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Aging and disease
Mar 27, 2024;16 (2): 645-657.

Chronobiology of the Tumor Microenvironment: Implications for Therapeutic Strategies and Circadian-Based Interventions.

Dengxiong Li, Qingxin Yu, Ruicheng Wu, Zhouting Tuo, Weizhen Zhu, Jie Wang, Fanglin Shao, Luxia Ye, Xing Ye, Koo Han Yoo, Mang Ke, Yubo Yang, Wuran Wei, Dechao Feng
Author Information
  1. Dengxiong Li: Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
  2. Qingxin Yu: Department of pathology, Ningbo Clinical Pathology Diagnosis Center, Ningbo, Zhejiang, China.
  3. Ruicheng Wu: Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
  4. Zhouting Tuo: Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
  5. Weizhen Zhu: Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
  6. Jie Wang: Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
  7. Fanglin Shao: Department of Rehabilitation, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
  8. Luxia Ye: Department of Public Research Platform, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, China.
  9. Xing Ye: Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  10. Koo Han Yoo: Department of Urology, Kyung Hee University, Korea.
  11. Mang Ke: Department of Urology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, China.
  12. Yubo Yang: Department of Urology, Three Gorges Hospital, Chongqing University, Wanzhou, Chongqing, China.
  13. Wuran Wei: Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
  14. Dechao Feng: Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
PMID: 38607733 DOI: 10.14336/AD.2024.0327

Abstract

Numerous research works have emphasized the critical role that circadian rhythm plays in the tumor microenvironment (TME). The goal of clarifying chrono-pharmacological strategies for improving cancer treatment in clinical settings is a continuous endeavor. Consequently, to enhance the use of time-based pharmaceutical therapies in oncology, combining existing knowledge on circadian rhythms' roles within the TME is essential. This perspective elucidates the functions of circadian rhythms in the TME across various stages of cancer development, progression, and metastasis. Specifically, aging, angiogenesis, and inflammation are implicated in modulating circadian rhythm within the TME. Furthermore, circadian rhythm exerts a profound influence on current cancer treatments and thereby generates chronotheray to manage tumors. From a TME perspective, circadian rhythm offers promising opportunities for cancer prevention and treatment; nevertheless, further study is needed to address unanswered scientific problems.

References

  1. Cell Commun Signal. 2023 Feb 9;21(1):33 [PMID: 36759799]
  2. Chronobiol Int. 2023 Apr;40(4):483-514 [PMID: 37013806]
  3. Imeta. 2022 Aug 15;1(4):e47 [PMID: 38867910]
  4. Phenomics. 2022 Jun 16;2(5):336-348 [PMID: 36939762]
  5. Mol Biol Rep. 2023 Jul;50(7):6159-6170 [PMID: 37231216]
  6. J Clin Monit Comput. 2024 Feb;38(1):147-156 [PMID: 37864755]
  7. Biochem Biophys Res Commun. 2023 Aug 20;669:120-127 [PMID: 37269594]
  8. J Neurooncol. 2024 Feb;166(3):419-430 [PMID: 38277015]
  9. Oncotarget. 2015 Apr 30;6(12):9951-8 [PMID: 25760074]
  10. Neurosci Bull. 2021 Apr;37(4):497-510 [PMID: 33528793]
  11. Aging (Albany NY). 2019 Dec 23;11(24):11814-11828 [PMID: 31881010]
  12. Front Genet. 2023 Mar 10;14:1096491 [PMID: 36968596]
  13. Brain Behav Immun. 2024 Jan;115:588-599 [PMID: 37984623]
  14. Esophagus. 2023 Oct;20(4):722-731 [PMID: 37093536]
  15. Mol Cancer Res. 2022 Jun 3;20(6):972-982 [PMID: 35190830]
  16. Nat Immunol. 2022 Feb;23(2):229-236 [PMID: 34949832]
  17. Neoplasia. 2023 Nov;45:100943 [PMID: 37852131]
  18. Cancer Discov. 2019 Nov;9(11):1556-1573 [PMID: 31455674]
  19. Trends Cell Biol. 2021 Nov;31(11):940-950 [PMID: 34272133]
  20. Nat Commun. 2020 Jun 24;11(1):3193 [PMID: 32581213]
  21. Nat Commun. 2021 Jun 28;12(1):4006 [PMID: 34183658]
  22. Cancer Drug Resist. 2023 Jun 20;6(2):390-415 [PMID: 37457134]
  23. Cancer Nurs. 2024 Mar-Apr 01;47(2):112-120 [PMID: 36728167]
  24. J Biol Chem. 2019 Jan 11;294(2):547-558 [PMID: 30429219]
  25. Lancet Oncol. 2022 Mar;23(3):e129-e143 [PMID: 35240088]
  26. Integr Biol (Camb). 2022 Jun 8;14(3):62-75 [PMID: 35652485]
  27. Cancers (Basel). 2020 Jun 29;12(7): [PMID: 32610705]
  28. Cell Death Discov. 2023 Jul 31;9(1):278 [PMID: 37524704]
  29. Front Cell Dev Biol. 2020 Oct 02;8:587697 [PMID: 33123539]
  30. Cureus. 2023 Mar 22;15(3):e36522 [PMID: 37090313]
  31. Clin Genitourin Cancer. 2023 Jun;21(3):e145-e152 [PMID: 36503724]
  32. Sci Adv. 2020 Oct 14;6(42): [PMID: 33055171]
  33. Int J Surg. 2022 Dec;108:106978 [PMID: 36347440]
  34. Cell Mol Gastroenterol Hepatol. 2020;9(2):219-237 [PMID: 31689559]
  35. Front Oncol. 2023 Mar 21;13:1101055 [PMID: 37025597]
  36. Oncotarget. 2016 Dec 27;7(52):85832-85847 [PMID: 27494874]
  37. CA Cancer J Clin. 2022 Jan;72(1):7-33 [PMID: 35020204]
  38. Cancer Immunol Res. 2022 Jun 3;10(6):770-784 [PMID: 35413115]
  39. J Immunol Res. 2021 May 24;2021:9995869 [PMID: 34124276]
  40. Cancer Discov. 2020 Mar;10(3):371-381 [PMID: 31919052]
  41. Nat Rev Mol Cell Biol. 2020 Feb;21(2):67-84 [PMID: 31768006]
  42. Front Genet. 2022 Aug 11;13:866696 [PMID: 36035192]
  43. Lancet Oncol. 2021 Dec;22(12):1777-1786 [PMID: 34780711]
  44. Cancer Med. 2020 Jun;9(12):4148-4159 [PMID: 32319740]
  45. Cancer Res. 2022 Apr 15;82(8):1503-1517 [PMID: 35255118]
  46. Nutrients. 2024 Jan 14;16(2): [PMID: 38257148]
  47. Cell Mol Gastroenterol Hepatol. 2021;12(1):251-276 [PMID: 33652118]
  48. Cell Death Dis. 2020 Apr 27;11(4):289 [PMID: 32341349]
  49. Environ Toxicol. 2024 Feb;39(2):487-508 [PMID: 37278231]
  50. Cell Rep. 2022 Oct 18;41(3):111514 [PMID: 36261012]
  51. Mech Ageing Dev. 2020 Sep;190:111317 [PMID: 32745473]
  52. Asian J Androl. 2023 Mar-Apr;25(2):223-229 [PMID: 36124532]
  53. Adv Biol (Weinh). 2022 Sep;6(9):e2200031 [PMID: 35652494]
  54. Sci Rep. 2017 Aug 30;7(1):9995 [PMID: 28855649]
  55. Front Cell Dev Biol. 2021 Mar 18;9:656981 [PMID: 33816508]
  56. Oncol Res. 2023 Mar 1;31(1):35-61 [PMID: 37303739]
  57. Cancer Res. 2018 Jul 1;78(13):3698-3708 [PMID: 29735553]
  58. Cardiovasc Res. 2023 Aug 19;119(10):1952-1968 [PMID: 37052172]
  59. Clin Pharmacol Ther. 2024 Jun;115(6):1282-1292 [PMID: 38264789]
  60. Int J Mol Sci. 2022 Nov 16;23(22): [PMID: 36430659]
  61. J Immunol. 2023 Jan 1;210(1):12-18 [PMID: 36542828]
  62. Cell Rep. 2023 Feb 28;42(2):112127 [PMID: 36795563]
  63. Front Oncol. 2022 Nov 15;12:1021453 [PMID: 36457490]
  64. Mol Biol Rep. 2022 Jan;49(1):373-384 [PMID: 34727291]
  65. Sci Rep. 2023 Sep 8;13(1):14803 [PMID: 37684377]
  66. Research (Wash D C). 2023 Dec 11;6:0287 [PMID: 38090608]
  67. Eur J Med Res. 2023 Feb 2;28(1):55 [PMID: 36732869]
  68. Expert Opin Drug Discov. 2023 Jul-Dec;18(8):893-901 [PMID: 37300813]
  69. Cancers (Basel). 2019 Jul 15;11(7): [PMID: 31311174]
  70. Drug Deliv Transl Res. 2024 Jul;14(7):1756-1775 [PMID: 38416386]
  71. Oncoimmunology. 2016 Nov 4;5(12):e1254854 [PMID: 28123897]
  72. Bioact Mater. 2023 Aug 09;31:63-86 [PMID: 37601277]
  73. J Pineal Res. 2021 Apr;70(3):e12726 [PMID: 33638890]
  74. Int J Surg. 2023 Sep 01;109(9):2631-2640 [PMID: 37788019]
  75. Chronobiol Int. 2023 Apr;40(4):417-437 [PMID: 36912021]
  76. Cancer Discov. 2022 Sep 2;12(9):2074-2097 [PMID: 35754340]
  77. Cell. 2002 Oct 4;111(1):41-50 [PMID: 12372299]
  78. Chin J Cancer Res. 2022 Apr 30;34(2):115-116 [PMID: 35685996]
  79. J Biol Rhythms. 2022 Feb;37(1):3-28 [PMID: 34969316]
  80. Mil Med Res. 2022 Sep 26;9(1):52 [PMID: 36154923]
  81. Oncol Res. 2023 Nov 15;32(1):175-185 [PMID: 38188676]
  82. Phytomedicine. 2024 May;127:155503 [PMID: 38490077]
  83. Cell Mol Gastroenterol Hepatol. 2021;12(5):1847-1872.e0 [PMID: 34534703]
  84. Aging Dis. 2023 Nov 26;15(6):2369-2380 [PMID: 38029391]
  85. Phenomics. 2023 May 23;3(4):360-374 [PMID: 37589027]
  86. Research (Wash D C). 2023 May 05;6:0139 [PMID: 37223461]
  87. Cancer Drug Resist. 2023 Oct 19;6(4):729-747 [PMID: 38239395]
  88. Imeta. 2022 Aug 15;1(4):e46 [PMID: 38867906]
  89. J Hematol Oncol. 2022 Apr 29;15(1):47 [PMID: 35488243]
  90. Pharmacol Ther. 2019 Oct;202:72-90 [PMID: 31173839]
  91. Trends Pharmacol Sci. 2018 Sep;39(9):812-827 [PMID: 30060890]
  92. Chin J Cancer Res. 2022 Oct 30;34(5):460-482 [PMID: 36398127]
  93. Biomed Pharmacother. 2023 Nov;167:115622 [PMID: 37783155]
  94. iScience. 2020 Feb 21;23(2):100839 [PMID: 32058954]
  95. J Cell Mol Med. 2020 Dec;24(24):14583-14595 [PMID: 33185980]
  96. J Ethnopharmacol. 2024 Jan 30;319(Pt 1):117067 [PMID: 37619857]
  97. Cancer Nurs. 2023 Nov 27;: [PMID: 38011048]
  98. Adv Sci (Weinh). 2023 Aug;10(24):e2301505 [PMID: 37330661]
  99. Aging Dis. 2022 Feb 1;13(1):8-23 [PMID: 35111358]
  100. Elife. 2020 May 12;9: [PMID: 32396064]
  101. J Circadian Rhythms. 2021 Feb 18;19:2 [PMID: 33633796]
  102. Support Care Cancer. 2023 Nov 17;31(12):705 [PMID: 37975923]
  103. Nature. 2023 Feb;614(7946):136-143 [PMID: 36470303]
  104. Cancer Cell. 2020 Apr 13;37(4):599-617.e7 [PMID: 32243837]
  105. Nutrients. 2023 Jan 04;15(2): [PMID: 36678130]
  106. Mil Med Res. 2022 Apr 14;9(1):19 [PMID: 35418160]

MeSH Term

Humans
Tumor Microenvironment
Circadian Rhythm
Neoplasms
Neovascularization, Pathologic
Animals
Aging
Inflammation
Journal Article Review

Word Cloud

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