NIR as a "trigger switch" for situ distinguish superbacteria and photothermal synergistic antibacterial treatment with AgO particles/lignosulfonate/cationic guar gum hybrid hydrogel.
Xianghong Xie: College of Food Science and Engineering, Northwest A&F University, Yangling 712100, Shaanxi, China.
Mingyu Zhang: College of Food Science and Engineering, Northwest A&F University, Yangling 712100, Shaanxi, China.
Ying Li: College of Food Science and Engineering, Northwest A&F University, Yangling 712100, Shaanxi, China.
Yulu Lei: College of Food Science and Engineering, Northwest A&F University, Yangling 712100, Shaanxi, China.
Jing Sun: Qinghai Provincial Key Laboratory of Qinghai-Tibet Plateau Biological Resources, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, Qinghai, China.
Nosirjon Sattorov: Institute of Problems of Biological Safety and Biotechnology, Tajik Academy of Agricultural Sciences, Dushanbe, Tajikistan.
Kamoljon Burkhonovich Makhmudov: Institute of Problems of Biological Safety and Biotechnology, Tajik Academy of Agricultural Sciences, Dushanbe, Tajikistan.
Jianlong Wang: College of Food Science and Engineering, Northwest A&F University, Yangling 712100, Shaanxi, China. Electronic address: wanglong79@nwsuaf.edu.cn.
The in situ identification of superbugs with the simultaneous killing of it is key to preventing human health. Here, a one-stop identification and killing platform for near-infrared (NIR) triggering was designed and constructed using lignosulfonate (LS), cationic guar gum (CG) and AgO NPs hydrogels (LS/CG/AgO). The hydrogel network is used as a fixed matrix for AgO NPs and a nano reactor, meanwhile 3,3', 5,5'-tetramethylbenzidine (TMB) as a single probe sensor array for bacterial identification. In contrast to conventional methods, hybrid hydrogels have catalytic qualities through which TMB be catalyzed to generate oxidized TMB (oxTMB). The drug resistance of the same strain can be distinguished based on the different inhibition abilities of drug-resistant superbacteria in TMB and hydrogel reactions. Then, the employing of oxTMB photothermal characteristics, it can be efficiently killed in real time while being driven by a near-infrared laser. The proposed one-stop hydrogel platform paves a way for the rapid identification and killing of drug-resistant superbacteria.
