Pregnancy in women with mitochondrial disease-A literature review and suggested guidance for preconception and pregnancy care.
Lisa Hui, Pema Hayman, Ali Buckland, Michael C Fahey, David A Mackey, Andrew J Mallett, Daniel R Schweitzer, Clare P Stuart, Wai Yan Yau, John Christodoulou
Author Information
Lisa Hui: Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Melbourne, Victoria, Australia. ORCID
Pema Hayman: College of Medicine and Dentistry, James Cook University, Cairns, Queensland, Australia. ORCID
Ali Buckland: Department of Neurology, Perron Institute for Neurological and Translational Science, Perth, Western Australia, Australia.
Michael C Fahey: Department of Paediatrics, Monash University, Melbourne, Victoria, Australia. ORCID
David A Mackey: Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia, Australia. ORCID
Andrew J Mallett: College of Medicine and Dentistry, James Cook University, Cairns, Queensland, Australia. ORCID
Daniel R Schweitzer: Department of Neurology, Mater Hospital, Brisbane, Queensland, Australia.
Clare P Stuart: Mito Foundation, Sydney, New South Wales, Australia. ORCID
Wai Yan Yau: Department of Neurology, Perron Institute for Neurological and Translational Science, Perth, Western Australia, Australia. ORCID
John Christodoulou: Brain and Mitochondrial Research Group, Murdoch Children's Research Institute, Melbourne, Victoria, Australia. ORCID
Mitochondrial donation to reduce the risk of primary mitochondrial disease transmission from mother to child is now permitted under Australian law as part of a clinical trial. The energy demands of pregnancy have the potential to worsen mitochondrial disease symptoms and severity in affected women. We conducted a systematic literature review on mitochondrial disease in pregnancy; five cohort studies and 19 case reports were included. For many women with mitochondrial disease, pregnancy does not have a negative effect on health status. However, serious adverse outcomes may occur. We provide suggested guidelines for preconception counselling and antenatal care.
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Intrapartum care for women with existing medical conditions or obstetric complications and their babies. 2019 Updated 25 April 2019.
