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Epigenomics
Mar 21, 2024;

Coregulatory effects of multiple histone modifications in key ferroptosis-related genes for lung adenocarcinoma.

Ye-Chen Qi, Hui Bai, Si-Le Hu, Shu-Juan Li, Qian-Zhong Li
Author Information
  1. Ye-Chen Qi: Laboratory of Theoretical Biophysics, School of Physical Science & Technology, Inner Mongolia University, Hohhot, 010021, China. ORCID
  2. Hui Bai: Laboratory of Theoretical Biophysics, School of Physical Science & Technology, Inner Mongolia University, Hohhot, 010021, China.
  3. Si-Le Hu: Laboratory of Theoretical Biophysics, School of Physical Science & Technology, Inner Mongolia University, Hohhot, 010021, China.
  4. Shu-Juan Li: Laboratory of Theoretical Biophysics, School of Physical Science & Technology, Inner Mongolia University, Hohhot, 010021, China.
  5. Qian-Zhong Li: Laboratory of Theoretical Biophysics, School of Physical Science & Technology, Inner Mongolia University, Hohhot, 010021, China. ORCID
PMID: 38511238 DOI: 10.2217/epi-2023-0403

Abstract

The present study was designed to investigate the coregulatory effects of multiple histone modifications (HMs) on gene expression in lung adenocarcinoma (LUAD). Ten histones for LUAD were analyzed using ChIP-seq and RNA-seq data. An innovative computational method is proposed to quantify the coregulatory effects of multiple HMs on gene expression to identify strong coregulatory genes and regions. This method was applied to explore the coregulatory mechanisms of key ferroptosis-related genes in LUAD. Nine strong coregulatory regions were identified for six ferroptosis-related genes with diverse coregulatory patterns (, , , , and ). This quantitative method could be used to identify important HM coregulatory genes and regions that may be epigenetic regulatory targets in cancers.

Keywords

computational method coregulation drug sensitivity ferroptosis gene expression histone modifications lung adenocarcinoma tumor microenvironment

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Grants

  1. Nos. 32160216, 62361047/National Natural Science Foundation of China
Journal Article

Word Cloud

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