MR Imaging-based Biomarker Development in Hemorrhagic Stroke Patients Including Brain Iron Quantification, Diffusion Tensor Imaging, and Phenomenon of Ultra-early Erythrolysis.
Momodou G Bah, Ehsan Dowlati, Max Fleigner, Sravanthi Koduri, Aditya Pandey, Leanne Y Lin, Thomas L Chenevert, Jonathan Troost, Guohua Xi, Richard Keep, Neeraj Chaudhary
Author Information
Momodou G Bah: Michigan State University College of Human Medicine, Lansing, MI, USA.
Ehsan Dowlati: Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA.
Max Fleigner: Oakland University, William Beaumont School of Medicine, Detroit, MI, USA.
Sravanthi Koduri: Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA.
Aditya Pandey: Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA; Department of Radiology, University of Michigan, Ann Arbor, MI 48109, USA.
Leanne Y Lin: Department of Radiology, University of Michigan, Ann Arbor, MI 48109, USA.
Thomas L Chenevert: Department of Radiology, University of Michigan, Ann Arbor, MI 48109, USA.
Jonathan Troost: Michigan Institute for Clinical and Health Research, University of Michigan, Ann Arbor, MI 48109, USA.
Guohua Xi: Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA.
Richard Keep: Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA.
Neeraj Chaudhary: Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA; Department of Radiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Otorhinolaryngology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: neerajc@med.umich.edu.
This review article discusses the role of MR imaging-based biomarkers in understanding and managing hemorrhagic strokes, focusing on intracerebral hemorrhage (ICH) and aneurysmal subarachnoid hemorrhage. ICH is a severe type of stroke with high mortality and morbidity rates, primarily caused by the rupture of small blood vessels in the brain, resulting in hematoma formation. MR imaging-based biomarkers, including brain iron quantification, ultra-early erythrolysis detection, and diffusion tensor imaging, offer valuable insights for hemorrhagic stroke management. These biomarkers could improve early diagnosis, risk stratification, treatment monitoring, and patient outcomes in the future, revolutionizing our approach to hemorrhagic strokes.
