Horizons in Endometriosis: Proceedings of the Montreux Reproductive Summit, 14-15 July 2023.

A Vall��e, E Saridogan, F Petraglia, J Keckstein, N Polyzos, C Wyns, L Gianaroli, B Tarlatzis, J M Ayoubi, A Feki, Montreux Reproductive Summit Working Group
Author Information

Abstract

Endometriosis is a complex and chronic gynaecological disorder that affects millions of women worldwide, leading to significant morbidity and impacting reproductive health. This condition affects up to 10% of women of reproductive age and is characterised by the presence of endometrial-like tissue outside the uterus, potentially leading to symptoms such as chronic pelvic pain, dysmenorrhoea, dyspareunia, and infertility. The Montreux summit brought a number of experts in this field together to provide a platform for discussion and exchange of ideas. These proceedings summarise the six main topics that were discussed at this summit to shed light on future directions of endometriosis classification, diagnosis, and therapeutical management. The first question addressed the possibility of preventing endometriosis in the future by identifying risk factors, genetic predispositions, and further understanding of the pathophysiology of the condition to develop targeted interventions. The clinical presentation of endometriosis is varied, and the correlation between symptoms severity and disease extent is unclear. While there is currently no universally accepted optimal classification system for endometriosis, several attempts striving towards its optimisation - each with its own advantages and limitations - were discussed. The ideal classification should be able to reconcile disease status based on the various diagnostic tools, and prognosis to guide proper patient tailored management. Regarding diagnosis, we focused on future tools and critically discussed emerging approaches aimed at reducing diagnostic delay. Preserving fertility in endometriosis patients was another debatable aspect of management that was reviewed. Moreover, besides current treatment modalities, potential novel medical therapies that can target underlying mechanisms, provide effective symptom relief, and minimise side effects in endometriotic patients were considered, including hormonal therapies, immunomodulation, and regenerative medicine. Finally, the question of hormonal substitution therapy after radical treatment for endometriosis was debated, weighing the benefits of hormone replacement.

Keywords

References

  1. Fertil Steril. 1998 Apr;69(4):702-8 [PMID: 9548161]
  2. BJOG. 2021 Jan;128(1):25-35 [PMID: 32558987]
  3. Abdom Radiol (NY). 2020 Jun;45(6):1790-1799 [PMID: 31701193]
  4. Obstet Gynecol. 1988 Sep;72(3 Pt 1):323-7 [PMID: 2970029]
  5. Int J Environ Res Public Health. 2021 Jun 19;18(12): [PMID: 34205332]
  6. Nutrients. 2023 Jun 16;15(12): [PMID: 37375677]
  7. Front Immunol. 2019 Jun 12;10:1324 [PMID: 31249571]
  8. Fertil Steril. 1979 Dec;32(6):633-4 [PMID: 510564]
  9. Hum Reprod. 2017 Feb;32(2):315-324 [PMID: 27920089]
  10. Obstet Gynecol. 1993 Oct;82(4 Pt 2 Suppl):642-4 [PMID: 8377997]
  11. Front Biosci (Elite Ed). 2012 Jan 01;4(1):23-40 [PMID: 22201853]
  12. Annu Rev Pathol. 2020 Jan 24;15:71-95 [PMID: 31479615]
  13. Fertil Steril. 1981 Mar;35(3):368-9 [PMID: 7202765]
  14. Curr Opin Obstet Gynecol. 2021 Jun 1;33(3):225-231 [PMID: 33769421]
  15. Expert Rev Pharmacoecon Outcomes Res. 2018 Feb;18(1):1-4 [PMID: 29186995]
  16. Fertil Steril. 2016 Apr;105(4):997-1002 [PMID: 26772788]
  17. Sci Rep. 2019 Apr 1;9(1):5410 [PMID: 30932000]
  18. Hum Reprod. 2012 Jan;27(1):265-72 [PMID: 22025227]
  19. Minerva Obstet Gynecol. 2021 Apr;73(2):193-214 [PMID: 33851803]
  20. J Obstet Gynaecol Can. 2022 Feb;44(2):135-141 [PMID: 34562632]
  21. Ultrasound Obstet Gynecol. 2012 Nov;40(5):592-603 [PMID: 22535651]
  22. Int J Clin Oncol. 2009 Oct;14(5):378-82 [PMID: 19856043]
  23. Biomolecules. 2022 Sep 14;12(9): [PMID: 36139138]
  24. Endocr J. 2009;56(6):729-37 [PMID: 19609045]
  25. Facts Views Vis Obgyn. 2024 Jun;16(2):127-144 [PMID: 38807551]
  26. Cells. 2023 Apr 23;12(9): [PMID: 37174627]
  27. Trends Endocrinol Metab. 2018 Aug;29(8):535-548 [PMID: 29934050]
  28. PLoS One. 2015 Feb 13;10(2):e0117387 [PMID: 25679207]
  29. Reprod Biomed Online. 2023 Jul;47(1):71-76 [PMID: 37202318]
  30. Nat Rev Microbiol. 2019 Mar;17(3):156-166 [PMID: 30546113]
  31. Reprod Biomed Online. 2021 Apr;42(4):725-732 [PMID: 33573907]
  32. Drug Des Devel Ther. 2023 Feb 08;17:369-380 [PMID: 36789095]
  33. Cancer Immunol Immunother. 2018 Oct;67(10):1635-1646 [PMID: 30121899]
  34. Yearb Med Inform. 2019 Aug;28(1):16-26 [PMID: 31419814]
  35. Biomed Res Int. 2019 Jul 25;2019:3673060 [PMID: 31428634]
  36. Fertil Steril. 2011 Sep;96(3):685-91 [PMID: 21802672]
  37. Fertil Steril. 2014 Mar;101(3):656-663.e1 [PMID: 24355045]
  38. Fertil Steril. 2018 Oct;110(5):932-940.e1 [PMID: 30316440]
  39. Fertil Steril. 2016 Dec;106(7):1552-1571.e2 [PMID: 27817837]
  40. Clin Obstet Gynecol. 2010 Jun;53(2):413-9 [PMID: 20436318]
  41. Am J Obstet Gynecol. 2007 Apr;196(4):391.e1-7; discussion 391.e7-8 [PMID: 17403431]
  42. Am J Pathol. 2009 Aug;175(2):547-56 [PMID: 19574425]
  43. Sao Paulo Med J. 2008 May 1;126(3):190-3 [PMID: 18711660]
  44. Gynecol Obstet Fertil Senol. 2023 Feb;51(2):117-122 [PMID: 36423880]
  45. Front Immunol. 2013 Jan 28;4:9 [PMID: 23372570]
  46. Arch Gynecol Obstet. 2012 Sep;286(3):667-70 [PMID: 22562384]
  47. J Assist Reprod Genet. 2014 Sep;31(9):1195-204 [PMID: 24965760]
  48. Int J Mol Sci. 2021 Sep 28;22(19): [PMID: 34638843]
  49. Hum Reprod. 2005 Jul;20(7):2014-20 [PMID: 15817589]
  50. Eur J Obstet Gynecol Reprod Biol. 2017 Feb;209:61-66 [PMID: 27503693]
  51. Am J Obstet Gynecol. 2006 Aug;195(2):421-5 [PMID: 16681984]
  52. Maturitas. 1999 Aug 16;32(3):189-93 [PMID: 10515676]
  53. Gynecol Endocrinol. 2021 Apr;37(4):287-293 [PMID: 33569996]
  54. Fertil Steril. 2017 Aug;108(2):284-288 [PMID: 28651959]
  55. J Clin Endocrinol Metab. 2012 Sep;97(9):3146-54 [PMID: 22723324]
  56. Life Sci. 2023 Jun 1;322:121658 [PMID: 37023951]
  57. Hum Reprod. 2023 Aug 1;38(8):1499-1508 [PMID: 37308317]
  58. Adv Ther. 2018 Mar;35(3):408-423 [PMID: 29450864]
  59. Fertil Steril. 1993 Mar;59(3):516-21 [PMID: 8458450]
  60. Fertil Steril. 2012 Sep;98(3):702-712.e6 [PMID: 22728052]
  61. Front Med (Lausanne). 2023 Jun 28;10:1193749 [PMID: 37448805]
  62. Eur J Radiol. 2015 Apr;84(4):568-74 [PMID: 25604906]
  63. Endocrinology. 2007 Aug;148(8):3814-26 [PMID: 17510236]
  64. J Womens Health (Larchmt). 2021 Apr;30(4):569-578 [PMID: 32975461]
  65. Medicina (Kaunas). 2019 Aug 14;55(8): [PMID: 31416164]
  66. Fertil Steril. 2001 Nov;76(5):929-35 [PMID: 11704113]
  67. Cancer Epidemiol Biomarkers Prev. 2008 Apr;17(4):921-9 [PMID: 18398032]
  68. Hum Reprod. 2014 Nov;29(11):2446-56 [PMID: 25205755]
  69. Hum Reprod Update. 2017 Jul 1;23(4):481-500 [PMID: 28498913]
  70. Biomed Res Int. 2018 Mar 20;2018:6217812 [PMID: 29750165]
  71. Front Biosci (Schol Ed). 2011 Jun 01;3(4):1196-204 [PMID: 21622265]
  72. J Obstet Gynaecol. 2007 May;27(4):433-4 [PMID: 17654209]
  73. Endocrinology. 2002 Jun;143(6):2119-38 [PMID: 12021176]
  74. Fertil Steril. 1999 Mar;71(3):420-4 [PMID: 10065775]
  75. Fertil Steril. 2017 Mar;107(3):533-536 [PMID: 28162779]
  76. Cochrane Database Syst Rev. 2018 May 22;5:CD001019 [PMID: 29786828]
  77. Am J Reprod Immunol. 2019 Aug;82(2):e13147 [PMID: 31087436]
  78. Fertil Steril. 1982 Aug;38(2):171-6 [PMID: 7106312]
  79. Hum Reprod Open. 2020 Feb 12;2020(1):hoaa002 [PMID: 32064361]
  80. J Minim Invasive Gynecol. 2021 Nov;28(11):1941-1950.e1 [PMID: 34583009]
  81. J Med Assoc Thai. 2003 Aug;86(8):702-7 [PMID: 12948267]
  82. Climacteric. 2018 Jun;21(3):249-255 [PMID: 29609503]
  83. Fertil Steril. 1997 May;67(5):817-21 [PMID: 9130884]
  84. Acta Obstet Gynecol Scand. 2021 Jul;100(7):1165-1175 [PMID: 33483970]
  85. Obstet Gynecol. 1998 May;91(5 Pt 1):673-7 [PMID: 9572209]
  86. Eur Radiol. 2017 Jul;27(7):2765-2775 [PMID: 27921160]
  87. Fertil Steril. 2002 Feb;77(2):303-8 [PMID: 11821087]
  88. CMAJ. 2023 Mar 14;195(10):E363-E371 [PMID: 36918177]
  89. Best Pract Res Clin Obstet Gynaecol. 2018 Aug;51:25-33 [PMID: 30245115]
  90. Differentiation. 2011 Oct;82(3):117-26 [PMID: 21612855]
  91. Int J Mol Sci. 2023 Feb 14;24(4): [PMID: 36835217]
  92. Obstet Gynecol. 2018 Dec;132(6):e249-e258 [PMID: 30461694]
  93. Environ Pollut. 2021 Oct 1;286:117410 [PMID: 34052646]
  94. J Menopausal Med. 2013 Dec;19(3):151-3 [PMID: 25371883]
  95. Contraception. 2009 Jan;79(1):29-34 [PMID: 19041438]
  96. PLoS One. 2016 Oct 24;11(10):e0165347 [PMID: 27776183]
  97. Medicine (Baltimore). 2018 Feb;97(8):e9536 [PMID: 29465552]
  98. J Hum Reprod Sci. 2014 Jul;7(3):170-4 [PMID: 25395741]
  99. Cochrane Database Syst Rev. 2016 Apr 29;4:CD001750 [PMID: 27126581]
  100. Front Endocrinol (Lausanne). 2022 Jan 24;12:814474 [PMID: 35140688]
  101. J Obstet Gynaecol. 2007 Aug;27(6):605-7 [PMID: 17896261]
  102. Front Med (Lausanne). 2023 Nov 17;10:1303593 [PMID: 38046415]
  103. Hum Reprod Open. 2022 Feb 26;2022(2):hoac009 [PMID: 35350465]
  104. Nutrients. 2021 Jul 24;13(8): [PMID: 34444692]
  105. Climacteric. 2018 Aug;21(4):385-390 [PMID: 29493295]
  106. BMC Womens Health. 2021 Dec 20;21(1):422 [PMID: 34930225]
  107. Sci Transl Med. 2023 Jun 14;15(700):eadd1531 [PMID: 37315109]
  108. Hum Reprod. 2013 Aug;28(8):2140-5 [PMID: 23624580]
  109. Cells. 2019 Aug 13;8(8): [PMID: 31412678]
  110. Cochrane Database Syst Rev. 2009 Jan 21;(1):CD005997 [PMID: 19160262]
  111. Best Pract Res Clin Obstet Gynaecol. 2018 Aug;51:68-91 [PMID: 29530425]
  112. Hum Reprod. 2006 May;21(5):1237-42 [PMID: 16431901]
  113. Rev Endocr Metab Disord. 2022 Jun;23(3):333-355 [PMID: 34405378]
  114. Fertil Steril. 2009 Dec;92(6):1825-33 [PMID: 19019357]
  115. Nat Rev Endocrinol. 2014 May;10(5):261-75 [PMID: 24366116]
  116. Cochrane Database Syst Rev. 2017 Apr 26;4:CD010770 [PMID: 28444736]
  117. Mol Endocrinol. 2001 Dec;15(12):2093-105 [PMID: 11731611]
  118. J Minim Invasive Gynecol. 2013 Nov-Dec;20(6):783-9 [PMID: 24183270]
  119. Stem Cell Reports. 2018 Nov 13;11(5):1136-1155 [PMID: 30392973]
  120. Hum Reprod. 2007 Dec;22(12):3092-7 [PMID: 17947378]
  121. J Pain Res. 2021 Feb 02;14:263-271 [PMID: 33564263]
  122. Eur J Obstet Gynecol Reprod Biol. 2018 Oct;229:172-178 [PMID: 30199816]
  123. Int J Mol Sci. 2021 Sep 29;22(19): [PMID: 34638893]
  124. Facts Views Vis Obgyn. 2019 Jun;11(2):151-157 [PMID: 31824636]
  125. Ultrasound Obstet Gynecol. 2011 Apr;37(4):480-7 [PMID: 21433168]
  126. Eur J Obstet Gynecol Reprod Biol. 2017 Jun;213:17-21 [PMID: 28407512]
  127. J Clin Med. 2023 Jan 28;12(3): [PMID: 36769656]
  128. J Clin Res Pediatr Endocrinol. 2020 Feb 06;12(Suppl 1):7-17 [PMID: 32041388]
  129. Best Pract Res Clin Obstet Gynaecol. 2018 Aug;51:151-168 [PMID: 29551389]
  130. Yeungnam Univ J Med. 2021 Jan;38(1):10-18 [PMID: 32764213]
  131. J Clin Endocrinol Metab. 2000 Aug;85(8):2897-902 [PMID: 10946900]
  132. Contraception. 2016 Sep;94(3):195-201 [PMID: 26723202]
  133. Fertil Steril. 2004 Feb;81(2):290-6 [PMID: 14967362]
  134. Front Syst Neurosci. 2018 Jan 26;12:2 [PMID: 29434541]
  135. Hum Reprod Update. 2017 Mar 1;23(2):139-155 [PMID: 27827818]
  136. Cancers (Basel). 2021 Aug 10;13(16): [PMID: 34439184]
  137. Clinics (Sao Paulo). 2022 May 13;77:100032 [PMID: 35576870]
  138. BJOG. 2024 Mar;131(4):401-414 [PMID: 37814514]
  139. Hum Reprod Update. 2020 Jun 18;26(4):565-585 [PMID: 32412587]
  140. Nat Commun. 2017 Oct 17;8(1):875 [PMID: 29042534]
  141. Front Endocrinol (Lausanne). 2020 Jan 23;11:7 [PMID: 32038499]
  142. Int J Womens Health. 2013 Jul 29;5:449-55 [PMID: 23935389]
  143. Sci Rep. 2022 Nov 29;12(1):20531 [PMID: 36446837]
  144. Reprod Biomed Online. 2020 Jun;40(6):827-834 [PMID: 32295746]
  145. Obstet Gynecol. 2002 Oct;100(4):788-95 [PMID: 12383550]
  146. Fertil Steril. 2018 Jul 1;110(1):122-127 [PMID: 29935810]
  147. Stem Cells Int. 2018 Jun 14;2018:3057624 [PMID: 30013600]
  148. Fertil Steril. 2002 Jun;77(6):1141-7 [PMID: 12057719]
  149. Hum Reprod. 2012 Sep;27(9):2698-711 [PMID: 22736326]
  150. Fertil Steril. 2013 Sep;100(3):761-9 [PMID: 23721717]
  151. Am J Obstet Gynecol. 1992 Feb;166(2):740-5 [PMID: 1536260]
  152. Front Immunol. 2023 Feb 14;14:1134663 [PMID: 36865552]
  153. Fertil Steril. 2017 Nov;108(5):798-805 [PMID: 28911925]
  154. Front Physiol. 2018 Jan 23;9:14 [PMID: 29410629]
  155. Reprod Sci. 2012 Jun;19(6):563-71 [PMID: 22457429]
  156. Hum Reprod. 2014 Oct 10;29(10):2190-8 [PMID: 25085800]
  157. Front Immunol. 2023 Apr 17;14:1128301 [PMID: 37138868]
  158. J Clin Med. 2021 Mar 05;10(5): [PMID: 33807739]
  159. N Engl J Med. 2017 Jul 6;377(1):28-40 [PMID: 28525302]
  160. J Natl Cancer Inst. 2013 Apr 17;105(8):526-35 [PMID: 23543779]
  161. J Transl Med. 2011 Mar 22;9:29 [PMID: 21418664]
  162. Endocr Rev. 2020 Oct 1;41(5): [PMID: 32365199]
  163. Biomedicines. 2022 Nov 08;10(11): [PMID: 36359369]
  164. Cochrane Database Syst Rev. 2016 May 01;(5):CD012179 [PMID: 27132058]
  165. Fertil Steril. 1993 May;59(5):1015-21 [PMID: 8486168]
  166. Oxid Med Cell Longev. 2017;2017:7265238 [PMID: 29057034]
  167. Zentralbl Gynakol. 2005 Oct;127(5):275-81 [PMID: 16195969]
  168. Acta Obstet Gynecol Scand. 2007 Oct;86(10):1158-64 [PMID: 17851817]
  169. Cochrane Database Syst Rev. 2012 Mar 14;(3):CD002122 [PMID: 22419284]
  170. Hum Reprod. 1991 May;6(5):699-702 [PMID: 1939552]
  171. J Steroid Biochem Mol Biol. 2016 Jan;155(Pt A):35-46 [PMID: 26407755]
  172. Cochrane Database Syst Rev. 2016 Feb 26;2:CD009591 [PMID: 26919512]
  173. Eur J Cancer. 2014 Nov;50(17):3003-10 [PMID: 25281525]
  174. Medicines (Basel). 2022 Dec 23;10(1): [PMID: 36662487]
  175. Fertil Steril. 2018 Jul 1;110(1):61-62 [PMID: 29908768]
  176. Front Med (Lausanne). 2021 Apr 07;8:652505 [PMID: 33898487]
  177. Hum Reprod. 2013 Jun;28(6):1552-68 [PMID: 23528916]
  178. Front Glob Womens Health. 2021 Sep 27;2:729601 [PMID: 34816243]
  179. J Reprod Immunol. 2011 Sep;91(1-2):64-70 [PMID: 21831449]
  180. Reprod Med Biol. 2020 Jul 20;20(1):13-19 [PMID: 33488279]
  181. Cell Transplant. 2011;20(1):5-14 [PMID: 21396235]
  182. Environ Pollut. 2020 May;260:114066 [PMID: 32041029]
  183. Fertil Steril. 2006 Dec;86(6):1561-72 [PMID: 17056043]
  184. Fertil Steril. 2010 Oct;94(5):1609-15 [PMID: 19931076]
  185. J Endometr. 2009 Jul 1;1(3-4):157-163 [PMID: 24738024]
  186. Eur J Obstet Gynecol Reprod Biol. 2016 Apr;199:69-75 [PMID: 26901400]
  187. Insights Imaging. 2023 Jul 5;14(1):120 [PMID: 37405519]
  188. J Clin Endocrinol Metab. 2021 Jul 13;106(8):e3221-e3234 [PMID: 33624806]
  189. Biomed Res Int. 2014;2014:191967 [PMID: 25165691]
  190. Fertil Steril. 2009 Mar;91(3):687-93 [PMID: 18314120]
  191. Stem Cell Res Ther. 2019 Feb 26;10(1):68 [PMID: 30808416]
  192. Reprod Biomed Soc Online. 2021 Aug 13;14:20-27 [PMID: 34693042]
  193. Am J Reprod Immunol. 2008 Nov;60(5):383-404 [PMID: 19238747]
  194. Obstet Gynecol Surv. 2012 Jun;67(6):374-81 [PMID: 22713164]
  195. Int J Reprod Med. 2014;2014:179515 [PMID: 25763392]
  196. Gynecol Endocrinol. 2020 May;36(5):441-444 [PMID: 31663401]
  197. Cochrane Database Syst Rev. 2010 Dec 08;(12):CD008475 [PMID: 21154398]
  198. Hum Reprod Open. 2020 Dec 30;2020(4):hoaa053 [PMID: 33409380]
  199. Am J Epidemiol. 2004 Oct 15;160(8):784-96 [PMID: 15466501]
  200. Int J Gynaecol Obstet. 2011 Dec;115(3):294-5 [PMID: 21937040]
  201. J Clin Diagn Res. 2012 Nov;6(9):1531-3 [PMID: 23285448]
  202. Int J Gynecol Pathol. 2001 Apr;20(2):133-9 [PMID: 11293158]
  203. J Clin Endocrinol Metab. 2012 Nov;97(11):4228-35 [PMID: 22969138]
  204. Obstet Gynecol. 2008 Oct;112(4):788-99 [PMID: 18827121]
  205. Ann N Y Acad Sci. 2008 Apr;1127:106-15 [PMID: 18443337]
  206. Inflamm Bowel Dis. 2011 Sep;17(9):1971-8 [PMID: 21830275]
  207. Hum Reprod. 2018 Sep 1;33(9):1657-1668 [PMID: 30016439]
  208. Hum Reprod Update. 2015 Jul-Aug;21(4):500-16 [PMID: 25765863]
  209. J Pediatr Adolesc Gynecol. 2007 Oct;20(5):293-7 [PMID: 17868896]
  210. Ann Transl Med. 2015 Jul;3(11):153 [PMID: 26244140]
  211. Climacteric. 2017 Apr;20(2):138-143 [PMID: 28286987]
  212. Genes (Basel). 2020 Feb 29;11(3): [PMID: 32121467]
  213. Lancet. 2022 Jun 18;399(10343):2267-2279 [PMID: 35717987]
  214. Fertil Steril. 2018 Nov;110(6):1129-1136 [PMID: 30396557]
  215. F1000Res. 2019 Apr 23;8: [PMID: 31069056]
  216. Int J Mol Sci. 2021 Oct 20;22(21): [PMID: 34768770]
  217. J Clin Endocrinol Metab. 2008 May;93(5):1915-23 [PMID: 18270252]
  218. Nat Genet. 2023 Mar;55(3):423-436 [PMID: 36914876]
  219. Clin Obstet Gynecol. 2010 Jun;53(2):420-8 [PMID: 20436319]
  220. Eur J Obstet Gynecol Reprod Biol. 2008 Jun;138(2):187-93 [PMID: 18162283]
  221. Maturitas. 2016 Sep;91:25-35 [PMID: 27451318]
  222. Horm Mol Biol Clin Investig. 2019 Mar 26;37(2): [PMID: 30913034]
  223. N Engl J Med. 2009 Jan 15;360(3):268-79 [PMID: 19144942]
  224. Fertil Steril. 2017 Mar;107(3):568-570 [PMID: 28259257]
  225. Hum Reprod. 2014 Mar;29(3):400-12 [PMID: 24435778]
  226. Fertil Steril. 2010 May 1;93(7):2460-2 [PMID: 20045516]
  227. Stem Cell Res Ther. 2020 Aug 8;11(1):346 [PMID: 32771033]
  228. Fertil Steril. 2020 Apr;113(4):836-844 [PMID: 32145929]
  229. Womens Health (Lond). 2007 Mar;3(2):207-14 [PMID: 19803853]
  230. J Clin Endocrinol Metab. 2014 Nov;99(11):E2188-97 [PMID: 25137424]
  231. Fertil Steril. 2014 Feb;101(2):523-9 [PMID: 24220704]
  232. Arch Gynecol Obstet. 2006 Oct;274(6):389-92 [PMID: 16847632]
  233. Arch Gynecol Obstet. 2023 Jan;307(1):73-85 [PMID: 35829767]
  234. BJOG. 2004 Nov;111(11):1204-12 [PMID: 15521864]
  235. Am J Obstet Gynecol. 2021 Feb;224(2):206.e1-206.e23 [PMID: 32861687]
  236. Int J Womens Health. 2011;3:175-84 [PMID: 21792339]
  237. J Assist Reprod Genet. 2018 May;35(5):735-751 [PMID: 29497954]
  238. Fertil Steril. 2020 Jul;114(1):44-55 [PMID: 32505383]
  239. Ultrasound Obstet Gynecol. 2022 Sep;60(3):309-327 [PMID: 35229963]
  240. J Clin Endocrinol Metab. 2013 Apr;98(4):1376-87 [PMID: 23463657]
  241. Eng Life Sci. 2019 Apr 01;19(5):370-388 [PMID: 32625016]
  242. NEJM Evid. 2023 Jul;2(7):EVIDoa2200282 [PMID: 38320163]
  243. Eur J Obstet Gynecol Reprod Biol. 2014 Dec;183:178-82 [PMID: 25461375]
  244. Sci Rep. 2021 Sep 23;11(1):18877 [PMID: 34556738]
  245. Curr Womens Health Rev. 2018;14(2):189-194 [PMID: 31435203]
  246. Stem Cell Rev Rep. 2010 Sep;6(3):367-80 [PMID: 20336395]
  247. Semin Reprod Med. 2001 Dec;19(4):295-303 [PMID: 11727171]
  248. Hum Reprod Update. 2019 Jul 1;25(4):473-485 [PMID: 30809650]
  249. PLoS One. 2019 Oct 10;14(10):e0223316 [PMID: 31600241]
  250. PLoS One. 2014 May 23;9(5):e97311 [PMID: 24859236]
  251. Front Digit Health. 2020 Dec 18;2:600604 [PMID: 34713065]
  252. Clin Med Insights Reprod Health. 2019 Sep 03;13:1179558119873386 [PMID: 31516316]
  253. Hum Reprod Open. 2019 Jun 12;2019(3):hoz009 [PMID: 31206037]
  254. J Clin Endocrinol Metab. 2018 Dec 1;103(12):4561-4568 [PMID: 30357380]
  255. Open Access J Contracept. 2015 Jul 27;6:105-115 [PMID: 29386928]
  256. Fertil Steril. 2014 Apr;101(4):1031-7 [PMID: 24502890]
  257. Cancer Res. 2021 Sep 1;81(17):4485-4498 [PMID: 34162680]
  258. Front Endocrinol (Lausanne). 2021 Apr 13;12:661707 [PMID: 33927696]
  259. Int J Reprod Biomed. 2021 Jun 23;19(5):449-456 [PMID: 34278198]
  260. J Zhejiang Univ Sci B. 2009 Jul;10(7):483-92 [PMID: 19585665]
  261. Hum Reprod. 2020 Jul 1;35(7):1589-1600 [PMID: 32619220]
  262. F S Rep. 2022 Nov 21;4(2 Suppl):40-45 [PMID: 37223763]
  263. J Clin Endocrinol Metab. 2009 Feb;94(2):615-22 [PMID: 19001520]
  264. Fertil Steril. 2008 Nov;90(5):1583-8 [PMID: 18164001]
  265. PLoS One. 2015 Sep 17;10(9):e0138438 [PMID: 26379041]
  266. Reprod Sci. 2020 Jan;27(1):39-45 [PMID: 32046437]
  267. Fertil Steril. 2012 Dec;98(6):1531-8 [PMID: 22975114]
  268. Best Pract Res Clin Obstet Gynaecol. 2018 Aug;51:92-101 [PMID: 29559388]
  269. Hum Reprod. 2015 Jun;30(6):1280-6 [PMID: 25883035]
  270. Hum Reprod. 2003 Jul;18(7):1512-5 [PMID: 12832380]
  271. Nat Cell Biol. 2011 May;13(5):497-505 [PMID: 21540845]
  272. Clin Obstet Gynecol. 2020 Sep;63(3):536-543 [PMID: 32366763]
  273. Gynecol Oncol. 2018 Jun;149(3):585-591 [PMID: 29572027]
  274. J Pediatr Adolesc Gynecol. 2020 Dec;33(6):623-630 [PMID: 32736134]
  275. Womens Health (Lond). 2015 Aug;11(5):711-5 [PMID: 26343168]
  276. Biomed Res Int. 2015;2015:795976 [PMID: 26247027]
  277. Fertil Steril. 1990 Sep;54(3):419-27 [PMID: 2118858]
  278. Endocrinology. 2013 Nov;154(11):3984-9 [PMID: 23928373]
  279. Hum Reprod. 2022 Sep 30;37(10):2359-2365 [PMID: 36066464]
  280. Reprod Biomed Online. 2020 Jul;41(1):37-43 [PMID: 32456967]
  281. Pak J Pharm Sci. 2018 Sep;31(5(Special)):2197-2201 [PMID: 30463812]
  282. Biol Pharm Bull. 2021;44(10):1524-1529 [PMID: 34602561]
  283. Clin Cancer Res. 2009 Jan 15;15(2):431-40 [PMID: 19147747]
  284. Fertil Steril. 2014 Jul;102(1):151-159.e5 [PMID: 24825428]
  285. Front Endocrinol (Lausanne). 2021 Sep 09;12:724632 [PMID: 34566891]
  286. Reproduction. 2019 Oct;158(4):R139-R154 [PMID: 30970326]
  287. Fertil Steril. 1988 Nov;50(5):716-20 [PMID: 3181483]
  288. Signal Transduct Target Ther. 2022 Mar 21;7(1):92 [PMID: 35314676]

Word Cloud

Created with Highcharts 10.0.0endometriosisclassificationdiscussedfuturediagnosismanagementtreatmentEndometriosischronicaffectswomenleadingreproductiveconditionsymptomsMontreuxsummitprovidequestiondisease-diagnostictoolsfertilitypatientstherapieshormonalcomplexgynaecologicaldisordermillionsworldwidesignificantmorbidityimpactinghealth10%agecharacterisedpresenceendometrial-liketissueoutsideuteruspotentiallypelvicpaindysmenorrhoeadyspareuniainfertilitybroughtnumberexpertsfieldtogetherplatformdiscussionexchangeideasproceedingssummarisesixmaintopicsshedlightdirectionstherapeuticalfirstaddressedpossibilitypreventingidentifyingriskfactorsgeneticpredispositionsunderstandingpathophysiologydeveloptargetedinterventionsclinicalpresentationvariedcorrelationseverityextentunclearcurrentlyuniversallyacceptedoptimalsystemseveralattemptsstrivingtowardsoptimisationadvantageslimitationsidealablereconcilestatusbasedvariousprognosisguideproperpatienttailoredRegardingfocusedcriticallyemergingapproachesaimedreducingdelayPreservinganotherdebatableaspectreviewedMoreoverbesidescurrentmodalitiespotentialnovelmedicalcantargetunderlyingmechanismseffectivesymptomreliefminimisesideeffectsendometrioticconsideredincludingimmunomodulationregenerativemedicineFinallysubstitutiontherapyradicaldebatedweighingbenefitshormonereplacementHorizonsEndometriosis:ProceedingsReproductiveSummit14-15July2023preventionbiomarkersmenopauseartificialintelligence

Similar Articles

Cited By