Martin Purpura, Ralf J��ger, Ashok Godavarthi, Dhananjaya Bhaskarachar, Grant M Tinsley
PURPOSE: L-Ascorbic acid (vitamin C) is an essential water-soluble vitamin that plays an important role in various physiological functions, including immune health. The stability of vitamin C in the gastrointestinal tract its bioavailability is limited. This study aimed to investigate if a liposomal form of vitamin C can increase absorption compared to standard vitamin C.
METHODS: In a randomized, double-blind, placebo-controlled, crossover fashion, 19 males and 8 females (n���=���27; 36.0��������5.1 years, 165.0��������6.9 cm, 70.6��������7.1 kg) ingested a single-dose of placebo (PLA), 500 mg vitamin C (VIT C), and 500 mg liposomal vitamin C (LV-VIT C, LipoVantage, Specnova, LLC, Tyson Corner, VA, USA). Venous blood samples were collected 0, 0.5-, 1-, 1.5-, 2-, 3-, 4-, 6-, 8-, 12-, and 24-hours after ingestion and were analyzed for plasma and leukocyte vitamin C concentration.
RESULTS: VIT C.and LV-VIT C.demonstrated significantly greater Cmax and AUC in plasma and in leukocytes compared to placebo (p���<���0.001). Additionally, LV-VIT C.had significantly higher Cmax (plasma���+���27%, leukocytes���+���20%, p���<���0.001) and AUC (plasma���+���21%, leukocytes���+���8%, p���<���0.001) values as compared to VIT C.
CONCLUSION: Liposomal formulation of vitamin C increases absorption into plasma and leukocytes.
TRIAL REGISTRATION: Clinical Trials Registry - India (CTRI/2023/04/051789).