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Wiley interdisciplinary reviews. Cognitive science
2025 Jan-Feb;16 (1): e1692.

Advances in neuroscience research and big data's analysis on anxiety disorder.

Qianmei Yu, Meihua Ruan, Yongjun Chen, Chun Wang
Author Information
  1. Qianmei Yu: Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, China.
  2. Meihua Ruan: Shanghai Institute of Nutrition and Health, Shanghai Information Center for Life Sciences, Chinese Academy of Science, Shanghai, China.
  3. Yongjun Chen: Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, China.
  4. Chun Wang: Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, China. ORCID
PMID: 39390772 DOI: 10.1002/wcs.1692

Abstract

anxiety disorder is a complex disease with the influence of environmental and genetic factors and multimolecular participation, and it is also one of the most common mental disorders. The causes of disorders are not clear but may include a variety of social, psychological, and biological factors. Therefore, neither genetics, neurobiology, nor neuroimaging can independently explain the pathological mechanism. By searching the Web of Science databases, Derwent Innovation Patent database, ClinicalTrials.gov database, and Cortellis database, we analyze the current situation of papers, patents, clinical trials, and drugs of anxiety disorder. Second, the existing literature was reviewed to summarize the neurophysiological mechanism, brain imaging, gene, anti-anxiety drugs, and other aspects of anxiety disorders. This article reviews the research status of anxiety disorders. The heterogeneity of the disease, lack of treatment effectiveness, and gaps in translational medicine still present barriers to further advancement. Thus, in-depth explorations of the underlying biological mechanisms of anxiety disorders, the detection and intervention of biological targets, and further developments based on existing intervention strategies will drive future research on anxiety disorders. This article is categorized under: Neuroscience > Clinical.

Keywords

anxiety disorders neuroscience pathogenesis progress treatment

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Grants

  1. 81871344/National Natural Science Foundation of China
  2. 81971289/National Natural Science Foundation of China
  3. BE2019609/The Jiangsu Provincial Key Research and Development Program
  4. BK20191369/The Natural Science Foundation of Jiangsu Province

MeSH Term

Humans
Anti-Anxiety Agents
Anxiety Disorders
Big Data
Brain
Neuroimaging
Neurosciences

Chemicals

Anti-Anxiety Agents
Journal Article Review

Word Cloud

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