A new light on PLC��!

Sithurandi Ubeysinghe, Waruna Thotamune, Ajith Karunarathne
Author Information
  1. Sithurandi Ubeysinghe: Department of Chemistry, Saint Louis University, Saint Louis, MO 63103, USA.
  2. Waruna Thotamune: Department of Chemistry, Saint Louis University, Saint Louis, MO 63103, USA.
  3. Ajith Karunarathne: Department of Chemistry, Saint Louis University, Saint Louis, MO 63103, USA. Electronic address: wkarunarathne@slu.edu.

Abstract

In this issue of Cell Chemical Biology, Kim et al. present a novel optogenetic tool, opto-PLC��, to control PLC�� signaling optically. In addition to eliciting PIP2 hydrolysis and downstream signaling in cells, opto-PLC�� also enabled probing the impact of PLC�� signaling on amygdala synaptic plasticity and fear learning in mice.

MeSH Term

Phospholipase C beta
Animals
Mice
Optogenetics
Signal Transduction
Humans
Neuronal Plasticity
Amygdala

Chemicals

Phospholipase C beta

Word Cloud

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