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Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology
03 01, 2024;37 (1): 32-39.

Cognitive Intra-individual Variability in the Laboratory Is Associated With Greater Executive Dysfunction in the Daily Lives of Older Adults With HIV.

Natalie C Ridgely, Steven Paul Woods, Troy A Webber, Andrea I Mustafa, Darrian Evans
Author Information
  1. Natalie C Ridgely: Department of Psychology, University of Houston, Houston, Texas.
  2. Steven Paul Woods: Department of Psychology, University of Houston, Houston, Texas.
  3. Troy A Webber: Michael E. DeBakey VA Medical Center, Houston, Texas.
  4. Andrea I Mustafa: Department of Psychology, University of Houston, Houston, Texas.
  5. Darrian Evans: University of Louisville, Louisville, Kentucky.
PMID: 37871277 DOI: 10.1097/WNN.0000000000000358

Abstract

BACKGROUND: Executive dysfunction, which is common among persons with HIV (PWH), can have an adverse impact on health behaviors and quality of life. Intra-individual variability (IIV) is a measure of within-person variability across cognitive tests that is higher in PWH and is thought to reflect cognitive dyscontrol.
OBJECTIVE: To assess whether cognitive IIV in the laboratory is associated with self-reported Executive dysfunction in daily life among older PWH.
METHOD: Participants included 71 PWH aged ���50 years who completed six subtests from the Cogstate battery and two subscales from the Frontal Systems Behavior Scale (FrSBe; self-report version). Cognitive IIV was calculated from the Cogstate as the coefficient of variation derived from age-adjusted normative T scores.
RESULTS: Cognitive IIV as measured by the Cogstate showed a significant, positive, medium-sized association with current FrSBe ratings of Executive dysfunction but not disinhibition.
CONCLUSION: Higher cognitive IIV in the laboratory as measured by the Cogstate may be related to the expression of HIV-associated symptoms of Executive dysfunction in daily life for older PWH.

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Grants

  1. P30 MH062512/NIMH NIH HHS
  2. R01 MH073419/NIMH NIH HHS

MeSH Term

Humans
Aged
Quality of Life
Cognitive Dysfunction
Neuropsychological Tests
Cognition
HIV Infections
Journal Article
Article has an altmetric score of 1

Word Cloud

Created with Highcharts 10.0.0PWHIIVdysfunctioncognitiveCogstatelifeexecutiveCognitiveExecutiveamongHIVIntra-individualvariabilitylaboratorydailyolderFrSBemeasuredBACKGROUND:commonpersonscanadverseimpacthealthbehaviorsqualitymeasurewithin-personacrosstestshigherthoughtreflectdyscontrolOBJECTIVE:assesswhetherassociatedself-reportedMETHOD:Participantsincluded71aged���50yearscompletedsixsubtestsbatterytwosubscalesFrontalSystemsBehaviorScaleself-reportversioncalculatedcoefficientvariationderivedage-adjustednormativeTscoresRESULTS:showedsignificantpositivemedium-sizedassociationcurrentratingsdisinhibitionCONCLUSION:HighermayrelatedexpressionHIV-associatedsymptomsVariabilityLaboratoryAssociatedGreaterDysfunctionDailyLivesOlderAdults

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