-induced mitochondrial dysfunction inhibits proinflammatory cytokine secretion and enhances cytotoxicity in mouse macrophages in a reactive oxygen species (ROS)-dependent way.

Haitao Yang, Yan Wang, Hui Fan, Feixue Liu, Huimiao Feng, Xueqing Li, Mingyi Chu, Enzhuang Pan, Daoyang Teng, Huizhen Chen, Jingquan Dong
Author Information
  1. Haitao Yang: Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy, Jiangsu Ocean University, Lianyungang 222005, China.
  2. Yan Wang: Department of Medicine Laboratory, the Second People's Hospital of Lianyungang Affiliated to Kangda College of Nanjing Medical University, the Second People's Hospital of Lianyungang City, Lianyungang 222000, China.
  3. Hui Fan: Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy, Jiangsu Ocean University, Lianyungang 222005, China.
  4. Feixue Liu: Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy, Jiangsu Ocean University, Lianyungang 222005, China.
  5. Huimiao Feng: Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy, Jiangsu Ocean University, Lianyungang 222005, China.
  6. Xueqing Li: Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy, Jiangsu Ocean University, Lianyungang 222005, China.
  7. Mingyi Chu: Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy, Jiangsu Ocean University, Lianyungang 222005, China.
  8. Enzhuang Pan: Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy, Jiangsu Ocean University, Lianyungang 222005, China.
  9. Daoyang Teng: Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy, Jiangsu Ocean University, Lianyungang 222005, China.
  10. Huizhen Chen: Institute of Neuroscience, the First People's Hospital of Lianyungang, Lianyungang 222000, China. 2018000029@jou.edu.cn.
  11. Jingquan Dong: Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy, Jiangsu Ocean University, Lianyungang 222005, China. 2018000029@jou.edu.cn.

Abstract

No abstract text available.

References

  1. J Zhejiang Univ Sci B. 2021 Sept 15;22(9):782-790 [PMID: 34514758]
  2. Exp Eye Res. 2022 Feb;215:108903 [PMID: 34951999]
  3. Front Immunol. 2020 Aug 14;11:1649 [PMID: 32922385]
  4. Autophagy. 2023 Feb;19(2):401-414 [PMID: 35678504]
  5. Redox Biol. 2020 Sep;36:101679 [PMID: 32818797]
  6. Nat Cell Biol. 2018 Sep;20(9):1013-1022 [PMID: 30154567]
  7. Nat Microbiol. 2020 Nov;5(11):1418-1427 [PMID: 32807891]
  8. Drug Discov Today. 2019 Jan;24(1):350-359 [PMID: 30036575]
  9. Autophagy. 2022 May;18(5):1090-1107 [PMID: 34482812]
  10. Curr Neuropharmacol. 2021;19(8):1202-1224 [PMID: 33380301]
  11. FASEB J. 2020 Jul;34(7):9156-9179 [PMID: 32413239]
  12. Clin Oral Investig. 2021 Jun;25(6):3919-3928 [PMID: 33404763]
  13. Int J Mol Sci. 2021 Dec 21;23(1): [PMID: 35008429]
  14. Nat Immunol. 2019 Apr;20(4):433-446 [PMID: 30804553]
  15. Microbes Infect. 2022 Jun;24(4):104950 [PMID: 35139390]
  16. Mediators Inflamm. 2019 Jan 8;2019:2471215 [PMID: 30728749]
  17. Gut Microbes. 2022 Jan-Dec;14(1):2143224 [PMID: 36476073]
  18. Infect Immun. 2015 Oct 14;84(1):56-66 [PMID: 26467446]
  19. Redox Biol. 2019 Sep;26:101254 [PMID: 31229841]
  20. Cell Rep. 2019 May 14;27(7):2075-2091.e5 [PMID: 31091447]
  21. Biotechnol Adv. 2019 Jan - Feb;37(1):177-192 [PMID: 30500353]
  22. Transl Res. 2018 Dec;202:52-68 [PMID: 30165038]
  23. Med Sci Monit. 2021 Jan 25;27:e930886 [PMID: 33487628]
  24. Int J Mol Sci. 2021 Mar 18;22(6): [PMID: 33803907]
  25. Front Immunol. 2019 Oct 23;10:2461 [PMID: 31708919]
  26. Int J Mol Sci. 2021 Oct 20;22(21): [PMID: 34768767]
  27. Mol Cells. 2018 Jan 31;41(1):18-26 [PMID: 29370689]
  28. Curr Biol. 2018 Feb 19;28(4):R170-R185 [PMID: 29462587]
  29. Redox Biol. 2020 Sep;36:101660 [PMID: 32750667]
  30. J Clin Invest. 2020 Nov 2;130(11):5858-5874 [PMID: 32759503]
  31. Drugs. 2021 Dec;81(18):2117-2131 [PMID: 34743315]
  32. Zool Res. 2022 Mar 18;43(2):285-300 [PMID: 35238186]
  33. Clin Microbiol Infect. 2020 Mar;26(3):313-318 [PMID: 31306794]
  34. Front Immunol. 2022 Mar 09;13:827004 [PMID: 35355995]

Grants

  1. 21KJB230001/the Basic Science (Natural Science) Research Project of Higher Education of Jiangsu Province
  2. HY202101/the Open-End Funds of Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening
  3. SF2140/the Lianyungang City Science and Technology Bureau Science and Technology Plan (Social Development) Project
  4. Z2022070/the 2022 Medical Research guiding Project of Jiangsu Provincial Health Commission
  5. SJCX23_1838/the 2023 Jiangsu Graduate Research Innovation Plan Project

MeSH Term

Mice
Animals
Reactive Oxygen Species
Pseudomonas aeruginosa
Macrophages
Mitochondria
Cytokines

Chemicals

Reactive Oxygen Species
Cytokines

Word Cloud

Created with Highcharts 10.0.0-inducedmitochondrialdysfunctioninhibitsproinflammatorycytokinesecretionenhancescytotoxicitymousemacrophagesreactiveoxygenspeciesROS-dependentway

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