High-loading ficin@AuNPs on polymer-UiO-66 surface with enhanced peroxidase-mimetic catalytic activity for colourimetric detection of dopamine.

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Yutong Liu, Lin Tian, Zhenwen Zhao, Wei Liu, Li Qi

Author Information

Yutong Liu: Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Beijing National Laboratory for Molecular Sciences, Chinese Academy of Sciences, Beijing, 100190, P. R. of China.
Lin Tian: Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Beijing National Laboratory for Molecular Sciences, Chinese Academy of Sciences, Beijing, 100190, P. R. of China.
Zhenwen Zhao: Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Beijing National Laboratory for Molecular Sciences, Chinese Academy of Sciences, Beijing, 100190, P. R. of China.
Wei Liu: School of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, P. R. China. liuwei@xxmu.edu.cn.
Li Qi: Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Beijing National Laboratory for Molecular Sciences, Chinese Academy of Sciences, Beijing, 100190, P. R. of China. qili@iccas.ac.cn.

PMID: 39313731 DOI: 10.1007/s00604-024-06689-3

Recently, MOFs@AuNPs composites-based catalysts via anchoring of AuNPs onto metal-organic-frameworks (MOFs) have attracted great attention. However, the influence of the AuNPs loading amounts on the catalytic activity of MOFs@AuNPs composites remains largely unexplored. Here, ficin (Fic) protected AuNPs (Fic@AuNPs) anchored onto the surface of UiO-66-NH (UiO) modified with poly(2-vinyl-4,4-dimethyl-2-oxazolidine) (PV) were designed and constructed. The UiOPVFic@AuNPs composites with longer PV chains leading to high-loading Fic@AuNPs exhibited intense peroxidase (POD)-mimetic activity in 3,3'5,5'-tetramethylbenzidine (TMB) oxidation. Further, following the colour-fading, dopamine (DA) was sensitively and selectively monitored in the composites-TMB-HO system. The portable smartphone sensing platform-based colourimetric method had good linearity ranging from 3.34 to 36.7 μM (R = 0.995), with a limit of detection of 0.3 μM. This protocol explores high-loading AuNPs on polymer-MOFs composites, providing deep insights into understanding catalytic activity improvements of polymer-MOFs@AuNPs catalysts and revealing their application potential in real biological samples analysis.

Fic@AuNPs Metal organic framework Peroxidase-mimetic activity Poly (2-vinyl-4,4-dimethyl-2-oxazolidine) Surface loading

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22274159/National Natural Science Foundation of China

Humans

Benzidines

Biomimetic Materials

Catalysis

Colorimetry

Dopamine

Ficain

Gold

Hydrogen Peroxide

Limit of Detection

Metal Nanoparticles

Metal-Organic Frameworks

Oxidation-Reduction

Peroxidase

Polyvinyls

Smartphone

3,3',5,5'-tetramethylbenzidine