Sarah Méresse: Immunologie et Neurogénétique Expérimentales et Moléculaires (INEM), UMR CNRS 7355, Université d'Orléans, 45071 Orléans, France. ORCID
Hélène Gateau: Biologie des Organismes, Stress, Santé, Environnement (BiOSSE), Le Mans Université, Avenue Olivier Messiaen, 72085 Le Mans, France.
Tessa Tirnan: Immunologie et Neurogénétique Expérimentales et Moléculaires (INEM), UMR CNRS 7355, Université d'Orléans, 45071 Orléans, France.
Vanessa Larrigaldie: Immunologie et Neurogénétique Expérimentales et Moléculaires (INEM), UMR CNRS 7355, Université d'Orléans, 45071 Orléans, France.
Nathalie Casse: Biologie des Organismes, Stress, Santé, Environnement (BiOSSE), Le Mans Université, Avenue Olivier Messiaen, 72085 Le Mans, France.
Pamela Pasetto: Institut des Molécules et Matériaux du Mans, UMR CNRS 6283, Le Mans Université, Avenue Olivier Messiaen, 72085 Le Mans, France. ORCID
Jean-Luc Mouget: Biologie des Organismes, Stress, Santé, Environnement (BiOSSE), Le Mans Université, Avenue Olivier Messiaen, 72085 Le Mans, France.
Stéphane Mortaud: Immunologie et Neurogénétique Expérimentales et Moléculaires (INEM), UMR CNRS 7355, Université d'Orléans, 45071 Orléans, France. ORCID
Mostefa Fodil: Biologie des Organismes, Stress, Santé, Environnement (BiOSSE), Le Mans Université, Avenue Olivier Messiaen, 72085 Le Mans, France. ORCID
, a cosmopolitan marine pennate diatom, produces a characteristic blue pigment called marennine that causes the greening of filter-feeding organisms, such as oysters. Previous studies evidenced various biological activities of purified marennine extract, such as antibacterial, antioxidant and antiproliferative effects. These effects could be beneficial to human health. However, the specific biological activity of marennine remains to be characterized, especially regarding primary cultures of mammals. In the present study, we aimed to determine in vitro the effects of a purified extract of marennine on neuroinflammatory and cell migratory processes. These effects were assessed at non-cytotoxic concentrations of 10 and 50μg/mL on primary cultures of neuroglial cells. Marennine strongly interacts with neuroinflammatory processes in the immunocompetent cells of the central nervous system, represented by astrocytes and microglial cells. An anti-migratory activity based on a neurospheres migration assay has also been observed. These results encourage further study of blue pigment effects, particularly the identification of molecular and cellular targets affected by marennine, and strengthen previous studies suggesting that marennine has bioactivities which could be beneficial for human health applications.
