Expert Consensus on Prevention and Treatment of Aging-Related Gonadal Dysfunction.
Xi Wang, Li Ma, Sheng Jiang, Junping Wen, Zhaoli Yan, Long Tian, Shan Deng, Boxian Huang, Ilia Stambler, Calogero Caruso, Kyung-Jin Min, Huanxing Su, Kunlin Jin, Jiangfeng Mao, Xueyan Wu, Qin Han, Robert Chunhua Zhao
Author Information
Xi Wang: Peking Union Medical College Hospital, Beijing, China.
Li Ma: Growth and Development and Gonadal Diseases Committee of Chines Aging Well Association, China.
Sheng Jiang: Growth and Development and Gonadal Diseases Committee of Chines Aging Well Association, China.
Junping Wen: Growth and Development and Gonadal Diseases Committee of Chines Aging Well Association, China.
Zhaoli Yan: Growth and Development and Gonadal Diseases Committee of Chines Aging Well Association, China.
Long Tian: Growth and Development and Gonadal Diseases Committee of Chines Aging Well Association, China.
Shan Deng: Peking Union Medical College Hospital, Beijing, China.
Boxian Huang: The affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215000, China.
Ilia Stambler: International Society on Aging and Disease, Bryan, TX, USA.
Calogero Caruso: International Society on Aging and Disease, Bryan, TX, USA.
Kyung-Jin Min: International Society on Aging and Disease, Bryan, TX, USA.
Huanxing Su: International Society on Aging and Disease, Bryan, TX, USA.
Kunlin Jin: International Society on Aging and Disease, Bryan, TX, USA.
Jiangfeng Mao: Peking Union Medical College Hospital, Beijing, China.
Xueyan Wu: Peking Union Medical College Hospital, Beijing, China.
Qin Han: Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China.
Robert Chunhua Zhao: International Society on Aging and Disease, Bryan, TX, USA.
Aging-related hypogonadism involves complex mechanisms in humans, predominantly relating to the decline of multiple hormones and senile gonads. Late-onset hypogonadism (LOH) and erectile dysfunction (ED) are the main manifestations in men, while premature ovarian insufficiency (POI) and menopause are the main forms in women. Anti-aging measures include lifestyle modification and resistance training, hormonal supplementation, stem cell therapy, metformin, and rapamycin. In this expert consensus, the mechanisms, efficacy, and side effects of stem cell therapy on aging gonadal function are reviewed. Furthermore, various methods of stem cell therapy, administered intravenously, intracavernously, and intra-ovarially, are exemplified in detail. More clinical trials on aging-related gonadal dysfunction are required to solidify the foundation of this topic.
