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Current drug delivery
2025;22 (2): 195-214.

Intelligent Drug Delivery: Pioneering Stimuli-Responsive Systems to Revolutionize Disease Management- An In-depth Exploration.

Badarinadh Kallepalli, Unnati Garg, Neha Jain, Rohan Nagpal, Sakshi Malhotra, Triveni Tiwari, Shreya Kaul, Upendra Nagaich
Author Information
  1. Badarinadh Kallepalli: Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Sector 125, Noida, Uttar Pradesh, India.
  2. Unnati Garg: Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Sector 125, Noida, Uttar Pradesh, India.
  3. Neha Jain: Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Sector 125, Noida, Uttar Pradesh, India. ORCID
  4. Rohan Nagpal: Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Sector 125, Noida, Uttar Pradesh, India.
  5. Sakshi Malhotra: Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Sector 125, Noida, Uttar Pradesh, India.
  6. Triveni Tiwari: Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Sector 125, Noida, Uttar Pradesh, India.
  7. Shreya Kaul: Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Sector 125, Noida, Uttar Pradesh, India. ORCID
  8. Upendra Nagaich: Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Sector 125, Noida, Uttar Pradesh, India. ORCID
PMID: 38310439 DOI: 10.2174/0115672018278641231221051359

Abstract

In recent years, there has been an escalating interest in stimuli-responsive drug delivery systems (SRDDS) due to their ability to revolutionize the delivery of therapeutics. SRDDSs offer a multitude of benefits in comparison to conventional drug delivery systems (DDS), including spatiotemporal control of drug release, targeted delivery, and improved therapeutic efficacy. The development of various classes of stimuli-responsive DDS, such as pH-responsive, temperature-responsive, photo-responsive, redox responsive systems, has been propelled by advances in materials science, nanotechnology, and biotechnology. These systems exploit specific environmental or physiological cues to trigger drug release in a precisely controlled manner, making them highly promising for the treatment of various diseases. In this review article, an in-depth exploration of the principles, mechanisms, and applications of SRDDS in the context of diverse pathologies such as cancer, arthritis, Alzheimer's disease, atherosclerosis and tissue engineering has been provided. Furthermore, this article delves into the discussion of recent patents, market overview and the progress of research in clinical trials. Overall, this article underscores the transformative potential of SRDDS in enabling personalized, precise, and effective drug delivery for the treatment of the above-mentioned diseases.

Keywords

Chemical-responsive drug delivery systems Intelligent Polymers Intelligent biomaterials Physicalresponsive drug delivery systems SRDDS market overview Stimuli-responsive drug delivery systems (SRDDS) endogenous/exogenous stimuli-responsive DDS.

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MeSH Term

Humans
Drug Delivery Systems
Animals
Drug Liberation
Neoplasms
Hydrogen-Ion Concentration
Tissue Engineering
Journal Article Review

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