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Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
Oct, 2024;30 (10): e70102.

Functional Properties and Components of Koenigia alpina Extract.

Kwan-Woo Lee, Su-Hyun Mun, Yeon-A Kim, Hyo-Rim Kim, Qinglong Jin, Min-Ki Lee, Soo Nam Park
Author Information
  1. Kwan-Woo Lee: ISTY ON NATURE, Suwon-si, Gyeonggi-do, Republic of Korea.
  2. Su-Hyun Mun: NBBIO Company, Suwon-si, Gyeonggi-do, Republic of Korea.
  3. Yeon-A Kim: NBBIO Company, Suwon-si, Gyeonggi-do, Republic of Korea.
  4. Hyo-Rim Kim: NBBIO Company, Suwon-si, Gyeonggi-do, Republic of Korea.
  5. Qinglong Jin: NBBIO Company, Suwon-si, Gyeonggi-do, Republic of Korea. ORCID
  6. Min-Ki Lee: NBBIO Company, Suwon-si, Gyeonggi-do, Republic of Korea.
  7. Soo Nam Park: Department of Biohealth Engineering, College of Science and Convergence Technology, Seoul Women's University, Nowon-gu, Seoul, Republic of Korea.
PMID: 39387830 DOI: 10.1111/srt.70102

Abstract

BACKGROUND: Koenigia alpina (All.) T.M.Schust. & Reveal (alpine knotweed) is a perennial herb belonging to the Polygonaceae family. Several studies have examined Polygonaceae species' potential applications as cosmeceutical materials; however, the potential of K. alpina as a cosmeceutical has not yet been studied.
MATERIALS AND METHODS: Hydrogen peroxide (HO) and lipopolysaccharide were used to induce an inflammatory response in RAW 264.7 cells. 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radicals and HO were used to evaluate the free-radical scavenging activity of K. alpina extract and its protective effect against reactive oxygen species (ROS)-induced cell damage. The whitening, antiaging, and cell proliferation/migration effects of the extracts were evaluated via tyrosinase inhibition, collagenase/elastase inhibition, and wound healing assays, respectively. The anti-inflammatory effect was confirmed by evaluating nitric oxide (NO) production in RAW 264.7 cells. High-performance liquid chromatography (HPLC), UV, and MS/MS were used to determine the main components of the extract and fractions.
RESULTS: The ethyl acetate (EA) fraction and its aglycone fraction showed very high free-radical scavenging activities (47.5 and 47.1 µg/mL, respectively). The extract/fractions also showed significant tyrosinase inhibition (IC = 0.38 mg/mL in EA fraction), collagenase inhibition (IC = 0.21 mg/mL in EA fraction), and elastase inhibition (IC = 0.57 mg/mL in aglycone fraction). NO production in lipopolysaccharide-induced RAW 264.7 cells was inhibited by the extract/fractions. The extract also promoted the closure of scratch wounds in HaCaT cells. The K. alpina extract/fractions contained cardamonin, quercetin, and quercitrin.
CONCLUSION: K. alpina extracts/fractions showed antioxidant, antiaging, whitening, and anti-inflammatory activities, suggesting they may have potential as antiaging cosmeceuticals.

Keywords

Koeniga alpina antiaging bioactivity antioxidant anti‐inflammatory botanical whitening

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MeSH Term

Plant Extracts
Mice
Animals
RAW 264.7 Cells
Humans
Anti-Inflammatory Agents
Polygonaceae
Nitric Oxide
Cell Proliferation
Antioxidants
Reactive Oxygen Species
Hydrogen Peroxide
Free Radical Scavengers
Wound Healing
Skin Aging
Cell Movement
Lipopolysaccharides
Biphenyl Compounds
Skin Lightening Preparations
Picrates
Monophenol Monooxygenase
HaCaT Cells

Chemicals

Plant Extracts
Anti-Inflammatory Agents
Nitric Oxide
Antioxidants
Reactive Oxygen Species
Hydrogen Peroxide
Free Radical Scavengers
Lipopolysaccharides
Biphenyl Compounds
Skin Lightening Preparations
1,1-diphenyl-2-picrylhydrazyl
Picrates
Monophenol Monooxygenase
Journal Article

Word Cloud

Created with Highcharts 10.0.0alpinainhibitionfractionKcellsantiagingpotentialusedRAW2647extractwhiteningEAshowedextract/fractionsIC=0KoenigiaPolygonaceaecosmeceuticalHOfree-radicalscavengingeffectcelltyrosinaserespectivelyanti-inflammatoryNOproductionaglyconeactivities47alsoantioxidantBACKGROUND:AllTMSchust&RevealalpineknotweedperennialherbbelongingfamilySeveralstudiesexaminedspecies'applicationsmaterialshoweveryetstudiedMATERIALSANDMETHODS:Hydrogenperoxidelipopolysaccharideinduceinflammatoryresponse22-Diphenyl-1-picrylhydrazylDPPHradicalsevaluateactivityprotectivereactiveoxygenspeciesROS-induceddamageproliferation/migrationeffectsextractsevaluatedviacollagenase/elastasewoundhealingassaysconfirmedevaluatingnitricoxideHigh-performanceliquidchromatographyHPLCUVMS/MSdeterminemaincomponentsfractionsRESULTS:ethylacetatehigh51 µg/mLsignificant38 mg/mLcollagenase21 mg/mLelastase57 mg/mLlipopolysaccharide-inducedinhibitedpromotedclosurescratchwoundsHaCaTcontainedcardamoninquercetinquercitrinCONCLUSION:extracts/fractionssuggestingmaycosmeceuticalsFunctionalPropertiesComponentsExtractKoenigabioactivityanti‐inflammatorybotanical

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