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Progress in the chemistry of organic natural products
2023;122 163-219.

Quality Consistency of Herbal Products: Chemical Evaluation.

Ahmed Osman, Amar G Chittiboyina, Bharathi Avula, Zulfiqar Ali, Sebastian J Adams, Ikhlas A Khan
Author Information
  1. Ahmed Osman: School of Pharmacy, National Center for Natural Products Research, The University of Mississippi, University, MS, 38677, USA. amgalalv@olemiss.edu.
  2. Amar G Chittiboyina: School of Pharmacy, National Center for Natural Products Research, The University of Mississippi, University, MS, 38677, USA.
  3. Bharathi Avula: School of Pharmacy, National Center for Natural Products Research, The University of Mississippi, University, MS, 38677, USA.
  4. Zulfiqar Ali: School of Pharmacy, National Center for Natural Products Research, The University of Mississippi, University, MS, 38677, USA.
  5. Sebastian J Adams: School of Pharmacy, National Center for Natural Products Research, The University of Mississippi, University, MS, 38677, USA.
  6. Ikhlas A Khan: School of Pharmacy, National Center for Natural Products Research, The University of Mississippi, University, MS, 38677, USA.
PMID: 37392312 DOI: 10.1007/978-3-031-26768-0_2

Abstract

The widespread utility of herbal products has been rising considerably worldwide, including both developed and developing countries, leading to the rapid growth of their availability in the United States and globally. This substantial increase in consumption of herbal products has witnessed the emergence of adverse effects upon oral administration of certain of these products, and thus has raised safety concerns. The adverse effects caused by the consumption of certain botanical medicines occur primarily as a result of the poor quality of plant raw materials or the finished products, which inherently may affect safety and/or efficacy. The poor quality of some herbal products can be attributed to a lack of proper quality assurance and quality control. A high demand for herbal products that surpasses production, combined with a desire for maximizing profits, along with a lack of rigorous quality control within some manufacturing facilities have led to the emergence of quality inconsistencies. The underlying causes for this involve the misidentification of plant species, or their substitution, adulteration, or contamination with harmful ingredients. Analytical assessments have revealed there to be frequent and significant compositional variations between marketed herbal products. The inconsistency of the quality of herbal products can be ascribed essentially to the inconsistency of the botanical raw material quality used to manufacture the products. Thus, the quality assurance and the quality control of the botanical raw materials is may contribute significantly to improving the quality and consistency of the quality of the end products. The current chapter focuses on the chemical evaluation of quality and consistency of herbal products, including botanical dietary supplements. Different techniques, instruments, applications, and methods used in identifying, quantifying, and generating chemical fingerprints and chemical profiles of the ingredients of the herbal products will be described. The strengths and weaknesses of the various techniques available will be addressed. Limitations of the other approaches including morphological or microscopic analysis and DNA-based analysis will be presented.

Keywords

Chemical Chemometrics Evaluation Herbal products Metabolomics Quality consistency

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