Based on the directed relation graph with error propagation (DRGEP) reduction method, a detailed mechanism consisting of 119 species and 527 reactions for n-decane was simplified. As a result, a skeletal mechanism comprising 32 species and 73 reactions was derived. Subsequently, the quasi-steady state approximation (QSSA) reduction method was employed to further simplify the skeletal mechanism, resulting in a reduced mechanism with 18 species and 14 global reactions. A comparison between the reduced mechanism, skeletal mechanism, and detailed mechanism revealed that the reduced and skeletal mechanisms successfully replicated the combustion characteristics of the detailed mechanism under a range of initial conditions. These models can be credibly incorporated into large-scale combustion simulation, serving as a solid foundation for enhancing computational efficiency.