Cutaneous presentation of cryptococcal infection with subclinical central nervous system involvement secondary to fingolimod therapy.

Shin Yee Chey, Niamh-Anna O'Sullivan, Trevor Beer, Wai K Leong, Allan G Kermode
Author Information
  1. Shin Yee Chey: Department of Neurology, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia. ORCID
  2. Niamh-Anna O'Sullivan: University of New South Wales, Sydney, New South Wales, Australia.
  3. Trevor Beer: Clinipath Pathology, Osborne Park, Australia.
  4. Wai K Leong: Department of Neurology, Royal Perth Hospital, Perth, Western Australia, Australia.
  5. Allan G Kermode: Perron Institute for Neurological and Translational Sciences, QE II Medical Centre, Perth, Australia. ORCID

Abstract

Fingolimod is a multiple sclerosis disease-modifying therapy which sequestrates lymphocytes in the lymph nodes, thereby reducing peripheral blood lymphocytes. Cryptococcal infection is an important adverse effect which should be recognised. We report a case of cutaneous and central nervous system infection who presented with isolated cutaneous symptoms in the absence of neurological or systemic manifestations.

Keywords

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Created with Highcharts 10.0.0infectioncryptococcalcutaneouscentralnervoussystemFingolimodmultiplesclerosistherapylymphocytesdisease-modifyingsequestrateslymphnodestherebyreducingperipheralbloodCryptococcalimportantadverseeffectrecognisedreportcasepresentedisolatedsymptomsabsenceneurologicalsystemicmanifestationsCutaneouspresentationsubclinicalinvolvementsecondaryfingolimodmeningitis

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