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Jan 05, 2024;52 (D1): D909-D918.

HALL: a comprehensive database for human aging and longevity studies.

Hao Li, Song Wu, Jiaming Li, Zhuang Xiong, Kuan Yang, Weidong Ye, Jie Ren, Qiaoran Wang, Muzhao Xiong, Zikai Zheng, Shuo Zhang, Zichu Han, Peng Yang, Beier Jiang, Jiale Ping, Yuesheng Zuo, Xiaoyong Lu, Qiaocheng Zhai, Haoteng Yan, Si Wang, Shuai Ma, Bing Zhang, Jinlin Ye, Jing Qu, Yun-Gui Yang, Feng Zhang, Guang-Hui Liu, Yiming Bao, Weiqi Zhang
Author Information
  1. Hao Li: CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.
  2. Song Wu: CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China. ORCID
  3. Jiaming Li: CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.
  4. Zhuang Xiong: Interdisciplinary Institute for Medical Engineering, Fuzhou University, Fuzhou 350002, China. ORCID
  5. Kuan Yang: CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.
  6. Weidong Ye: Department of Vascular Surgery, Quzhou Affiliated Hospital of Wenzhou Medical University, Beijing 100101, China.
  7. Jie Ren: CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.
  8. Qiaoran Wang: CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.
  9. Muzhao Xiong: CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.
  10. Zikai Zheng: CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.
  11. Shuo Zhang: CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.
  12. Zichu Han: CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.
  13. Peng Yang: CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.
  14. Beier Jiang: Department of Vascular Surgery, Quzhou Affiliated Hospital of Wenzhou Medical University, Beijing 100101, China.
  15. Jiale Ping: CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.
  16. Yuesheng Zuo: CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.
  17. Xiaoyong Lu: CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.
  18. Qiaocheng Zhai: Department of Vascular Surgery, Quzhou Affiliated Hospital of Wenzhou Medical University, Beijing 100101, China.
  19. Haoteng Yan: Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China.
  20. Si Wang: Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China.
  21. Shuai Ma: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
  22. Bing Zhang: CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.
  23. Jinlin Ye: Department of Vascular Surgery, Quzhou Affiliated Hospital of Wenzhou Medical University, Beijing 100101, China.
  24. Jing Qu: State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
  25. Yun-Gui Yang: CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.
  26. Feng Zhang: The Joint Innovation Center for Engineering in Medicine, Quzhou Affiliated Hospital of Wenzhou Medical University, 324000, China.
  27. Guang-Hui Liu: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. ORCID
  28. Yiming Bao: CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.
  29. Weiqi Zhang: CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China. ORCID
PMID: 37870433 DOI: 10.1093/nar/gkad880

Abstract

Diverse individuals age at different rates and display variable susceptibilities to tissue aging, functional decline and aging-related diseases. Centenarians, exemplifying extreme longevity, serve as models for healthy aging. The field of human aging and longevity research is rapidly advancing, garnering significant attention and accumulating substantial data in recent years. Omics technologies, encompassing phenomics, genomics, transcriptomics, proteomics, metabolomics and microbiomics, have provided multidimensional insights and revolutionized cohort-based investigations into human aging and longevity. Accumulated data, covering diverse cells, tissues and cohorts across the lifespan necessitates the establishment of an open and integrated database. Addressing this, we established the Human Aging and Longevity Landscape (HALL), a comprehensive multi-omics repository encompassing a diverse spectrum of human cohorts, spanning from young adults to centenarians. The core objective of HALL is to foster healthy aging by offering an extensive repository of information on biomarkers that gauge the trajectory of human aging. Moreover, the database facilitates the development of diagnostic tools for aging-related conditions and empowers targeted interventions to enhance longevity. HALL is publicly available at https://ngdc.cncb.ac.cn/hall/index.

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Grants

  1. 2022YFA1103700/National Key Research and Development Program of China
  2. XDB38030200/Strategic Priority Research Program of the Chinese Academy of Sciences
  3. 2022K46/Quzhou Technology Projects
  4. 32121001/National Natural Science Foundation of China
  5. XDA16000000/Strategic Priority Research Program of the Chinese Academy of Sciences
  6. YSBR-076/CAS Project for Young Scientists in Basic Research
  7. Z190019/Program of the Beijing Natural Science Foundation
  8. CAS-WX2021SF-0301/Informatization Plan of Chinese Academy of Sciences
  9. 2021-1045/New Cornerstone Science Foundation
  10. E1CAZW0401/Youth Innovation Promotion Association of CAS
  11. 12300927/Excellent Young Talents Program of Capital Medical University
  12. 11000023T000002036310/Project for Technology Development of Beijing-affiliated Medical Research Institutes
  13. YESS20210002/Young Elite Scientists Sponsorship Program by CAST
  14. BPHR202203105/Excellent Young Talents Training Program for the Construction of Beijing Municipal University Teacher Team

MeSH Term

Aged, 80 and over
Humans
Young Adult
Aging
Biomarkers
Disease Susceptibility
Genomics
Longevity
Multiomics
Databases, Factual

Chemicals

Biomarkers
Journal Article

Links to CNCB-NGDC Resources

Database Commons: DBC009042 (HALL)
Article has an altmetric score of 13

Word Cloud

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