL-6 (rs1800795, rs1800796) and SOCS3 (rs4969170) polymorphisms were detected by real-time quantitative polymerase chain reaction (qRT-PCR) from genomic DNA samples. The IL-6 rs1800795 and rs1800796 variants showed a significant difference between the control and obese groups (p = 0.027; p = 0.013). The SOCS3 rs4969170 variation did not substantially differ between the control and obese groups (p = 0.825).
CONCLUSION: In our study, IL-6 rs1800795(G/C) and rs1800796(G/C) polymorphisms appeared to be a risk factor for obesity. The C allele was associated with the obesity phenotypes. However, the SOCS3 rs4969170 (A/G) polymorphism was not linked to an increased risk of obesity. IL-6 polymorphisms may be new targets for obesity treatment.

IL-6 Obesity Polymorphism SOCS3

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2021/8 18635/Research Foundation of Istanbul Aydin University, Turkey

Humans

Cytokines

DNA

Genetic Predisposition to Disease

Genotype

Interleukin-6

Obesity

Polymorphism, Single Nucleotide

Suppressor of Cytokine Signaling Proteins

Cytokines

DNA

Interleukin-6

Suppressor of Cytokine Signaling Proteins

IL6 protein, human

SOCS3 protein, human

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